Summary
Tumorigenicity of isoniazid (INH) and hydrazine sulfate (HS) was studied in male and virgin Swiss mice. The INH and HS induced 50% und 84% lung tumors in males and 67% and 72% in females, respectively. Both chemicals induced lung tumors in animals of the F1 generation that were exposed to INH or HS during intrauterine life, lactation, and in the postweaning period. Surprisingly, the F2 generation from these F1 animals, which were exposed to INH only during gestation and lactation, showed earlier and much higher tumor incidence than the parent generation.
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References
Adams JF (1978) Mutagenicity of some environmental chemicals in Salmonella microsomal activation test systems. Mutat Res 53:142 (Abstract No 3)
Bhide SV, Maru GB, Sawai MM, Ranadive KJ (1978) Isoniazid tumorigenicity in mice under different experimental conditions. Int J Cancer 21:381–386
Biancifiori C, Severi L (1966) The relation of isoniazid (INH) and allied compounds to carcinogenesis in some species of small laboratory animals. A Review. Br J Cancer 20:528–536
Brent RL, Franklin JB (1960) Uterine vascular clamping. New procedure for the study of congential malformations. Science 132:80–90
Bulay OM, Watternberg LW (1970) Carcinogenic effects of subcutaneous administration of benzo (a) pyrene during pregnancy on the progeny. Proc Soc Exp Biol Med 135:84–86
Currie AR, Bird CC, Crawford AM, Sims P (1970) Embryopathic effects of 7,12-dimethyl benzanthracene and its hydroxymethyl derivatives in the sprague Dawley rat. Nature 226:918
Diwan BA, Meier H, Huebner RJ (1974) Transplacental effects of 1-ethyl nitrosourea in inbred strains on mice. IV. Rapid tumor induction in strain crosses. J Natl Cancer Inst 52:893–897
Druckrey H, Ivankovic S, Preussmann R (1966) Teratogenic and carcinogenic effects in the offspring after single injection of ethyl nitrosourea to pregnant rats. Nature 20:1378–1381
Greenwald R, Barlow JJ, Nasca P (1971) Vaginal cancer after maternal treatment with synthetic estrogens. N Engl J Med 285:390–392
Herbst AL, Ulfelder H, Poskanser DC (1971) Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878–881
Higginson J, Muir CS (1973) In: Holland JF, Frei E (eds) Cancer medicine, 3rd edn (p. 241)
Ivankovic S (1979) Teratogenic and carcinogenic effects of chemicals during prenatal life in rats, syrian golden hamster and minipigs. Natl Cancer Inst Monogr. 51:103–115
Menon MM, Bhide SV (1980) Transplacental, biological and metabolic effecgs of isonializ (INH) in mice. Indian J Exp Biol 18:1104–1106
Menon MM, Bhide SV (1982) Transplacental, passage of isoniazid and its interaction with fetal tissues. Biochem Pharmacol (in press)
Rohrborn G (1970) The activity of alkylating agents and oogenesis. In: Vogel, Rohrborn G (eds) Chemical mutagenesis in mammals and man. Springer Berlin Heidelberg New York pp 295–316
Tomatis L (1979) Prenatal exposure to chemical carcinogens and its effect on subsequent generations. Natl Cancer Inst Monogr 51:159–184
Tomatis L, Goodall C (1969) The occurrence of tumors in F1, F2, and F3 descendants of pregnant mice injected with 7,12-dimethyl benz (a) anthracene. Int. J. Cancer 4:219–225
Tomatis L, Hilfrich J, Turusov V (1975) The occurrence of tumors in F1, F2, and F3 descendants of BD rats exposed to N-nitrosomethyl urea during pregnancy. Int J Cancer 150:385–390
Tomatis L, Turusov V, Guibbert D et al. (1971) Transplacental carcinogenic effect of 3-methyl cholanthrene in mice and its quantitation in fetal tissues. J Natl Cancer Inst 47:645–651
Tosk J, Sehmeltz I, Hoffmann D (1979) Hydrazines as mutagens in a histidine requiring auxotroph of salmonella typhimurium. Mutat Res 66:247–252
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Menon, M.M., Bhide, S.V. Perinatal carcinogenicity of isoniazid (INH) in swiss mice. J Cancer Res Clin Oncol 105, 258–261 (1983). https://doi.org/10.1007/BF00395754
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DOI: https://doi.org/10.1007/BF00395754