Abstract
Twenty-six healthy young male subjects drank ethyl alcohol (diluted in orange juice) in doses ranging from 0.5–2.0 ml/kg (0.4–1.6 g/kg). Levels of performance on three measures correlated well with dose and blood alcohol levels and decline of effects paralleled the fall in blood levels. The greatest decrement in performance was on the test requiring hand-eye coordination; lesser decrements were produced on tests of cognitive ability.
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References
Aghajanian, G. K., Bing, O. H. L.: Persistence of lysergic acid diethylamide in the plasma of human subjects. Clin. Pharmacol. Ther. 5, 611–614 (1964).
Bliss, C. I.: The statistics of bioassay. New York: Academic Press 1952.
Crowell, E. B., Jr., Ketchum, J. S.: The treatment of scopolamine-induced delirium with physostigmine. Clin. Pharmacol. Ther. 8, 409–414 (1967).
Edwards, J. A., Evans, D.A.P.: Ethanolmetabolism in subjects possessing typical and atypical liver alcohol dehydrogenase. Clin. Pharmacol. Ther. 8, 824–829 (1967).
Ekman, G., Frankenhaeuser, M., Goldberg, L., Bjerver, K., Jarpe, G., Myrsten, A.: Effects of alcohol intake on subjective and objective variables over a five-hour period. Psychopharmacologia (Berl.) 4, 28–38 (1963).
— — —, Hagdahl, R., Myrsten, A.: Subjective and objective effects of alcohol as functions of dosage and time. Psychopharmacologia (Berl.) 6, 399–409 (1964).
Goldberg, L.: Behavioural and physiological effects of alcohol on man. Psychosom. Med. 28, 570–595 (1966).
—, Watts, C.: Serum enzyme changes as Evidence of liver reaction to oral alcohol. Gastroenterology 49, 256–261 (1965).
Goldstein, A., Aronow, L., Kalman, S. M.: Principles of drug action, pp. 285–286. New York: Harper and Row 1968.
Groff, W. A., Mounter, L. A., Sim, V. M.: A multichannel analytical system for continuous monitoring of blood cholinesterase. Teehn. Symp. 1, 498–502 (1966).
Hollister, L. E., Clyde, D. J.: Blood levels of pentobarbital sodium, meprobamate, and tybamate in relation to clinical effect. Clin. Pharmacol. Ther. 9, 204–208 (1968).
Idestrom, C., Cadenius, B.: Time relations of the effects of alcohol compared to placebo. Psychopharmacologia (Berl.) 13, 189–200 (1968).
Jacobsen, E.: The metabolism of ethyl alcohol. Pharmacol. Rev. 4, 107–135 (1952).
Leake, C. D., Silverman, M.: Alcoholic beverages in clinical medicine. Chicago: Yearbook Medical Publishers. Ind. 1966.
Lundquist, F., Wolthers, H.: The kinetics of alcohol elimination in man. Acta pharmacol. (Kbh.) 14, 265–289 (1958).
Mayfield, D., Allen, D.: Alcohol and affect: A psychopharmacological study. Amer. J. Psychiat. 123, 1346–1351 (1967).
Mendelson, J. H., Stein, S.: Serum cortisol levels in alcoholic and nonalcoholic subjects during experimentally induced ethanol intoxication. Psychosom. Med. 28, 616–626 (1966).
— —, McGuire, M. T.: Comparative psychophysiological studies of alcoholic and nonalcoholic subjects undergiong experimentally induced ethanol intoxication. Psychosom. Med. 28, 1–12 (1966).
— —, Mello, N. K.: Effects of experimentally induced intoxication on metabolism of ethanol-1-C14 in alcoholic subjects. Metabolism 14, 1255–1266 (1965).
Moran, L. J., Mefferd, R. B.: Repetitive psychometric measures. Psychol. Rep. 5, 269–276 (1959).
Ritchie, J. M.: The aliphatic alcohols, pp. 143–153. In: L. Goodman, and A. Gilman. The Pharmacological Basis of Therapeutics, 3rd Edit. New York: The Macmillan Comp. 1965.
Wilson, L., Taylor, J. D., Nash, C. W., Cameron, D. F.: The combined effects of ethanol and amphetamine sulfate on performance of human subjects. Canad. med. Ass. J. 9, 478–484 (1966).
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Sidell, F.R., Pless, J.E. Ethyl alcohol: Blood levels and performance decrements after oral administration to man. Psychopharmacologia 19, 246–261 (1971). https://doi.org/10.1007/BF00401941
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DOI: https://doi.org/10.1007/BF00401941