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Westermark P (1972) Quantitative studies of amyloid in the islets of Langerhans. Upsala J Med Sci 77: 91–94
Westermark P, Grimelius L (1973) the pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults. Acta Path Microbiol Scand A 81: 291–300
Opie EL (1901) On the relation of chronic interstitial pancreatitis to the islands of Langerhans and to diabetes mellitus. J Exp Med 5: 397–428
Weichselbaum A, Stangl E (1901) Zur Kenntnis der feineren Veränderungen des Pankreas bei Diabetes mellitus. Wien Klin Wochenschr 14: 968–972
Glenner GG (1980) Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med 302: 1283–1292
Glenner GG (1980) Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med 302: 1333–1343
Westermark P (1973) Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch A 359: 1–18
Westermark P, Wernstedt C, Wilander E, Sletten K (1976) A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140: 827–831
Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 84: 3881–3885
Westermark P, Wernstedt C, O'Brien TD, Hayden DW, Johnson KH (1987) Islet amyloid in type 2 diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 127: 414–417
Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84: 8628–8632
Cooper GJS, Leighton B, Dimitriadis GD et al. (1988) Amylin found in amyloid deposits in type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle. Proc Natl Acad Sci USA 85: 7763–7766
Sanke T, Bell GI, Sample C, Rubenstein AH, Steiner DF (1988) An islet amyloid peptide is derived from an 89-amino acid pre-cursor by proteolytic processing. J Biol Chem 263: 17243–17246
Betsholtz C, Svensson V, Rorsman F et al. (1989) Islet amyloid polypeptide (IAPP): cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus. Exp Cell Res 183: 484–493
Mosselman S, Höppener JWM, Lips CJM, Jansz HS (1989) The complete islet amyloid polypeptide precursor is encoded by two exons. FEBS Lett 247: 154–158
Betsholtz C, Christmanson L, Engström U et al. (1989) Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. FEBS Lett 251: 261–264
Nishi M, Chan SJ, Nagamatsu S, Bell GI, Steiner DF (1989) Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc Natl Acad Sci USA 86: 5738–5742
Betsholtz C, Christmanson L, Engström U et al. (1990) Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation. Diabetes 39: 118–122
Nishi M, Sanke T, Nagamatsu S, Bell GI, Steiner DF (1990) Islet amyloid polypeptide. A new β-cell secretory product related to islet amyloid deposits. J Biol Chem 265: 4173–4176
Johnson KH, O'Brien TD, Hayden DW et al. (1988) Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. Am J Pathol 130: 1–8
Lukinius A, Wilander E, Westermark GT, Engström U, Westermark P (1989) Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 32: 240–244
Clark A, Edwards CA, Ostle LR et al. (1989) Localization of islet amyloid polypeptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects. Cell Tissue Res 257: 179–185
Nishi M, Sanke T, Seino S et al. (1989) Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history. Mol Endocrinol 3: 1775–1781
Christmanson L, Rorsman F, Stenman G, Westermark P, Betsholtz C (1990) The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region. FEBS Lett 267: 160–166
van Mansfeld ADM, Mosselman S, Höppener JWM et al. (1990) Islet amyloid polypeptide: structure and upstream sequences of the IAPP genes in rat and man. Biochim Biophys Acta 1087: 235–240
Mosselman S, Höppener JWM, Zandberg J et al. (1988) Islet amyloid polypeptide: identification and chromosomal localization of the human gene. FEBS Lett 239: 227–232
Cooper GJS, Day AJ, Willis AC, Roberts AN, Reid KBM, Leighton B (1989) Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus. Biochim Biophys Acta 1014: 247–258
Madsen O, Nielsen JH, Michelsen B et al. (1991) Islet amyloid polypeptide (IAPP/amylin) and insulin expression are controlled differently in primary and transformed islet cells. Mol Endocrinol 5: 143–148
Ferrier GJM, Pierson AM, Jones PM, Bloom SR, Girgis SI, Legon S (1989) Expression of the rat amylin (IAPP/DAP) gene. J Endocrinol 3: R1-R4
Nakazato M, Asai J, Kangawa K, Matsukura S, Matsuo H (1989) Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration. Biochem Biophys Res Commun 164: 394–399
Asai J, Nakazato M, Miyazato M, Kangawa K, Matsuo H, Matsukura S (1990) Regional distribution and molecular forms of rat islet amyloid polypeptide. Biochem Biophys Res Commun 169: 788–795
Toshimori H, Narita R, Nakazato M et al. (1990) Islet amyloid polypeptide (IAPP) in the gastrointestinal tract and pancreas of man and rat. Cell Tissue Res 262: 401–406
Leffert JD, Newgard CB, Okamoto H, Milburn JL, Luskey KL (1989) Rat amylin: cloning and tissue-specific expression in pancreatic islets. Proc Natl Acad Sci USA 86: 3127–3130
Johnson KH, O'Brien TD, Hayden DW, Mahoney WC, Wernstedt C, Westermark P (1988) Relationships of islet amyloid polypeptide (IAPP) to spontaneous diabetes in adult cats. In: Isobe T, Araki S, Uchino F, Kito S, Tsubura E (eds) Amyloid and Amyloidosis. Plenum Press, New York, pp 673–678
Kanatsuka A, Makino H, Ohsawa H et al. (1989) Secretion of islet amyloid polypeptide in response to glucose. FEBS Lett 259: 199–201
Nakazato M, Miyazato M, Asai J et al. (1990) Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation. Biochem Biophys Res Commun 169: 713–718
Sanke T, Hanabusa T, Nakano Y et al. (1991) Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 34: 129–132
Hartter E, Svoboda T, Ludvik B et al. (1991) Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans. Diabetologia 34: 52–54
Fehmann HC, Weber V, Göke R, Göke B, Arnold R (1990) Cosecretion of amylin and insulin from isolated rat pancreas. FEBS Lett 262: 279–281
Butler P, Chou J, Carter WB et al. (1990) Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans. Diabetes 39: 752–756
Inoue K, Hisatomi A, Umeda F, Nawata H (1990) Amylin release from perfused rat pancreas in response to glucose and arginine. Diab Res Clin Pract 10: 189–192
Mitsukawa T, Takemura J, Asai J et al. (1990) Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration. Diabetes 39: 639–642
Kahn SE, D'Alessio DA, Schwartz MW et al. (1990) Evidence of cosecretion of islet amyloid polypeptide and insulin by β-cells. Diabetes 39: 634–638
Bretherton-Watt D, Ghatei MA, Jamal H et al. (1989) Altered islet amyloid polypeptide (IAPP) gene expression in rat models of diabetes. Diabetologia 32: 881–883
O'Brien TD, Westermark P, Johnson KH (1991) Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated and dexamethasone-treated rats. Diabetes 40: 1701–1706
van Jaarsveld BC, Hackeng WHL, Niewenhuis MG, Erkelens DW, Geerdink RA, Lips CJM (1990) Islet amyloid polypeptide in human plasma. Lancet I: 60
Bretherton-Watt D, Gilbey SG, Ghatei MA, Beacham J, Bloom SR (1990) Failure to establish islet amyloid polypeptide (amylin) as a circulating Beta-cell inhibiting hormone in man. Diabetologia 33: 115–117
Westermark P, Johnson KH (1988) The pathogenesis of maturity-onset diabetes mellitus: is there a link to islet amyloid polypeptide? BioEssays 9: 30–33
Westermark P, Wilander E, Westermark GT, Johnson KH (1987) Islet amyloid polypeptide-like immunoreactivity in the islet B cells of Type 2 (non-insulin-dependent) diabetic and non-diabetic individuals. Diabetologia 30: 887–892
Johnson KH, O'Brien TD, Jordan K, Westermark P (1989) Impaired glucose tolerance is associated with increased islet amyloid polypeptide (IAPP) immunoreactivity in pancreatic beta cells. Am J Pathol 135: 245–250
Gill AM, Yen TT (1991) Effects of ciglitazone on endogenous plasma islet amyloid polypeptide and insulin sensitivity in obese-diabetic viable yellow mice. Life Sci 48: 703–710
Ogawa A, Harris V, McCorkie SK, Unger RH, Luskey KL (1990) Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment. J Clin Invest 85: 973–976
Jamal H, Bretherton-Watt D, Suda K, Ghatei MA, Bloom SR (1990) Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin. J Endocrinol 126: 425–429
Ohsawa H, Kanatsuka A, Yamaguchi T, Makino H, Yoshida S (1989) Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets. Biochem Biophys Res Commun 160: 961–967
Silvestre RA, Peiró E, D'gano P, Miralles P, Marco J (1990) Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas. Regul Pept 31: 23–31
Ghatei MA, Datta HK, Zaidi M et al. (1990) Amylin and amylinamide lack an acute effect on blood glucose and insulin. J Endocrinol 124: R9-R11
Nagamatsu S, Carrol RJ, Grodsky GM, Steiner DF (1990) Lack of islet amyloid polypeptide regulation of insulin biosynthesis or secretion in normal rat islets. Diabetes 39: 871–874
O'Brien TD, Westermark P, Johnson KH (1990) Islet amyloid polypeptide (IAPP) does not inhibit glucose-stimulated insulin secretion from isolated perfused rat pancreas. Biochem Biophys Res Commun 170: 1223–1228
Fehmann H-C, Weber V, Göke R, Göke B, Eissele R, Arnold R (1990) Islet amyloid polypeptide (IAPP; amylin) influences the endocrine but not the exocrine rat pancreas. Biochem Biophys Res Commun 167: 1102–1108
Pettersson M, Ahrén B (1988) Insulin and glucagon secretion in rats: effects of calcitonin gene-related peptide. Regul Pept 23: 37–50
Johnson KH, O'Brien TD, Jordan K, Betsholtz C, Westermark P (1990) The putative hormone islet amyloid polypeptide (IAPP) induces impaired glucose tolerance in cats. Biochem Biophys Res Commun 167: 507–513
Sowa R, Sanke T, Hirayama J et al. (1990) Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs. Diabetologia 33: 118–120
Frontoni S, Bong Choi S, Banduch D, Rossetti L (1991) In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle. Diabetes 40: 568–573
Koopmans SJ, van Mansfeld ADM, Jansz HS et al. (1991) Amylin-induced in vivo resistance in conscious rats: the liver is more sensitive to amylin than peripheral tissues. Diabetologia 34: 218–224
Leighton B, Cooper GJS (1988) Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro. Nature 335: 632–635
Leighton B, Foot E (1990) The effects of amylin on carbohydrate metabolism in skeletal muscle in vitro and in vivo. Biochem J 269: 19–23
Hothersall JS, Muirhead RP, Wimalawansa S (1990) The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm. Biochem Biophys Res Commun 169: 451–454
Zierath JR, Galuska D, Engström Å et al. (1992) Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester-stimulated glucose transport in in vitro incubated human muscle strips. Diabetologia 35: 26–31
Deems RO, Deacon RW, Young DA (1991) Amylin activates glycogen phosphorylase and inactivates glycogen synthase via a cAMP-independent mechanism. Biochem Biophys Res Commun 174: 716–720
Young AA, Mott DM, Stone K, Cooper GJS (1991) Amylin activates glycogen phosphorylase in the isolated soleus muscle of the rat. FEBS Lett 281: 149–151
Morishita T, Yamaguchi A, Fujita T, Chiba T (1990) Activation of adenylate cyclase by islet amyloid polypeptide with COOH-terminal amide via calcitonin gene-related peptide receptors on rat liver plasma membranes. Diabetes 39: 875–877
Galeuzza MT, O'Brien TD, Johnson KH, Seybold KS (1991) Islet amyloid polypeptide (IAPP) competes for two binding sites of CGRP. Peptides 12: 585–591
Stephens TW, Heath WF, Hermeling RN (1991) Presence of liver CGRP/Amylin receptors in only nonparenchymal cells and absence of direct regulation of rat liver glucose metabolism by CGRP/amylin. Diabetes 40: 395–400
Datta HK, Zaidi M, Wimlawansa SJ et al. (1989) In vivo and in vitro effects of amylin and amylin-amide on calcium metabolism in the rat and rabbit. Biochem Biophys Res Commun 162: 876–881
Brain SD, Wimalawansa S, MacIntyre I, Williams TJ (1990) The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit. Am J Pathol 136: 487–490
Chance WT, Balasubramaniam A, Zhang FS, Wimalawansa SJ, Fischer JE (1991) Anorexia following the intrahypothalamic administration of amylin. Brain Res 539: 352–354
Nishi M, Bell GI, Steiner DF (1990) Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 33: 628–630
Westermark P, Engström U, Johnson KH, Westermark GT, Betsholtz C (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87: 5036–5040
Breeze AL, Harvey TS, Bazzo R, Campbell ID (1991) Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics. Biochemistry 30: 575–582
Glenner GG, Eanes ED, Wiley CA (1988) Amyloid fibril formed from a segment of the pancreatic islet amyloid protein. Biochem Biophys Res Commun 155: 608–614
Westermark P, Johnson KH, Engström U, Westermark GT, Betsholtz C (1991) Islet amyloid polypeptide: synthetic peptides for study of the pathogenesis of islet amyloid. In: Natvig JB, Förre Ö, Husby G et al. (eds) Amyloid and amyloidosis 1990. Kluwer Academic Publishers. Dordrecht, pp 449–452
Betsholtz C, Johnson KH, Westermark P (1989) “Amylin” hormone. Nature 338: 211
Johnson KH, Wernstedt C, O'Brien TD, Westermark P (1991) Amyloid in the pancreatic islets of the cougar (Felis concolor) is derived from islet amyloid polypeptide (IAPP). Comp Biochem Physiol 98B: 115–119
Jordan K, Murtaugh MP, O'Brien TD, Westermark P, Betsholtz C, Johnson KH (1990) Canine IAPP cDNA sequence provides important clues regarding diabetogenesis and amyloidogenesis in type 2 diabetes. Biochem Biophys Res Commun 169: 502–508
O'Brien TD, Westermark P, Johnson KH (1990) Islet amyloid polypeptide and calcitonin gene-related peptide immunoreactivity in amyloid and tumor cells of canine pancreatic endocrine tumors. Vet Pathol 27: 194–198
Westermark P, Engström U, Westermark GT, Johnson KH, Permerth J, Betsholtz C (1989) Islet amyloid polypeptide (IAPP) and pro-IAPP immunoreactivity in human islets of Langerhans. Diab Res Clin Pract 7: 219–226
Cook JTE, Patel PP, Clark A et al. (1991) Non-linkage of the islet amyloid polypeptide gene with Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34: 103–108
Nakazato M, Asai J, Miyazato M, Matsukura S, Kangawa K, Matsuo H (1990) Isolation and identification of islet amyloid polypeptide in normal human pancreas. Regul Pept 31: 179–186
Westermark P, Wilander E (1978) The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15: 417–421
Howard CF Jr (1978) Insular amyloidosis and diabetes mellitus in Macaca nigra. Diabetes 27: 357–364
Maloy AL, Longnecker DS, Greenberg ER (1981) The relation of islet amyloid to the clinical type of diabetes. Hum Pathol 12: 917–922
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Westermark, P., Johnson, K.H., O'Brien, T.D. et al. Islet amyloid polypeptide — a novel controversy in diabetes research. Diabetologia 35, 297–303 (1992). https://doi.org/10.1007/BF00401195
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DOI: https://doi.org/10.1007/BF00401195