Summary
A 23-year-old woman with metastatic Sertoli-Leydig cell tumor was treated with cisplatin, vinblastine, and bleomycin. Hemolytic uremic syndrome appeared, while no evidence of residual tumor was found. Infusion of fresh frozen plasma together with aspirin and dipyridamole resulted in recovery of microangiopathic hemolytic anemia and thrombocytopenia. Renal insufficiency, however, persisted.
Similar content being viewed by others
References
Adamson, IYR, Bowden DH (1974) The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Am J Pathol 77:185–190
Antman KH, Skarin AT, Mayer RJ, Hargreaves HK, Canellos GP (1979) Microangiopathic hemolytic anemia and cancer: a review. Medicine 58:377–384
Brain MC, Azzopardi JG, Baker LRI, Pineo GF, Roberts PD, Dacie JV (1970) Microangiopathic haemolytic anaemia and mucinforming adenocarcinoma. Br J Haematol 18:183–192
bukowski RM (1982) Thrombotic thrombocytopenic purpura: a review. In: Spaet TH (ed) Progress in hemostasis and thrombosis, Vol. 6. Grune and Stratton, New York, pp 287–337
Chernicoff DP, Bukowski RM, Young JR (1978) Raynaud's phenomenon after bleomycin treatment. Cancer Treat Rep 62:570–571
Clarkson AR, Lawrence JR, Meadows R, Seymour AE (1970) The haemolytic uraemic syndrome in adults. Q J Med 34:227–239
Cohen IS, Mosher MB, O'Keefe EJ, Klaus SN, Deconti RC (1973) Cutaneous toxicity of bleomycin therapy. Arch Dermatol 107:553–555
Defreyn G, Proesmans W, Machin SJ, Lemmens F, Vermylen J (1982) Abnormal prostacyclin metabolism in the hemolytic uremic syndrome: equivocal effect of prostacyclin infusions. Clin Nephrol 18:43–49
Edwards GS, Lane M, Smith FE (1979) Long-term treatment with cis-dichlorodiammineplatinum(II)-vinblastine-bleomycin: possible association with severe coronary artery disease. Cancer Treat Rep 63:551–552
Gulati SC, Sordillo P, Kempin S, Reich L, Magill GB, Scheiner E, Clarkson B (1980) Microangiopathic hemolytic anemia observed after treatment of epidermoid carcinoma with mitomycin-C and 5-fluorouracil. Cancer 45:2252–2257
Gutterman LA, Levin DM, George BS, Sharma HM (1983) The hemolytic-uremic syndrome: recovery after treatment with vincristine. Ann Int Med 98:612–613
Hamner RW, Verani R, Weinman EJ (1983) Mitomycin-associated renal failure. Case report and review. Arch Intern Med 143:803–807
Hanna WT, Krauss S, Regester RF, Murphy WM (1981) Renal disease after mitomycin-C therapy. Cancer 48:2583–2588
Harrell RM, Sibley R, Vogelzang NJ (1982) Renal vascular lesions after chemotherapy with vinblastine, bleomycin, and cisplatin. Am J Med 73:429–433
Jackson AM, Rose BD, Graff LG, Jacobs JB, Schwartz JH, Strauss GM, Yang JPS, Rudnick MR, Elfenbein IB, Narins RG (1984) Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. Ann Int Med 101:41–44
Jones BG, Newman CE, Fielding JW, Howell A, Brookes VS (1980) Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C. Lancet I:1275–1277
Kressel BK, Ryan KP, Duong AT, Berenberg J, Schein PS (1981) Microangiopathic hemolytic anemia, thrombocytopenia, and renal failure in patients treated for adenocarcinoma. Cancer 48:1738–1745
Lohrmann, HP, Adam W, Heymer B, Kubanek B (1973) Microangiopathic hemolytic anemia in metastatic carcinoma. Report of eight cases. Ann Intern Med 79:368–375
Lyman NW, Michaelson R, Viscuso RL, Winn R, Mulgaonkar S, Jacobs MG (1983) Mitomycin-induced hemolytic-uremic syndrome. Successful treatment with corticosteroids and intense plasma exchange. Arch Intern Med 143:1617–1618
O'Regan S, Chesney RW, Mongeau JG, Robitaille P (1980) Aspirin and dipyridamole therapy in the hemolytic-uremic syndrome. J Pediatr 97:473–476
Pavy MD, Wiley EL, Abeloff MD (1982) Hemolytic-uremic syndrome associated with mitomycin therapy. Cancer Treat Rep 66:457–461
Remuzzi G, Misiani R, Marchesi D, Livio M, Mecca G, De Gaetano G, Donati MB (1979) Treatment of the hemolytic uremic syndrome with plasma. Clin Nephrol 12:279–284
Rothberg H (1978) Raynaud's phenomenon after vinblastine-bleomycin chemotherapy. Cancer Treat Rep 62:569–570
Soble AR (1978) Chronic bleomycin-associated Raynaud's phenomenon. Cancer Treat Rep 62:570
Teutsch C, Lipton A, Harvey HA (1977) Raynaud's phenomenon as a side effect of chemotherapy with vinblastine and bleomycin for testicular carcinoma. Cancer Treat Rep 61:925–926
Thysell H, Oxelius VA, Norlin M (1982) Successful treatment of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura with fresh frozen plasma and plasma exchange. Acta Med Scand 212:285–288
Vogelzang NJ, Frenning DH, Kennedy BJ (1980) Coronary artery disease after treatment with bleomycin and vinblastine. Cancer Treat Rep 64:1159–1160
Vogelzang NJ, Bosl GJ, Johnson K, Kennedy BJ (1981) Raynaud's phenomenon: a common toxicity after combination chemotherapy for testicular cancer. Ann Int Med 95:288–292
Vogelzang NJ (1984) Vascular and other complications of chemotherapy for testicular cancer. World J Urol 2:32–37
Von Hof DD, Schilsky R, Reichert CM, Reddick RL, Rozencweig M, Young RC, Muggia FM (1979) Toxic effects of cis-dichlorodiammine platinum(II) in man. Cancer Treat Rep 63:1527–1531
Webster J, Rees AJ, Lewis PJ, Hensby CN (1980) Prostacyclin deficiency in haemolytic-uraemic syndrome. Br Med J 281:271
Yagoda A, Mukherji B, Young C, Etcubanas E, Lamonte C, Smith JR, Tan CTC, Krakof IH (1972) Bleomycin, an antitumor antibiotic. Ann Int Med 77:861–870
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van der Meer, J., de Vries, E.G.E., Vriesendorp, R. et al. Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin. J Cancer Res Clin Oncol 110, 119–122 (1985). https://doi.org/10.1007/BF00402723
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00402723