Summary
The literature published between 1965 and 1989 on the cancer epidemiology of woodworking in furniture industries and carpentry shops in 17 countries ist reviewed. Included are some unpublished data obtained through personal communication with epidemiologists or collected from doctoral dissertations. Of 5,785 cases with sino-nasal cancers, about 23% were found to be woodworkers. Dusty jobs, expecially wood processing using high-speed machines, are mainly associated with the enhanced incidence of nasal adenocarcinomas. The latency periods of the latter tumors ranged from 7 to 69 years in five European countries. A variety of neoplasias of the respiratory, digestive, and urinary tracts as well as the hemopoietic and lymphatic systems, including Hodgkin's disease are reported to be significantly associated with occupational exposure to wood dust. These data suggest that the exposure to some types of wood dust might cause a systemic rather than local neoplastic disorder.
References
Abramson JH, Pridan H, Sacks MI, Avitzour M, Peritz E (1978) A case-control study of Hodgkin's disease in Israel. J Natl Cancer Inst 61:307–314
Acheson ED (1967) Hodgkin's disease in woodworkers. Lancet II:988–989
Acheson ED (1976) Nasal cancer in the furniture and boot and shoe manufacturing industries. Prev Med 5:295–315
Acheson ED, Hadfield EH (1967) Carcinoma of the nasal cavity and accessory sinuses in woodworkers. Lancet I:311–312
Acheson ED, Cowell RH, Hadfield E, Macbeth RG (1968) Nasal cancer in woodworkers in the furniture industry. Br Med J 2:587–596
Acheson ED, Cowell RH, Rang E (1972) Adenocarcinoma of the nasal cavity and sinuses in England and Wales. Br J Ind Med 29:21–30
Acheson ED, Pippard EC, Winter PD (1984) Mortality of English furniture makers. Scand J Work Environ Health 10:211–217
Adenis PL, Vankemmel B, Egret G, Demaille A (1973) Adenocarcinomes de l'ethmoide chez les ouvriers exposes aux poussieres de bois. Arch Mal Prof Med Trav Secur Soc 34:644–646
Alderson M (1986) Occupational cancer. Butterworth, London, pp 156–161
Andersen HC, Solgaard J, Andersen J (1976) Nasal cancer and nasal mucus-transport rates in woodworkers. Acta Otolaryngol 82:263–265
Andersen HC, Andersen I, Solgaard J (1977) Nasal cancers, symptoms and upper airway function in woodworkers. Br J Ind Med 34:201–207
Arnould G (1978) A propos des tumeurs malignes ethmoidonasales l'etiologie professionnelle des adeno carcinomes chez les travailleurs du bois. Doctoral Dissertation, Universite Claude Bernard, Lyon, France
Ball MJ (1967) Nasal cancer and occupation in Canada. Lancet II:1089–1090
Ball MJ (1968) Nasal cancer in woodworkers. Br Med J 2:253
Battista G, Cavallucci F, Comba P, Quercia A, Vindigni C, Sartrelli E (1983) A case-referent study on nasal cancer and exposure to wood dust in the province of Siena, Italy. Scand J Work Environ Health 9:25–29
Blot WJ, Fraumeni JF (1976) Geographic patterns of lung cancer: industrial correlations. Am J Epidemiol 103:539–550
Blot WJ, Davies JE, Brown LM, Nordwall CW, Buiatti E, Ng A, Fraumeni JF (1982) Occupation and the high risk of lung cancer in northwest Florida. Cancer 50:364–371
Bolm-Audorff U, Vogel C, Ziegler H, Stegmaier C, Fehr R, Woitowitz HJ (1985) Tumorhaeufigkeit bei Beschaeftigten in Holzberufen: Ergebnisse einer Auswertung zweier Krebsregister. Verhdl Dtsch Ges Arbeitsmed 25:553–557
Brinton LA, Stone BJ, Blot WJ, Fraumeni JF (1976) Nasal cancer in U.S. furniture industry counties. Lancet II:628
Brinton LA, Blot WJ, Becker JA, Winn DM, Browder JP, Farmer JC, Fraumeni JF (1984) A case-control study of the nasal cavity and paranasal sinuses. Am J Epidemiol 119:896–906
Brownson RC, Reif JS (1988) A cancer registry-based study of occupational risk for lymphoma, multiple myeloma and leukaemia. Int J Epidemiol 17:27–32
Brugere J, Laurent M, Thank P, Brunin F, Bataini P (1981) Adenocarcinomas of the ethmoid. Arch Mal Prof Med Trav Secur Soc 42:305–307
Cabal C, Teyssier JM (1981) Cancer de l'ethmoid chez les travailleurs du bois. Arch Mal Prof Med Trav Secur Soc 42:303–305
Caroyer JM, Van Dessel F (1987) Le cancer des voies respiratoires superieures chez les travailleurs du bois. Acta Oto-Rhino Laryngol Belg 41:5–15
Cecchi F, Buiatti E, Kriebel D, Nastasi L, Santucci M (1980) Adenocarcinoma of the nose and paranasal sinuses in shoemakers and woodworkers in the province of Florence, Italy. Br J Ind Med 37:222–225
Coggon D, Pannett B, Osmond C, Acheson ED (1986) A survey of cancer and occupation in young and middle-aged men: I. Cancers of the respiratory tract. Br J Ind Med 43:332–338
Curtes JP, Trotel E, Bourdiniere J (1977) Les adenocarcinomes de l'ethmoide chez les travailleurs du bois. Arch Mal Prof Med Trav Secur Soc 38:773–786
Debois JM (1969) Tumoren van De Neusholte Bij Houtbewerkers. Tijdschr Geneeskd 25:92–93
Delemarre JF, Themans HH (1971) Het Adenocarcinoma van de Neusholten. Ned Tijdschr Geneeskd 115:688–690
Duclos LC, Dubreuil C, Contassot JC, Guilchard R, Arnould G (1979) Les adenocarcinomes ethmoido-nasux chez les travailleurs du bois. Arch Mal Prof Med Trav Secur Soc 40:909–917
Elwood JM (1981) Wood exposure and smoking: association with cancer of the nasal cavity and paranasal sinuses in British Columbia. Can Med Assoc J 15:1573–1577
Engzell U, Englund A, Westerholm P (1978) Nasal cancer associated with occupational exposure to organic dust. Acta Otolaryngol 86:437–442
Esping B, Axelson O (1980) A pilot study on respiratory and digestive tract cancer among woodworkers. Scand J Work Environ Health 6:201–205
Flodin U, Fredriksson M, Persson B, Axelson O (1988) Chronic lymphatic leukemia and engine exhausts, fresh wood, and DDT: a case-referent study. Br J Ind Med 45:33–38
Fombeur JP (1972) A propos de cas recents de tumeurs ethmoidomaxillaires chez les travailleurs du bois. Arch Mal Prof Med Trav Secur Soc 33:453–455
Fukuda K, Shibata A (1988) A case-control study of past history of nasal diseases and maxillary sinus cancer in Hokkaido, Japan. Cancer Res 48:1651–1652
Gadeberg CC, Hjelm-Hansen M, Sogaard H, Elbrond O (1984) Malignant tumors of the paranasal sinuses and nasal cavity. Acta Radiol Oncol 23:181–187
Gaillard de Collogny L, Champiex J, Catilina P, Lafaye M, Pottecher G, Chamoux A (1981) Andenocarcinome de l'ethmoide et des fosses nasales chez des travailleurs du bois. J Natl Med Trav 16:300–302
Gerhardsson MR, Norell SE, Kiviranta HJ, Ahlbom A (1985) Respiratory cancers in furniture workers. Br J Ind Med 42:403–405
Ghezzi I, Peasso R, Cortona G, Berrino F, Crosignani P, Baldasseroni A (1983) Incidenza del tumore maligno delle cavita nasali in 91 comuni della Brianza. Med Lav 74:88–96
Gibel W, Nischan P, Staneczek W (1985) Zur Frage eines Berufskrebses bei Karzinomen und ihrer Nebenhoehlen bei Holzstaubexponierten. Arch Geschwulstforsch 55:279–284
Gignoux MB, Gignoux B (1971) Cancer de l'ethmoide et categories socio-professionnelles. J Fr Otorhinolaryngol 20:1055–1056
Greenberg M (1986) Wood dust and cancer in man. Toxicity Ref 15:10–23
Grimm HG, Hartung M, Valentin H, Wolf J (1984) Ueber das Vorkommen von Adenokarzinomen der Nasenhaupt-und Nasennebenhoehlen bei Holzarbeitern. Arbeitsmed Sozialmed Praeventivmed Sonderheft 4:1–20
Grufferman S, Duong T, Cole P (1976) Occupation and Hodgkin's disease. J Natl Cancer Inst 57:1193–1195
Guinchard R (1972) Cancer de l'ethmoide et categories socio-professionnelles. Doctoral Dissertation, Universite Claude Bernard, Lyon, France
Hadfield EH (1970) A study of adenocarcinoma of the paranasal sinuses in woodworkers in the furniture industry. Ann R Coll Surg Engl 46:301–319
Hadfield EH, Macbeth RG (1971) Adenocarcinoms of ethmoids in furniture workers. Ann Otol Rhinol Laryngol 80:699–703
Haguenauer JP, Rommanet P, Duclos JC, Guinchard R (1977) Les cancers professionnels de l'ethmoide. Arch Mal Prof Med Trav Secur Soc 38:819–823
Haguenauer JP, Bourret J, Duclos JC, Dubreuil C, Arnould G (1979) Les cancers de l'ethmoide chez les travailleurs du bois. Arch Mal Prof Med Trav Secur Soc 40:422–423
Harrington JM, Blot WJ, Hoover RN, Housworth WJ, Heath W, Fraumeni JF (1978) Lung cancer in coastal Georgia: a death certificate analysis of occupation. J Natl Cancer Inst 60:295–298
Hayes RB, Raatgever JW, Bruyn A de (1984) Tumors of the nose and nasal sinuses: a case-control study. In: Proceedings of the 21 st International Congress of Occupational Medicine, Dublin, September 1984 (Abstract 33-2)
Hayes RB, Raatgever JW, Bruyn A de, Gerin M (1986) Cancer of the nasal cavity and paranasal sinuses, and formaldehyde exposure. Int J Cancer 37:487–492
Hernberg S, Westerholm P, Schultz-Larsen K, Degerth R, Kuosma E, Englund A, Engzell U, Sand Hansen H, Mutanen P (1983) Nasal and sinonasal cancer: connection with occupational exposures in Denmark, Finland and Sweden. Scand J Work Environ Health 9:315–326
Hoar Zahm S, Brownson RC, Chang JC, Davis JR (1989) Study of lung cancer histologic types, occupation, and smoking in Missouri. Am J Ind Med 15:565–578
Holliday MG, Dranitsaris P, Strahlendorf PW, Contala A, Engelhardt JJ (1985) Wood dust exposure in Ontario industry: the occupational health aspects. Program Development Unit, OHSB, Ontario Ministry of Labour, Ontario, Canada
Hommerich KW (1964) Die Geschwuelste der Nase und der Nasennebenhoehlen. In: Berndes J, Link R, Zollner F (eds) Hals-Nasen-Ohren Heilkunde, vol 1. Thieme, Stuttgart, pp 461–525
Imbus HR, Dyson WL (1987) A review of nasal cancer in furniture manufacturing and woodworking in North Carolina, the United States, and other countries. J Occup Med 29:734–740
Ironside P, Matthews J (1975) Adenocarcinoma of the nose and paranasal sinuses in woodworkers in the State of Victoria, Australia. Cancer 36:1115–1121
Kleinsasser O, Schroeder HG, Wolf J (1987) Adenokarzinome der inneren Nase nach Holzstaubexposition: Vorsorgemaßnahmen und Frühdiagnose. Arbeitsmed Sozialmed Praeventivmed 22:70–77
Klintenberg C, Olofsson J, Hellquist H, Soekjer H (1984) Adenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure. Cancer 54:482–488
Kraus H, Maassen W, Richarath W (1984) Joiners among 789 patients with tumors of the nose or lung. Berichte der Verhandlungen der Jahrestagung der Deutschen Gesellschaft fuer Hals-Nasen-Ohren, Universitaet Muenster
Loebe LP, Ehrhardt HP (1983) Das berufsbedingte Adenokarzinom der Nase und Nebenhoehlen bei Holzarbeitern. HNO-Praxis 8:183–188
Luboinski B, Marandas P (1975) Cancer de l'ethmoid: etiologie professionelle. Arch Mal Prof Med Trav Secur Soc 36:477–487
Macbeth R (1965) Malignant disease of the paranasal sinuses. J Otolaryngol 79:592–612
Marandas P, Schwab G, Lecointre F, Pene F, Vandenbrouck C (1981) Cancers de l'ethmoide. Role du travail du bois et aspects cliniques. Arch Mal Prof Med Trav Secur Soc 42:294–300
Merler E, Garnevale F, D'Andrea F, Macaccaro G, Pisa R, Capitanio A, Cavazzani M, Gentile A, Fantoni G (1981) Neoplasia delle fosse nasali e dei seni paranasali ed esposizione professionale a polvere di legno: casistica rilevata nei reparti O.R.L. degli ospedali della provincia di Verona. Med Lav 2:87–95
Milham SJ (1977) Neoplasia in the wood and pulp industry. Ann NY Acad Sci 271:294–300
Milham SJ (1983) Occupational mortality in Washington State, 1950–1979. U.S. Department of Health & Human Services, Cincinnati, Ohio
Milham SJ, Hesser JE (1967) Hodgkin's disease in woodworkers. Lancet II:136–137
Mohtashamipur E, Norpoth K (1983) Zur Frage beruflich bedingter Tumoren in der holzverarbeitenden Industrie. Arbeitsmed Sozialmed Praeventivmed 18:49–52
Morton WE, Treyve EL (1982) Histologic differences in occupational risks of lung cancer incidence. Am J Ind Med 3:441–457
Mosbech J, Acheson ED (1971) Nasal cancer in furniture-makers in Denmark. Dan Med Bull 18:34–35
Muir CS, Nectoux J (1980) Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. Clin Otolaryngol 5:195–211
Müller KM, Fisseler-Eckhoff A (1989) What's new in lung tumor heterogeneity? Pathol Res Pract 184:108–115
Olsen J, Sabroe S (1979) A follow up study of non-retired and retired members of the Danish carpenter/cabinetmakers trade union. Int J Epidemiol 18:375–382
Olsen JH (1988) Occupational risks of sinonasal cancer in Denmark. Br J Ind Med 45:329–335
Olsen JH, Jensen OM (1984) Nasal cancer and chlorophenols. Lancet I:47–48
Olsen JH, Moller H, Jensen OM (1988) Risks for respiratory and gastric cancer in wood-working occupations in Denmark. J Cancer Res Clin Oncol 114:420–424
Peterson GR, Milham SJ (1974) Hodgkin's disease mortality and occupational exposure to wood. J Natl Cancer Inst 53:957–958
Petiet G, Beaulieu L, Ponsin JM, Remy JP, Perrin C de, Ren G (1981) A propos de la pathologie des travailleurs du bois en lorraine. Arch Mal Prof Med Trav Secur Soc 42:311–316
Petronio L, Negro C, Bovenzi M, Stanta G (1983) Tumori delle fosse nasali e dei seni paranasali ed occupazione a trieste dal 1968–1980. Med Lav 74:97–105
Ronco G, Ciccone G, Mirabelli D, Troia B, Vineis P (1988) Occupation and lung cancer in two industrialized areas of northern Italy. Int J Cancer 41:354–358
Roush GC, Meigs JW, Kelly J, Flannery JT, Burdo H (1980) Sinonasal cancer and occupation: a case-control study. Am J Epidemiol 111:183–193
Ruettner JR, Makek M (1985) Mucinoese Adenokarzinome der Nasen- und Nasennebenhoehlen, eine Berufskrankheit? Schweiz Med Wochenschr 115:1838–1842
Sarvesvaran R, Bowen DA (1985) A subject for inquest: two cases of woodworkers' adenocarcinoma. Med Sci Law 25:63–66
Shanmugaratnam K, Sobin LH (1978) Histological typing of upper respiratory tract tumors. In: International Histological Classification of Tumors, vol 19. WHO, Geneva, pp 15–18
Siemiatycki J, Richardson L, Gerin M, Goldberg M, Dewar R, Desy M, Campbell S, Wacholder S (1986) Associations between several sites of cancer and nine organic dusts: results from an hypothesis-generating case-control study in Montreal, 1979–1983. Am J Epidemiol 123:235–249
Smetana R, Horak F (1983) Rhinogenes Adenokarzinom bei Holzarbeitern. Laryngol Rhinol Otol 62:74–76
Stellman SD, Garfinkel L (1984) Cancer mortality among wood-workers. Am J Ind Med 5:343–357
Swanson GM, Belle SH (1982) Cancer morbidity among wood-workers in the U.S. automotive industry. J Occup Med 24:315–319
Takasaka T, Kawamoto K, Nakamura K (1987) A case-control study of nasal cancers: an occupational survey. Acta Otolaryngol (Stockh) 435:136–142
Tola S, Hernberg S, Collan Y, Linderborg H, Korkala ML (1980) A case-control study of the etiology of nasal cancer in Finnland. Int Arch Occup Environ Health 46:79–85
Trotel E (1976) Adenocarcinome de l'ethmoide et travail du bois. Doctoral Dissertation, Universite de Rennes, France
Vader JP, Minder CE (1987) Die Sterblichkeit an Krebsen der Nasen- und Nasennebenhoehlen bei Schweizer Schreinern. Schweiz Med Wochenschr 117:481–486
Veltin J (1977) Enquete sur les cancers des fosses nasales et des cavites sinusiennes dans la region Lorraine. Arch Mal Prof Med Trav Secur Soc 38:701–706
Voss R, Stenersen T, Oppedal BR, Boysen M (1985) Sinonasal cancer and exposure to softwood. Acta Otolaryngol 99:172–178
Walter P, Stebler S, Schaffer P, Vetter JM, Guerbaoui M (1976) Epithelioma cylindrique des fosses nasales et sinus accessoires: etude anatomo-clinique de 26 observations. Ann Anat Pathol 21:463–476
Watson WL (1942) Cancer of paranasal sinuses. Laryngoscope 52:22–42
Wilhelmsson B (1985) Epidemiology of occupational nasal cancer an other occupational nasal problems caused by wood dust. Rhinology 23:106–108
Wilhelmsson B, Drettner B (1984) Nasal problems in wood furniture workers: a study of symptoms and physiological variables. Acta Otolaryngol 98:548–555
Wilhelmsson B, Hellquist H, Olofsson J, Klintenberg C (1985) Nasal cuboidal metaplasia with dysplasia: precursor to adenocarcinoma in wood-dust-exposed workers? Acta Otolaryngol 99:641–648
Wills JH (1982) Nasal carcinoma in woodworkers: a review. J Occup Med 24:526–530
Wolf J, Hartung M, Schaller KH, Kochem W, Valentin H (1986) Das Vorkommen von Adenokarzinomen der Nasenhaupt-und Nasennebenhoehlen bei Holzarbeitern: weitere Untersuchungen (II). Arbeitsmed Sozialmed Praeventivmed Sonderheft 7:3–22
Wolf J (1987) Untersuchung über boesartige Tumoren der Nase und ihre Beziehung zur Holzstaubexposition in der Bundesrepublik Deutschland: Sicherheitswissenschaftlich-arbeitsmedizinische Systemanalyse mit Auswertung von 233 Erkrankungsmeldungen. Doctoral Dissertation, GHS-Wuppertal, Wuppertal, Federal Republic of Germany
Wolf J, Hartung M, Schroeder HG, Kleinsasser O, Compes C, Valentin H (1988) Boesartige Tumoren der Nase im Bereich der Holzwirtschaft. Empirisch-kasuistische Studie zur Belastungssituation (III). Arbeitsmed Sozialmed Praeventivmed Sonderheft 10:1–23
Wolf O (1978) Berufliche und außerberufliche Faktoren beim Kehlkopfkrebs. Z Gesamt Hyg 24:174–177
Wright WE, Bernstein L, Peters JM, Garabrant DH, Mack M (1988) Adenocarcinoma of the stomach and exposure to occupational dust. Am J Epidemiol 128:64–73
Wynder EL, Onderdonk J, Mantel N (1963) An epidemiological investigation of cancer of the bladder. Cancer 16:1388–1407
Wynder EL, Covey LS, Mabuchi K, Mushinski M (1976) Environmental factors in cancer of the larynx: a second look. Cancer 38:1591–1601
Zange J, Scholtz HJ (1963) 25 Jahre Behandlung boesartiger Geschwuelste der Nase und Nebenhoehlen in Jena und ihr Ergebnis. Z Laryngol Rhinol Otol 42:613–640
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The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author.
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Mohtashamipur, E., Norpoth, K. & Lühmann, F. Cancer epidemiology of woodworking. J Cancer Res Clin Oncol 115, 503–515 (1989). https://doi.org/10.1007/BF00391350
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DOI: https://doi.org/10.1007/BF00391350