Summary
Five cases, four histologically proven, of hamartoma of the tuber cinereum and hypothalamus in children are reported. The ages of the patients range from 2 to 12 years. Three cases had pubertas praecox, and in all of these the hamartoma was located in the basal cistern between the chiasm and pons and had a collar button shape and size typical of hamartoma of the tuber cinereum. In the third case, a huge calcified mass in the suprasellar region was initially thought to be craniopharyngioma. The fourth case had a hamartoma within the substance of the hypothalamus and presented with hyponatremia and temporal lobe seizures.
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Bedwell, S.F., Lindenberg, R.: A hypothalamic hamartoma with dendritic proliferation and other neuronal changes associated with blastomoid reaction of astroxytes. J. Neuropathol. Exp. Neurol. 20, 219–236 (1961)
Bustamente, M.: Experimentelle Untersuchungen über die Leistungen des Hypothalamus, besonders bezüglich der Geschlechtsreifung. Arch. Psychiatr. 115, 419–468 (1942)
Judge, D.M., Kulin, H.E., Page, R., Santen, R., Trapukdi, S.: Hypothalamic hamartoma. A source of luteinizing — hormone-releasing factor in precocious puberty. N. Engl. J. Med. 296, 7–10 (1977)
List, C.F., Dowman, C.E., Bagchi, B.K., Bebin, J.: Posterior hypothalamic hamartoma and ganglioglioma causing precocious puberty. Neurology 8, 164–174 (1958)
McCullagh, E.P., Rosenberg, H.S., Norman, H.: Tumor of tuber cinereum with precocious puberty: Case report with hormone assays. J. Clin. Endocrinol. 20, 1286–1293 (1960)
Richter, R.B.: True hamartoma of the hypothalamus associated with pubertas praecox. J. Neuropathol. Exp. Neurol. 10, 368–383 (1951)
Stotijn, C.P.J., Nauta, W.J.H.: Precocious puberty and tumor of the hypothalamus. Report of a case and review of the literature and a consideration of the hypothalamus-hypophyseal connections. J. Nerv. Ment. Dis. 111, 207–224 (1950)
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Lin, SR., Bryson, MM., Gobien, R. et al. Neuroradiologic study of hamartomas of the tuber cinereum and hypothalamus. Neuroradiology 16, 17–19 (1978). https://doi.org/10.1007/BF00395190
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DOI: https://doi.org/10.1007/BF00395190