Skip to main content
SpringerLink
Log in

Autotoxic antibiotic production by a marine Chromobacterium

  • Published:
Marine Biology Aims and scope Submit manuscript

Abstract

An antibiotic-producing Chromobacter was isolated from a sea-water sample from the North Pacific Gyre. The bacterium produces 3 bromine-containing metabolites: tetrabromopyrrole, 2-(2′-hydroxy-3′, 5′-dibromophenyl)-3, 4, 5-tribromopyrrole, and hexabromo-2, 2′-bipyrrole. It also synthesizes n-propyl 4-hydroxybenzoate and 4-hydroxybenzaldehyde. Some of these compounds were shown to be responsible for autoinhibition of the Chromobacterium itself, as well as for antibiotic action against other kinds of bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  • Buck, J.D., S.P. Meyers and K.M. Kamp: Marine bacteria with antiyeast activity. Science, N.Y. 138, 1339–1340 (1962)

    Google Scholar 

  • Burkholder, P.R.: Biology and geology of coral reefs. Vol. II. In: The ecology of marine antibiotics and coral reefs, pp 117–182. Ed. by O.A. Jones and R. Endean. New York: Academic Press 1973

    Google Scholar 

  • —, R.M. Pfister and F.M. Leitz: Production of a pyrrole antibiotic by a marine bacterium. Appl. Microbiol. 14, 649–653 (1966)

    Google Scholar 

  • Collins, C.H.: Microbial methods, 404 pp. New York: Plenum Press 1967

    Google Scholar 

  • Feiser, L.F. and M. Feiser: Reagents for organic synthesis. Vol. I. 1457 pp. New York: Wiley and Sons, Inc. 1968

    Google Scholar 

  • Gibbs, B.M. and F.A. Skinner: Identification methods for microbiologists, Part A. 145 pp. New York: Academic Press 1966

    Google Scholar 

  • Hamilton, R.D. and K.E. Austin: Physiological and cultural characteristics of Chromobacterium marinum. Antonie van Leeuwenhoek 33, 257–263 (1967)

    Google Scholar 

  • Hanessian, S. and J. Kaltenbronn: Synthesis of a bromine-rich antibiotic. J. Am. chem. Soc. 88, 4509–4510 (1966)

    Google Scholar 

  • Lovell, F.M.: The structure of a bromine-rich antibiotic. J. Am. chem. Soc. 88, 4510–4511 (1966)

    Google Scholar 

  • Palmer, M.H.: The structure and reactions of heterocyclic compounds, 462 pp. New York: St. Martins Press 1967

    Google Scholar 

  • Rapoport, H. and N. Castagnoli: 2,2′-bipyrrole. J. Am. chem. Soc. 84, 2178–2181 (1962)

    Google Scholar 

  • Rosenfeld, W.D. and C.E. Zobell: Antibiotic production by marine microorganisms. J. Bact. 54, 393–398 (1947)

    Google Scholar 

  • Sneath, P.H.A.: Cultural and biochemical characteristics of the genus Chromobacterium. J. gen. Microbiol. 15, 70–98 (1956)

    Google Scholar 

  • Williams, P.R. and W.R. Hearn: Antibiotics. Vol. II. Biosynthesis, 410–432. Ed. by D. Gottlieb and P.D. Shaw. New York: Springer Verlag 1967

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA

    R. J. Andersen, M. S. Wolfe & D. J. Faulkner

Authors
  1. R. J. Andersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. S. Wolfe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. J. Faulkner
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Communicated by J. Bunt, Miami

Rights and permissions

Reprints and permissions

About this article

Cite this article

Andersen, R.J., Wolfe, M.S. & Faulkner, D.J. Autotoxic antibiotic production by a marine Chromobacterium . Mar. Biol. 27, 281–285 (1974). https://doi.org/10.1007/BF00394363

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00394363

Keywords

Search

Navigation