Summary
Different groups of mice were exposed to flurothyl vapors immediately 5, 60, 360, and 720 min after a one-trial passive avoidance learning procedure. The first three groups 24 hours later showed a marked retention deficit, but retest performance of the 6 hour group was significantly less impaired than the first three. The 12 hour group was not significantly different from the control group. When only clonic seizures were elicited, performance was just as impaired as in mice which had exhibited tonic convulsions. The effective intervals at which RA was produced were similar for both flurothyl and ECS. However, the temporal gradient of RA to the flurothyl treatment was significantly flatter than that produced by a 15 mA-ECS under otherwise identical conditions.
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Bohdanecky, Z., Kopp, R. & Jarvik, M.E. Comparison of ECS and flurothyl-induced retrograde amnesia in mice. Psychopharmacologia 12, 91–95 (1968). https://doi.org/10.1007/BF00401537
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DOI: https://doi.org/10.1007/BF00401537