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Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents

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Summary

A method for semiquantitative evaluation of potential reserpine antagonists in mice has been described. Desmethylimipramine is the most potent reserpine antagonist among several imipramine derivatives tested, However, promazine and antihistaminic agents also antagonize the effects of reserpine, whereas atropine and serotonin antagonists fail to do so. It is speculated that the antihistaminergic properties of these compounds are, at least partly, involved in the mechanism of reserpine antagonism.

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Author notes

  1. Laszlo Gyermek

    Present address: Syntex Laboratories, Palo Alto, California

Authors and Affiliations

  1. The Department of Pharmacology Geigy Research, Division of Geigy Chemical Corp., Ardsley, New York, USA

    Ernest B. Sigg, Laszlo Gyermek & Ronald T. Hill

Authors
  1. Ernest B. Sigg
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  2. Laszlo Gyermek
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  3. Ronald T. Hill
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Sigg, E.B., Gyermek, L. & Hill, R.T. Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents. Psychopharmacologia 7, 144–149 (1965). https://doi.org/10.1007/BF00403637

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  • DOI: https://doi.org/10.1007/BF00403637

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