Summary
The effects of nicotine on bar-pressing behaviour in the rat are blocked by mecamylamine. The depressant phase of the effect is blocked by atropine, supporting the conclusion that this depression is mediated by released acetylcholine. The quaternary compounds chlorisondamine and atropine methylnitrate also antagonise the behavioural effects of nicotine but the doses required for this are far in excess of those which are effective peripherally, suggesting that the sites of interaction are central.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brodie, B. B., and A. M. Hogben: Some physico-chemical factors in drug action. J. Pharm. Pharmacol. 9, 345–380 (1957).
Bülbring, E., and G. S. Dawes: A method for the assay of atropine substitutes on the salivary secretion. J. Pharmacol. exp. Ther. 84, 177–183 (1945).
Ing, H. R., G. S. Dawes, and I. Wajda: Synthetic substitues for atropine. J. Pharmacol. exp. Ther. 85, 85–102 (1945).
Lewis, J. J.: An introduction to pharmacology. Edinburgh: E. & S. Livingstone Ltd. 1965.
Morrison, C. F.: The modification by physostigmine of some effects of nicotine on bar-pressing behaviour of rats. Brit. J. Pharmacol. 32, 28–33 (1968).
Paul-David, J., J.-L. Riehl, and K. R. Unna: Quantification of effects of depressant drugs on EEG activation response. J. Pharmacol. exp. Ther. 129, 69–74 (1960).
Vaillant, G. E.: Antagonism between physostigmine and atropine on the behaviour of the pigeon. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 406–416 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morrison, C.F., Goodyear, J.M. & Sellers, C.M. Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine. Psychopharmacologia 15, 341–350 (1969). https://doi.org/10.1007/BF00403709
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00403709