Abstract
Peripheral administration of scopolamine tended to reduce the frequencies of three exploratory acts in mouse strain C57BL/6 and to increase them in strain DBA/2, whereas methylscopolamine was ineffective. Physostigmine diminished these exploratory scores in both genotypes, whereas neostigmine had no such effects. These observations support the hypothesis of a genetically controlled cholinergic mechanism which is located in the brain and which facilitates exploratory behaviour in mice.
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van Abeelen, J.H.F., Smits, A.J.M. & Raaijmakers, W.G.M. Central location of a genotype-dependent cholinergic mechanism controlling exploratory behaviour in mice. Psychopharmacologia 19, 324–328 (1971). https://doi.org/10.1007/BF00404376
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DOI: https://doi.org/10.1007/BF00404376