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TNM stage, immunohistology, syntactic structure analysis and survival in patients with small cell anaplastic carcinoma of the lung

  • Original Papers
  • Clinical Oncology or Epidemiology
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Summary

TNM stage, immunostaining with various monoclonal and polyclonal antibodies, analysis of distance of neighboring cells, remission rates, and survival were analyzed in 60 patients suffering from small cell anaplastic carcinoma of the lung. The majority of patients showed advanced tumors at the time of admission to hospital (T2, T3 stage). Distant metastases prior to chemotherapy were detected in 34 patients. Partial remissions lasting 2–4 months were observed in 38 patients, and complete remission was documented in 7 patients. The remission rate was independent of cell type but dependent on the stage of the tumor. Some 30 patients showed positive staining with an antibody recognizing epitopes detectable on carcinoembryonic antigen, whereas 60% of the tumors were positive to a polyclonal neuron-specific enolase antibody. Tissue polypeptide antigen was found to stain positively in 5 cases only. Some 14 patients with negative staining against the monoclonal antibody BMA 406/14 showed prolonged survival compared to patients with positive staining (P<0.05). Patients suffering from tumors with smaller distances between neighboring cells had worse prognoses compared to patients with larger distances (P<0.01). Survival of patients was found to be indistinguishable if cohorts were grouped according to T stage, N stage, or existence of distant metastases. Ten patients who underwent surgical treatment of tumors did not show prolonged survival compared to 50 patients treated by combined chemotherapy only.

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References

  • Broder LE, Cohne MH, Selawry OS (1977) Treatment of bronchogenic carcinoma. II. Small cell. Cancer Treat Rev 4:621–260

    Google Scholar 

  • Burdon JGW, Sinclair RA, Henderson MM (1979) Small cell carcinoma of the lung. Prognosis in relation to histologic subtypes. Chest 76:302–304

    PubMed  Google Scholar 

  • Carney DN, Matthews MJ, Ihde DC, Bunn PA, Cohen MH, Makuch RW, Gazdar AF, Minna JD (1980) Influence of histologic subtype of small cell carcinoma of the lung on clinical presentation, response to therapy, and survival. J Natl Cancer Inst 65:1225–1229

    PubMed  Google Scholar 

  • Carney DN, Broder L, Edelstein M, Gazdar AF, Hansen M, Havemann K, Matthews MJ, Sorenson GD, Vindelov L (1983) Experimental studies of the biology of human small cell lung cancer. Cancer Treat Rep 67:27–35

    PubMed  Google Scholar 

  • Carney DN, Gazdar AF, Bepler G, Guccion JG, Marangos PJ, Moody TW, Zweig MH, Minna JD (1985) Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res 45:2913–2923

    PubMed  Google Scholar 

  • Cooksey JA, Bitran JD, Desser RK (1979) Small cell carcinoma of the lung: the prognostic significance of stage on survival. Eur J Cancer 15:859–865

    PubMed  Google Scholar 

  • Davis S, Wright PW, Schulman SF, Scholes D, Thorning D, Hammar S (1985) Long-term survival in small cell carcinoma of the lung: A population experience. J Clin Oncol 3:80–91

    PubMed  Google Scholar 

  • De Leij L, Poppema S, Klein Nulend J, Ter Haar A, Schwander E, Ebbens F, Postmus PE, The Hauw T (1985) Neuroendocrine differentiation antigen on human lung carcinoma and Kulchitski cells. Cancer Res 45:2192–2200

    PubMed  Google Scholar 

  • Edmonson JH, Lagakos SW, Selawry OS, Perlia CP, Bennett JM, Muggia FM, Wampler G, Brodovsky HS, Horton J, Colsky J, Mansour EG, Creech R, Stolbach L, Greenspan EM, Levitt M, Israel L, Ezdinli E, Carbone P (1976) Cyclophosphamide plus CCNU compared to cyclophosphamide alone in the treatment of small cell and adenocarcinoma of the lung. Cancer Treat Rep 60:925–932

    PubMed  Google Scholar 

  • Friese G, Gabler A, Liebig S (1978) Bronchial carcinomas and long term survival. Retrospective study of 433 patients who underwent resection. Thorax 33:228–234

    PubMed  Google Scholar 

  • Gazdar AF (1984) The pathology of endocrine tumors in the lung. In: Becker KB, Gazdar AF (eds) The endocrine lung in health and disease. Saunders WB, Philadelphia, pp 364–372

    Google Scholar 

  • Gazdar AF, Carney DN, Guccion JG, Baylin SB (1981) Small cell carcinoma of the lung: cellular origin and relationship to other pulmonary tumors. In: Greco FA, Oldham RK, Bunn PA (eds) Small cell lung cancer. Grune & Stratton, New York, pp 145–175

    Google Scholar 

  • Gazdar AF, Carney DN, Nau MM, Minna JD (1985) Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties. Cancer Res 45:2924–2930

    PubMed  Google Scholar 

  • Goodwin G, Baylin SB (1982) Relationships between neuroendocrine differentiation and sensitivity to radiation in culture line OH-1 of human small cell lung carcinoma. Cancer Res 42:1361–1367

    PubMed  Google Scholar 

  • Gould VE (1983) The endocrine lung. Lab Invest 48: 507–509

    PubMed  Google Scholar 

  • Greco FA, Einhorn LA, Richardson RL (1978) Small cell lung cancer: Progress and perspectives. Semin Oncol 3:323–335

    Google Scholar 

  • Greco FA, Oldham RK, Bunn PA (1981) Small cell carcinoma of the lung. Grune & Stratton, New York

    Google Scholar 

  • Gropp C, Luster W, Havemann K (1985) Calcitonin in lung cancer. Recent Results Cancer Res 99:79–87

    PubMed  Google Scholar 

  • Hansen HH, Dombernowsky P, Hansen M, Hirsch FR (1978) Chemotherapy of advanced small cell anaplastic carcinoma. Superiority of four-drug combination to a three-drug combination. Ann Intern Med 89:177–181

    PubMed  Google Scholar 

  • Harper PG, Souhami RL, Spiro SG, Geddes DM, Guimaraes M, Fearon F, Smyth FJ (1982) Tumor size, response rate, and prognosis in small cell carcinoma of the bronchus treated by combination chemotherapy. Cancer Treat Rep 66:463–470

    PubMed  Google Scholar 

  • Hattori S, Matsuda M, Ikegami H, Horai T, Takenaga A (1977) Small cell carcinoma of the lung: Clinical and cytomorphological studies in relation to its response to chemotherapy. Gann 68:321–331

    PubMed  Google Scholar 

  • Havemann K, Rolle R, Gropp C (1985a) Prospective multicenter study of hormone markers in small cell lung cancer. Recent Results Cancer Res 99:194–208

    PubMed  Google Scholar 

  • Havemann K, Luster W, Gropp C, Holle R (1985b) Peptide hormone production associated with small cell lung cancer. Recent Results Cancer Res 97:65–76

    PubMed  Google Scholar 

  • Heyderman E, Chapman DV, Richardson TC (1982) Biological markers in lung cancer: An immunocytochemical approach. Cancer Detect Prevent 5:427–449

    PubMed  Google Scholar 

  • Higgins GA, Shields TW, Keehn RJ (1975) The solitary pulmonary nodule. Ten-year follow-up of Veterans Administration Armed Forces cooperative study. Arch Surg 110:570–575

    PubMed  Google Scholar 

  • Hinson KFW, Miller AB, Tall R (1975) An assessment of the World Health Organization Classification of the histological typing of lung tumors applied to biopsy and resected material. Cancer 35:399–405

    PubMed  Google Scholar 

  • Ihde DC, Hansen HH (1981) Staging procedures and prognostic factors in small cell carcinoma of the lung. In: Greco A, Bunn PA, Oldham R (eds) Small cell lung cancer. Grune & Stratton, New York, pp 261–283

    Google Scholar 

  • Johnson RE, Brereton HD, Kent CH (1976) Small cell carcinoma of the lung: Attempt to remedy causes of past therapeutic failure. Lancet 2:289–291

    Article  PubMed  Google Scholar 

  • Kaplan EL, Meier P (1958) NOnparametric estimation from incomplete observations. J Am Stat Assoc 53:447–454

    Google Scholar 

  • Kayser K, Schlegel W (1982) Pattern recognition in histo-pathology: Basic considerations. Methods Inform Med 21:15–22

    Google Scholar 

  • Kayser K, Toomes H, Vollhaber HH, Burkhardt HU (1985) Tumour volume and macroscopic growth pattern of bronchogenic carcinoma. Virchows Arch [A] 405:387–397

    Google Scholar 

  • Kayser K, Kiefer B, Merkle NM, Vollhaber HH (1986) Strukturelle Bildanalyse als diagnostisches Hilfsmittel in der Histopathologie. Tum Diagn Ther 7:21–27

    Google Scholar 

  • Larsson S (1973) Pretreatment classification and staging of bronchogenic carcinoma. Scand J Thorac Cardiovasc Surg 7:44–56

    Google Scholar 

  • Livingston RB, Moore TN, Heilbrun L, Bottomley R, Lehane D, Rivkin SE, Thigpen T (1978) Small cell carcinoma of the lung: combined chemotherapy and radiation. Ann Intern Med 88:194–199

    PubMed  Google Scholar 

  • Lowenbraun S, Bartolucci A, Smalley RV, Lynn M, Krauss S, Durant JD, Southeastern Cancer Study Group (1979) The superiority of combination chemotherapy over single agent in small cell lung carcinoma. Cancer 44:406–413

    PubMed  Google Scholar 

  • Marangos PJ, Gazdar AF, carney DN (1982) Neuron specific enolase in human small cell carcinoma cultures. cancer Lett 15:67–71

    Article  PubMed  Google Scholar 

  • Matthews M, Gazdar AF (1981) Pathology of small cell carcinoma of the lung and its subtypes. a clinico-pathologic correlation. In: Livingstone RB (ed) Lung cancer 1. Martinus Nijhoff Publishers, the Hague, Boston, London, pp 283–306

    Google Scholar 

  • Maurer LH, tulloh M, weiss RB (1980) A randomized combined modality trial in small cell carcinoma of the lung. Comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy, effects of maintenance chemotherapy and prophylactic whole brain irradiation. Cancer 45:30–39

    PubMed  Google Scholar 

  • Meyer JA (1985) Effect of histologically verified TNM-stage on disease control in treated small cell carcinoma of the lung. Cancer 55:1747–1752

    PubMed  Google Scholar 

  • Müller KM, Menne R (1985) Small cell carcinoma of the lung: Pathological anatomy. Recent Results Cancer Res 97:11–24

    PubMed  Google Scholar 

  • Niederle N, Schütte J (1985) Chemotherapeutic results in small cell lung cancer. Recent Results Cancer Res 97:127–145

    PubMed  Google Scholar 

  • Nixon DW, Murphy GF, Sewell CW, Kutner M, Lynn MJ (1979) Relationship between survival and histologic type in small cell anaplastic carcinoma of the lung. Cancer 44:1045–1049

    PubMed  Google Scholar 

  • O'callaghan FJ (1975) An alternative definition for neighborhood of a point. IEEE Trans Comput 24:1121–1125

    Google Scholar 

  • Pascal RR, Mesa-Tejada R, Benett SJ, Garces A, Fenoglio CM (1977) Carcinoembryonic antigen. Arch Pathol Lab Med 101:568–571

    PubMed  Google Scholar 

  • Prewitt JMS (1979) Graphs and grammars for histology: An introduction. Proc Third Ann Symp Comp Appl Med Care, Washington

  • Reinila A, Dammert K (1974) An attempt to use the WHO typing in the histological classification of lung carcinomas. Acta Pathol Microbiol Scand 82:783–790

    Google Scholar 

  • Saksela K, Bergh J, Lehto VP, Nilsson K, Alitalo K (1985) Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer. Cancer Res 45:1823–1827

    PubMed  Google Scholar 

  • Sehested M, Hirsch FR, Osterlind K, Olsen JE (1986) Morphologic variations of small cell lung cancer. Cancer 57:804–807

    PubMed  Google Scholar 

  • Shore DF, Paneth M (1980) Survival after resection of small cell carcinoma of the bronchus. Thorax 35:819–822

    PubMed  Google Scholar 

  • Sorensen GD, Pettengill OS, Brinck-Johnson T, Cate CC, Maurer LH (1981) Hormone production by cultures of small cell carcinoma of the lung. Cancer 47:1289–1296

    PubMed  Google Scholar 

  • Souhami RL, Bradbury I, Geddes DM, Spiro SG, Harper PG, Tobias JS (1985) Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung. Cancer Res 45:2878–2882

    PubMed  Google Scholar 

  • Stanley KE (1980) Prognostic factors for survival in patients with inoperable lung cancer. J Natl Cancer Inst 65:25–32

    PubMed  Google Scholar 

  • Vincent RG, Chu TM, Fergen TB, Ostrander M (1975) Carcinoembryonic antigen in 228 patients with carcinoma of the lung. Cancer 36:2069–2076

    PubMed  Google Scholar 

  • Wachner R, wittekind C, von Kleist S (1984) Localization of CEA, β-HCG, SP1, and keratin in the tissue of lung carcinomas. An immunohistochemical study. virchows Arch [A] 402:1–9

    Google Scholar 

  • Whang-Peng J, Bunn PA, Kao-Shan CS, Carney DN, Minna JD, Gazdar AF (1982) A nonrandom chromosomal abnormality of deletion 3p (14–23) in human cell lung cancer (SCCL). Cancer Genet Cytogenet 6:119–134

    Article  PubMed  Google Scholar 

  • Wheeler RH, Nishiyama RR, Fayos JV, Bull FE (1976) Difference in response to combined modality therapy of small cell undifferentiated carcinoma of the lung according to histologic classification. Proc Am Assoc Cancer Res & ASCO 17:274

    Google Scholar 

  • World Health Organization (1981) Histological classification of lung tumors. WHO, Geneva

    Google Scholar 

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Authors and Affiliations

  1. Heidelberg-Rohrbach, Hospital for Thoracic Diseases, D-6900, Heidelberg, Federal Republic of Germany

    K. Kayser, M. Fitzer, H. Bülzebruck & P. Drings

  2. Benring-Werke, Marburg, D-3550, Marburg, Federal Republic of Germany

    K. Bosslet

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  1. K. Kayser
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  2. M. Fitzer
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  3. H. Bülzebruck
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  4. K. Bosslet
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  5. P. Drings
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Kayser, K., Fitzer, M., Bülzebruck, H. et al. TNM stage, immunohistology, syntactic structure analysis and survival in patients with small cell anaplastic carcinoma of the lung. J Cancer Res Clin Oncol 113, 473–480 (1987). https://doi.org/10.1007/BF00390042

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  • DOI: https://doi.org/10.1007/BF00390042

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