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Self-administration of d-amphetamine by rats

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Summary

Self-administration of d-amphetamine by rats was characterized by periods of drug intake and abstinence. Frequency of responding for drug injection was found to vary inversely as a function of drug dose per infusion (magnitude of reinforcement), and directly as a function of number of responses required per infusion (fixed-ratio reinforcement schedule). In several regards, reinforcement by d-amphetamine resembled that produced by electrical stimulation of the brain.

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Authors and Affiliations

  1. Department of Pharmacology, Psychiatry and Neurology, University of Minnesota Medical School, Mayo, Box 390, 55455, Minneapolis, Minnesota, USA

    Roy Pickens

Authors
  1. Roy Pickens
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  2. Wayne C. Harris
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Additional information

This research was supported in part by grants MH-08565, MH-11135, and MH-14112 from U.S.P.H.S. to the University of Minnesota.

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Pickens, R., Harris, W.C. Self-administration of d-amphetamine by rats. Psychopharmacologia 12, 158–163 (1968). https://doi.org/10.1007/BF00401545

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  • DOI: https://doi.org/10.1007/BF00401545

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