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Compound 84/F 1983 compared with D-amphetamine and placebo in regard to effects on human performance

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Summary

  1. 1.

    This study establishes that ingestion of either 30 mg or 60 mg of 84/F 1983 by moderately fatigued normal humans will significantly arrest the decrement in performance over time on a simple mental task shown by placebo subjects.

  2. 2.

    While the mean scores of subjects ingesting either 30 mg or 60 mg of 84/F 1983 were generally higher than the mean scores of subjects ingesting 10 mg of d-amphetamine, no statistically significant difference was found between these 3 drug groups with the exception that the 60 mg 84/F 1983 group showed a significantly higher mean performance than the 30 mg 84/F 1983 group by the end of 1 hour postdrug.

  3. 3.

    Under the conditions of this study, 84/F 1983 appears to be a highly effective psychostimulant which resembles d-amphetamine in its enhancing effect on human performance.

  4. 4.

    The replication of this method for discriminating between the effects of stimulants and a placebo on human performance of a simple mental task shows the method to be highly reliable.

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References

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  • Wander Research Institute, Berne (Switzerland): Unpublished.

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Authors and Affiliations

  1. Psychopharmacology Research Program, Department of Pharmacology, University of Washington, Seattle, Washington

    Audrey R. Holliday, Richard B. Morris & Robert P. Sharpley

Authors
  1. Audrey R. Holliday
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  2. Richard B. Morris
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  3. Robert P. Sharpley
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Additional information

Supported by United States Public Health Service grant MY-3311 and by the Research Institute of Dr. A. Wander S. A., Berne, Switzerland.

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Holliday, A.R., Morris, R.B. & Sharpley, R.P. Compound 84/F 1983 compared with D-amphetamine and placebo in regard to effects on human performance. Psychopharmacologia 6, 192–200 (1964). https://doi.org/10.1007/BF00404009

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  • DOI: https://doi.org/10.1007/BF00404009

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