Summary
Both in normal pancreatic β cells and in the adrenal medulla discontinuities have frequently been observed in the individual membranes surrounding secretion granules. In the β cells the edges of these hiatuses are characteristically inverted in the manner of a scroll. It is suggested that intracytoplasmic release of secretory material may occur through these membrane perforations.
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Bennet, H. S.: Cytological manifestations of secretion in the adrenal medulla of the cat. Amer. J. Anat. 69, 333–381 (1941).
Blaschko, H., G. V. R. Born, A. D'Iorio, and N. R. Eade: Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medulla. J. Physiol. (Lond.) 133, 548–557 (1956).
Coupland, R. E.: Electron microscopic observations on the structure of the rat adrenal medulla. 1. The ultrastructure and organisation of chromaffin cells in the normal adrenal medulla. J. Anat. (Lond.) 99, 231–254 (1965).
De Robertis, E. D. P., and D. D. Sabatini: Submioroscopic analysis of the secretory process in the adrenal medulla. Fed. Proc. 19, Suppl. 5, 70–78 (1960).
Farquhar, M. G.: Origin and fate of secretory granules in cells of the anterior pituitary gland. Trans. N. Y. Acad. Sci. 23, 346–351 (1961).
Ferreira, D.: L'ultrastructure des cellules du pancréas endocrine chez L'embryon et le rat nouveau-né. J. Ultrastruct. Res. 1, 14–25 (1957).
Hartroft, W. S., and G. A. Wrenshall: Correlation of β-cell granulation with extractable insulin of the pancreas. Studies in adult human diabetics and non-diabetics. Diabetes 4, 1–7 (1955).
Lacy, P. E.: Electron microscopic identification of different cell types in the islets of Langerhans of the guinea-pig, rat, rabbit and dog. Anat. Rec. 128, 255–261 (1957a).
—: Electron microscopy of the normal islets of Langerhans. Studies in the dog, rabbit, guineapig and rat. Diabetes 6, 498–507 (1957b).
—, and J. Davies: Preliminary studies on the demonstration of insulin in the islets by the fluorescent antibody technique. Diabetes 6, 354–357 (1957).
—, and W. S. Hartroft: Electron microscopy of the islets of Langerhans. Ann. N. Y. Acad. Sci. 82, 287–300 (1959).
Lever, J. D.: Electron microscopic observations on the normal and denervated adrenal medulla of the rat. Endocrinology 57, 621–635 (1955).
—: Fine structural appearances in relation to function in certain secretory organs. In: Electron microscopy in anatomy, p. 207–224. London: Arnold 1961.
—, and R. Peterson: Cellular identities in the pars distalis of the rat pituitary. Trans. N. Y. Acad. Sci. 22, 504–508 (1960).
Munger, B. L.: The secretory cycle of the pancreatic islet α-cell. An electron microscopic study of normal and synthalin-treated rabbits. Lab. Invest. 11, 885–901 (1962).
Palade, G. E.: The secretory process of the pancreatic exocrine cell. In: Electron microscopy in anatomy, p. 176–206. London: Arnold 1961.
Ratzenhofer, M., u. D. Leb: Über die Feinstruktur der argentaffinen und der anderen Erscheinungsformen der „Hellen Zellen“ Feyrters im Kaninchenmagen. Z. Zellforsch. 67, 113–150 (1965).
Reynolds, E. S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).
Wetzstein, R.: Elektronenmikroskopische Untersuchungen am Nebennierenmark von Maus, Meerschweinchen und Katze. Z. Zellforsch. 46, 517–576 (1957).
Williamson, J. R., P. E. Lacy, and M. D. Grisham: Ultrastructural changes in the islets of the rat produced by tolbutamide. Diabetes 10, 460–469 (1961).
Yates, D. R.: An electron microscopic study of the effects of reserpine on adreno-medullary cells of the Syrian hamster. Anat. Rec. 146, 29–45 (1963).
—: A light and electron microscopic study correlating the chromaffin reaction and granule ultrastructure in the adrenal medulla of the Syrian hamster. Anat. Rec. 149, 237–249 (1964).
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Lever, J.D., Findlay, J.A. Similar structural bases for the storage and release of secretory material in adreno-medullary and β pancreatic cells. Zeitschrift für Zellforschung 74, 317–324 (1966). https://doi.org/10.1007/BF00401260
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DOI: https://doi.org/10.1007/BF00401260