Abstract
Muscimol is a weak, non-competitive inhibitor (K i 1.2×10−3 M) of the uptake of γ-aminobutyric acid by slices of rat cerebral cortex.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bloom, F. E., Iversen, L. L.: Localizing 3H-GABA in nerve terminals of rat cerebral cortex by electron microscopic autoradiography. Nature (Lond.) 229, 628–630 (1971).
Curtis, D. R., Duggan, A. W., Felix, D., Johnston, G. A. R.: GABA, bicuculline and central inhibition. Nature (Lond.) 226, 1222–1224 (1970).
— —, Johnston, G. A. R.: The inactivation of extracellularly administered amino acids in the feline spinal cord. Exp. Brain. Res. 10, 447–462 (1970).
—, Johnston, G. A. R.: Amino acid transmitters. In: Handbook of Neurochemistry. vol. 4, pp. 115–134. A. Lajtha, ed. New York: Plenum Press 1970.
Eugster, C. H.: Isolation, structure and syntheses of central-active compounds from Amanita muscaria (L. ex Fr.) Hooker. In: Ethnopharmacologic search for psychoactive drugs, pp. 416–418. D. H. Efron, B. Holmstedt, N. S. Kline, eds. Washington: U.S. Public Health Service publication no. 1645 (1967).
Iversen, L. L., Johnston, G. A. R.: GABA uptake in rat CNS: comparison of uptake in slices and homogenates and the effects of some inhibitors. J. Neurochem. (accepted for publication) (1971).
—, Neal, M. J.: The uptake of (3H)GABA by slices of rat cerebral cortex. J. Neurochem. 15, 1141–1149 (1968).
Johnston, G. A. R., Curtis, D. R., de Groat, W. C., Duggan, A. W.: Central actions of ibotenic acid and muscimol. Biochem. Pharmacol. 17, 2488–2489 (1968).
Neal, M. J., Iversen, L. L.: Subcellular distribution of endogenous and (3H)-γ-aminobutyric acid in rat cerebral cortex. J. Neurochem. 16, 1245–1252 (1969).
—, Pickles, H. G.: Uptake of 14C-glycine by spinal cord. Nature (Lond.) 222, 679–680 (1969).
Scotti de Carolis, A., Lipparini, F., Longo, V. G.: Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria. Psychopharmacologia (Berl.) 15, 186–195 (1969).
Theobald, W., Buch, O., Kunz, H. A., Krupp, P., Stenger, E. G., Heimann, H.: Pharmakologische und experimental-psychologische Untersuchungen mit 2 Inhaltsstoffen des Fliegenpilzes (Amanita muscaria). Arzneimittel-Forsch. 18, 311–315 (1968).
Waser, P. G.: The pharmacology of Amanita muscaria. In: Ethnopharmacologic search for psychoactive drugs, pp. 419–439. D. H. Efron, B. Holmstedt, N. S. Kline, eds. Washington: U.S. Public Health Service publication no. 1645 (1967).
Author information
Authors and Affiliations
Additional information
On leave from the Department of Physiology, Australian National University, Canberra, Australia.
Rights and permissions
About this article
Cite this article
Johnston, G.A.R. Muscimol and the uptake of γ-aminobutyric acid by rat brain slices. Psychopharmacologia 22, 230–233 (1971). https://doi.org/10.1007/BF00401785
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00401785