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Blood levels, urinary excretion and potential toxicity of N, N′-trimethylenebis (pyridinium 4-aldoxime) dichloride (TMB-4) in healthy man following intramuscular injection of the oxime

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Summary

A dose of 250 mg (2.5–3.5 mg/kg body weight) of TMB-4 was given by i.m. injection to 12 healthy male subjects. The concentration of oxime in blood reached 2 μ/ml blood in 5 min and was sustained above this level for the subsequent 2.5 h. Within the first 4 h after its administration, 46% of the oxime was excreted in the urine. Observations on subjective manifestations following administration of the oxime and its effect on the cardiovascular and respiratory system indicate that TMB-4, in the dose range studied, is as well tolerated as other oximes in doses which would be expected to have a comparable antidotal action in dialkylphosphate poisoning. The results are discussed in relation to published information on other oximes.

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  1. Institute of Toxicology, Military Medical Academy, Pasterova 2, Belgrade, Yugoslavia

    V. B. Vojvodić

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Vojvodić, V.B. Blood levels, urinary excretion and potential toxicity of N, N′-trimethylenebis (pyridinium 4-aldoxime) dichloride (TMB-4) in healthy man following intramuscular injection of the oxime. Pharmacol. Clin. 2, 216–220 (1970). https://doi.org/10.1007/BF00404303

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