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Similar structural bases for the storage and release of secretory material in adreno-medullary and β pancreatic cells

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Summary

Both in normal pancreatic β cells and in the adrenal medulla discontinuities have frequently been observed in the individual membranes surrounding secretion granules. In the β cells the edges of these hiatuses are characteristically inverted in the manner of a scroll. It is suggested that intracytoplasmic release of secretory material may occur through these membrane perforations.

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References

  • Bennet, H. S.: Cytological manifestations of secretion in the adrenal medulla of the cat. Amer. J. Anat. 69, 333–381 (1941).

    Google Scholar 

  • Blaschko, H., G. V. R. Born, A. D'Iorio, and N. R. Eade: Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medulla. J. Physiol. (Lond.) 133, 548–557 (1956).

    Google Scholar 

  • Coupland, R. E.: Electron microscopic observations on the structure of the rat adrenal medulla. 1. The ultrastructure and organisation of chromaffin cells in the normal adrenal medulla. J. Anat. (Lond.) 99, 231–254 (1965).

    Google Scholar 

  • De Robertis, E. D. P., and D. D. Sabatini: Submioroscopic analysis of the secretory process in the adrenal medulla. Fed. Proc. 19, Suppl. 5, 70–78 (1960).

    PubMed  Google Scholar 

  • Farquhar, M. G.: Origin and fate of secretory granules in cells of the anterior pituitary gland. Trans. N. Y. Acad. Sci. 23, 346–351 (1961).

    PubMed  Google Scholar 

  • Ferreira, D.: L'ultrastructure des cellules du pancréas endocrine chez L'embryon et le rat nouveau-né. J. Ultrastruct. Res. 1, 14–25 (1957).

    PubMed  Google Scholar 

  • Hartroft, W. S., and G. A. Wrenshall: Correlation of β-cell granulation with extractable insulin of the pancreas. Studies in adult human diabetics and non-diabetics. Diabetes 4, 1–7 (1955).

    PubMed  Google Scholar 

  • Lacy, P. E.: Electron microscopic identification of different cell types in the islets of Langerhans of the guinea-pig, rat, rabbit and dog. Anat. Rec. 128, 255–261 (1957a).

    PubMed  Google Scholar 

  • —: Electron microscopy of the normal islets of Langerhans. Studies in the dog, rabbit, guineapig and rat. Diabetes 6, 498–507 (1957b).

    PubMed  Google Scholar 

  • —, and J. Davies: Preliminary studies on the demonstration of insulin in the islets by the fluorescent antibody technique. Diabetes 6, 354–357 (1957).

    PubMed  Google Scholar 

  • —, and W. S. Hartroft: Electron microscopy of the islets of Langerhans. Ann. N. Y. Acad. Sci. 82, 287–300 (1959).

    PubMed  Google Scholar 

  • Lever, J. D.: Electron microscopic observations on the normal and denervated adrenal medulla of the rat. Endocrinology 57, 621–635 (1955).

    PubMed  Google Scholar 

  • —: Fine structural appearances in relation to function in certain secretory organs. In: Electron microscopy in anatomy, p. 207–224. London: Arnold 1961.

    Google Scholar 

  • —, and R. Peterson: Cellular identities in the pars distalis of the rat pituitary. Trans. N. Y. Acad. Sci. 22, 504–508 (1960).

    PubMed  Google Scholar 

  • Munger, B. L.: The secretory cycle of the pancreatic islet α-cell. An electron microscopic study of normal and synthalin-treated rabbits. Lab. Invest. 11, 885–901 (1962).

    PubMed  Google Scholar 

  • Palade, G. E.: The secretory process of the pancreatic exocrine cell. In: Electron microscopy in anatomy, p. 176–206. London: Arnold 1961.

    Google Scholar 

  • Ratzenhofer, M., u. D. Leb: Über die Feinstruktur der argentaffinen und der anderen Erscheinungsformen der „Hellen Zellen“ Feyrters im Kaninchenmagen. Z. Zellforsch. 67, 113–150 (1965).

    PubMed  Google Scholar 

  • Reynolds, E. S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).

    Article  PubMed  Google Scholar 

  • Wetzstein, R.: Elektronenmikroskopische Untersuchungen am Nebennierenmark von Maus, Meerschweinchen und Katze. Z. Zellforsch. 46, 517–576 (1957).

    PubMed  Google Scholar 

  • Williamson, J. R., P. E. Lacy, and M. D. Grisham: Ultrastructural changes in the islets of the rat produced by tolbutamide. Diabetes 10, 460–469 (1961).

    PubMed  Google Scholar 

  • Yates, D. R.: An electron microscopic study of the effects of reserpine on adreno-medullary cells of the Syrian hamster. Anat. Rec. 146, 29–45 (1963).

    PubMed  Google Scholar 

  • —: A light and electron microscopic study correlating the chromaffin reaction and granule ultrastructure in the adrenal medulla of the Syrian hamster. Anat. Rec. 149, 237–249 (1964).

    PubMed  Google Scholar 

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Lever, J.D., Findlay, J.A. Similar structural bases for the storage and release of secretory material in adreno-medullary and β pancreatic cells. Zeitschrift für Zellforschung 74, 317–324 (1966). https://doi.org/10.1007/BF00401260

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