Summary
Ectoderm from early gastrula stages of amphibians was isolated and treated with phorbol 12-myristate 13-acetate. The ectoderm formed neural tissue and in a few cases also mesenchyme and melanophores. The control explants formed atypical epidermis. In explants treated with phorbol 12-myristate 13-acetate the mitotic rate was increased.
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Davids, M., Loppnow, B., Tiedemann, H. et al. Neural differentiation of amphibian gastrula ectoderm exposed to phorbol ester. Roux's Arch Dev Biol 196, 137–140 (1987). https://doi.org/10.1007/BF00402036
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DOI: https://doi.org/10.1007/BF00402036