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Tolerance and cross-tolerance among psychotomimetic drugs

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Summary

A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance was also demonstrated.

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Authors and Affiliations

  1. Department of Psychiatry, The University of Chicago, USA

    J. B. Appel & D. X. Freedman

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  1. J. B. Appel
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  2. D. X. Freedman
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Additional information

This research was supported by Public Health Service Research Grant, MH-03363, from the National Institute of Mental Health.

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Appel, J.B., Freedman, D.X. Tolerance and cross-tolerance among psychotomimetic drugs. Psychopharmacologia 13, 267–274 (1968). https://doi.org/10.1007/BF00401404

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  • DOI: https://doi.org/10.1007/BF00401404

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