Summary
Central cholinergic blockade produced by the administration of scopolamine hydrobromide significantly increased the toxicity of amphetamine in aggregated mice. Stimulation of the central cholinergic system by Tremorine, on the other hand, afforded protection against the lethal effect of amphetamine in aggregated mice, reduced spontaneous motor activity, and antagonized the effect of amphetamine on motor activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bliss, C. I.: The determination of the dosage-mortality curve from small numbers. Quart. J. Pharm. 11, 192–216 (1938).
Brodie, B. B., S. Spector, and P. A. Shore: Interaction of drugs with norepinephrine in the brain. Pharmacol. Rev. 11, 548–564 (1959).
Carlton, P. L.: Augmentation of the behavioral effects of amphetamine by scopolamine. Psychopharmacologia (Berl.) 2, 377–380 (1961).
—, and P. Didamo: Augmentation of the behavioral effects of amphetamine by atropine. J. Pharmacol. exp. Ther. 132, 91–96 (1961).
Chalmers, R. K., and C. K. Erickson: Central cholinergic blockade of the conditioned avoidance response in rats. Psychopharmacologia (Berl.) 5, 31–41 (1964).
Chance, M. R. A.: Aggregation as a factor influencing the toxicity of sympatho mimetic amines in mice. J. Pharmacol. exp. Ther. 87, 214–219 (1946).
Chen, G.: The anti-tremorine effect of some drugs as determined by Haffner's method of testing analgesia in mice. J. Pharmacol. exp. Ther. 124, 73–76 (1958).
Everett, G. M., L. E. Blockus, and I. M. Sheppard: Tremor induced by tremorine and its antagonism by anti-parkinson drugs. Science 124, 79 (1956).
Fisher, R. A.: The design of experiments, 11th edit. Edinburgh: Oliver and Boyd 1950.
Goodman, L. S., and A. Gilman: The pharmacological basis of therapeutics. 2nd edit. New York: Macmillan 1955.
Harris, L. S.: A pharmacologic demonstration of cholinergic mechanisms in the central nervous system. Biochem. Pharmacol. 8, 312 (1961a).
—: The effect of various anti-cholinergics on spontaneous activity of mice. Fed. Proc. 20, 395 (1961b).
Hess, W. R.: Diencephalon: Autonomic and extrapyramidal functions. Monogr. Biol. Med. 3. New York: Grune and Stratton 1954.
Kaelber, W. W., and R. E. Correll: Cortical and subcortical electrical effects of psychopharmacologic and tremor-producing compounds. Arch. Neurol. Psychiat. (Chic.) 80, 544–553 (1958).
Litchfield, S. T., jr., and F. Wilcoxon: A simplified method of evaluting dose-effect experiments. J. Pharmacol. exp. Ther. 96, 99–113 (1949).
Macht, D. I.: A pharmacodynamic analysis of the cerebral effects of atropin, homatropin, scopolamin and related drugs. J. Pharmacol. exp. Ther. 22, 35–48 (1924).
Meyers, B., K. H. Roberts, R. H. Riciputi, and E. F. Domino: Some effects of muscarinic cholinergic blocking drugs on behavior and the electrocorticogram. Psychopharmacologia (Berl.) 5, 289–300 (1964).
Pfeiffer, C. C., and E. H. Jenney: The inhibition of the conditioned response and the counteraction of schizophrenia by muscarinic stimulation of the brain. Ann. N. Y. Acad. Sci. 66, 753–764 (1957).
Smith, C. B.: Enhancement by reserpine and methyl DOPA of the effects of d-amphetamine upon locomotor activity of mice. J. Pharmacol. exp. Ther. 142, 343–350 (1963).
Tripod, J.: Caractérisation générale des effects pharmacodynamiques de substances psycho tropiques. In: Psychotropic Drugs. Edited by Garattini, S. and V. Ghetti. Amsterdam: Elsevier 1957.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mennear, J.H. Interactions between central cholinergic agents and amphetamine in mice. Psychopharmacologia 7, 107–114 (1965). https://doi.org/10.1007/BF00403633
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00403633