Abstract
The relationships between drug dosage per injection and response rate, and drug dosage per injection and total daily drug intake were ascertained in Rhesus monkeys which self-administered cocaine, pipradrol, methylphenidate and phenmetrazine intravenously. The study demonstrated the monkeys would self-administer all of these compounds over a wide range of dosages. Furthermore, the magnitude of reinforcement, i.e., dosage per injection, and the rate of responding in self-administering these compounds were inversely related. However, total daily drug intake was independent of the dosage per injection over a wide range of dosages. The results indicate that either the subjects can compensate for large changes in unit dosage so that daily drug intake remains stable or that a direct effect of these compounds functions in limiting their self-administration.
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This study was supported by NIMH Grant No. 5 R 10MH-12084 and by NIMH Grant No. MH-18245-01.
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Wilson, M.C., Hitomi, M. & Schuster, C.R. Psychomotor stimulant self administration as a function of dosage per injection in the Rhesus monkey. Psychopharmacologia 22, 271–281 (1971). https://doi.org/10.1007/BF00401789
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DOI: https://doi.org/10.1007/BF00401789