Summary
Studies of occupational cancer are particularly significant for primary prevention of cancer. Firstly, most cancers, once identified, can be prevented by reasonably simple means, without impinging on personal freedom. Secondly, the prevention of occupational cancers represents a saving of lives and the elimination of illness during the most active period of the lifespan. A third reason for investigating occupational cancers is that, in some cases, workers represent a particularly heavily exposed subgroup, and the occupational setting thus serves as a laboratory for the general environment. The protection of human health in the workplace should not depend solely on the epidemiological demonstration of existing risks; it is essential that results of predictive toxicology from long-and short-term laboratory studies also be used in the identification of possible carcinogenic risk factors.
References
Berenblum I (ed) (1984) Carcinogenesis as a biological problem. Frontiers of biology, vol 34. North Holland Publishing Co, Amsterdam
Berenblum K, Shubik P (1947) A new, quantitative, approach to the study of the stages of chemical carcinogenesis in the mouse's skin. Br J Cancer 1:383–391
Brinton LA, Blot WJ, Fraumeni J (1985) Nasal cancer in the textile and clothing industries. Br J Ind Med 42:469–474
Brown DP, Wagoner JK (1979) Mortality patterns among miners and millers occupationally exposed to asbestiform talc. In: Dement JM, Lemen R (eds) Dusts and disease. Pathotox Publishers, Park Forst South, pp 317–324
Cook JW, Hieger I, Kennaway EL, Mayneord WV (1932) The production of cancer by pure hydrocarbons. Part I Proc R Soc London Ser B III:455–484
Creech JL Jr, Johnson MN (1974) Angiosarcoma of liver in the manufacture of polyvinyl chloride. J Occup Med 16:150–151
Day NE (1985) Risk estimation models. In: Vouck VB, Butler GC, Hoel DG, Peakall DB (eds) Methods for estimating risk of chemical injury: human and non-human biota and ecosystems. John Wiley & Sons, New York, pp 381–393
Day NE, Boice JD (eds) (1983) Second cancer in relation to radiation treatment for cervical cancer. IARC scientific publications, vol 52. International Agency for Research on Cancer, Lyon, pp 138–181
Day NE, Brown CC (1980) Multistage models and primary prevention of cancer. J Natl Cancer Inst 64:977–989
Dement JM, Zumwalde RD, Gamble JF, Fellner W, De Meo MJ, Brown DP, Wagner JK (1980) Occupational exposure to tale containing asbestos. NIOSH technical report series, DHEW (NIOSH) publication no 80-115. National Institute for Occupational Safety and Health, Cincinati, OH
Doll R (1955) Mortality from lung cancer in asbestos workers. Br J Ind Med 12:81–86
Doll R (1978) An epidemiological perspective of the biology of cancer. Cancer Res 38:3573–3583
Doll R, Peto R (1976) Mortality in relation to smoking: 20 years' observation on male British doctors. Br Med J 2:1525–1536
Eriksson M, Hardell L, Berg NO, Moller T, Axelson O (1981) Softtissue sarcomas and exposure to chemical substances: a case-referent study. Br J Ind Med 38:27–33
Hardell L, Sandström A (1979) Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br J Cancer 39:11–17
Hardell L, Eriksson M, Lenner P, Lundgren E (1981) Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. Br J Cancer 43:169–176
Hemminki K, Vainio H (1984) Human exposure to potentially carcinogenic compounds. In: Berlin A, Draper M, Hemminki K, Vainio H (eds) Monitoring human exposure to carcinogenic and mutagenic agents. IARC scientific publications, vol 59. International Agency for Research on Cancer, Lyon, pp 37–45
Hoar SK, Blair A, Holmes FF, Boysen CD, Robel RJ, Hoover R, Fraumeni JF (1986) Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. J Am Med Assoc 256:1141–1147
Hooper K, Gold LS (1986) Ranking the carcinogenic hazards of occupational exposures: exposure-potency index (EPI) values for nine volatile industrial chemicals. In: Sorsa M, Norppa H (eds) Monitoring of occupational genotoxic chemicals. Alan R. Liss, New York, pp 217–228
Hueper WC, Wiley FH, Wolfe HD (1938) Experimental production of bladder tumors in dogs by administration of beta-naphthylamine. J Ind Hyg Toxicol 20:46–84
IARC (1972) IARC monographs on the evaluation of carcinogenic risk of chemicals to man, vol 1, some inorganic substances, chlorinated hydrocarbons, aromatic amines, N-nitroso compounds, and natural products. International Agency for Research on Cancer, Lyon
IARC (1974) IARC monographs on the evaluation of carcinogenic risk of chemicals to man, vol 4, some aromatic amines, hydrazine and related substances, N-nitroso compounds and miscellaneous alkylating agents. International Agency for Research on Cancer, Lyon
IARC (1976) IARC monographs on the evaluation of carcinogenic risk of chemicals to man, vol 11, cadmium, nickel, some epoxides, miscellaneous industrial chemicals and general considerations on volatile anaesthetics. International Agency for Research on Cancer, Lyon
IARC (1977) IARC monographs on the evaluation of carcinogenic risk of chemicals to man, vol 14, asbestos. International Agency for Research on Cancer, Lyon
IARC (1979) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 19, some monomers, plastics and synthetic elastomers, and acrolei. International Agency for Research on Cancer, Lyon
IARC (1980a) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 23, some metals and metallic compounds. International Agency for Research on Cancer, Lyon
IARC (1980b) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 25, wood, leather and some associated industries. International Agency for Research on Cancer, Lyon
IARC (1982b) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 29, some industrial chemicals and dyestuffs. International Agency for Research on Cancer, Lyon
IARC (1982c) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 28, the rubber industry. International Agency for Research on Cancer, Lyon
IARC (1983) Approaches to classifying chemical carcinogens according to mechanism of action (IARC internal technical report no 83/001). International Agency for Research on Cancer, Lyon
IARC (1984a) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 33, polynuclear aromatic compounds, part 2, carbon blacks, mineral oils and some nitroarenes. International Agency for Research on Cancer, Lyon
IARC (1984b) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans vol 34, polynuclear aromatic compounds, part 3, industrial exposures in aluminium production, coal gasification, coke production, and iron and steel founding. International Agency for Research on Cancer, Lyon
IARC (1985) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 35, polynuclear aromatic compounds, part 4, bitumens, coal-tars and derived products, shale-oils and soots. International Agency for Research on Cancer, Lyon
IARC (1986) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 41, some halogenated hydrocarbons and pesticide exposures. International Agency for Research on Cancer, Lyon
IARC (1987) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, suppl 7, chemicals, occupational exposures and cultural habits associated with cancer in humans, vols 1–42. International Agency for Research on Cancer, Lyon
International Labour office (1921) Cancer of the bladder among workers in aniline factories. Studies and reports series no 1. Geneva, pp 1–26
Ishinishi I, Yamamoto A, Hisanaga A, Inamasu T (1983) Tumorigenicity of arsenic trioxide to the lung in Syrian golden hamsters by intermittent instillations. Cancer Lett 21:141–147
Kinlen LJ (1982) Immunosuppressive therapy and cancer. Cancer Surv 1:565–583
Kleinfeld M, Messite J, Kooyman O, Zaki MH (1967) Mortality among talc miners and millers in New York state. Arch Environ Health 14:663–667
Kleinfeld M, Messite J, Zaki MH (1974) Mortality experiences among talc workers: a follow-up study. J Occup Med 16:345–349
MacLure KM, MacMahon B (1980) An epidemiologic perspective of environmental carcinogenesis. Epidemiol Rev 2:19–48
Merletti F, Heseltine E, Saracci R, Simonato L, Vainio H, Wilbourn J (1984) Target organs for carcinogenicity of chemicals and industrial exposures in humans. Cancer Res 44:2244–2250
Mohtashamipur E, Norpoth K, Hallerberg B (1986) A fraction of beech wood mutagenic in the Salmonella/mammalian microsome assay. Int Arch Occup Environ Health 58:227–234
Ng TP (1986) A case-referent study of cancer of the nasal cavity and sinuses in Hong Kong. Int J Epidemiol 15:171–175
Nicholson WJ, Perkel G, Selikoff IJ (1982) Occupational exposure to asbestos: population at risk and projected mortality-1980-2030. Am J Ind Med 3:259–311
Nutt A (1983) Rubber work and health-past, present, and perspective. Scand J Work Environ Health 9:(Suppl 2)49–57
office of Science and Technology Policy (1985) Chemical carcinogens; a review of the science and its associated principles. Fed Reg, March 14:10371–10442
Pershagen G (1985) Lung cancer mortality among men living near an arsenic emitting smelter. Am J Epidemiol 122:684–694
Pershagen G, Bjökland N-E (1985) On the pulmonary tumorigenicity of arsenic trisulfide and calcium arsenate in hamsters. Cancer Lett 27:99–104
Pershagen G, Nordberg G, Björkland N-E (1984) Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo(a)pyrene by the pulmonary route. Environ Res 34:227–241
Peto J (1979) Dose response relationships for asbestos related disease: implications for hygiene standards. Part III. Mortality. Ann NY Acad Sci 330:195–201
Peto J, Seidman H, Selikoff IJ (1982) Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. Br J Cancer 45:124–135
Pott P (1775) Chirurgical observations relative to the cataract, the polypus of the nose, the cancer of the scrotum, the different kinds of ruptures, and the mortification of the toes and feet. Hawes, Clarke and Collins, London, pp 63–65
Rehn L (1895) Blasengeschwülste bei Fuchsin-Arbeitern. Arch klin Chir 50:588–600
Scherer K, Emmelot P (1975) Kinetics of induction and growth of precancerous liver cell foci and liver tumour formation by diethylnitrosamine in the rat. Eur J Cancer 11:689–695
Schmähl D, Kaldor J (eds) Carcinogenicity of alkylating cytostatic drugs. IARC scientific publications, vol 78. International Agency for Research on Cancer, Lyon (in press)
Selevan SG, Dement JM, Wagoner JK, Froines JR (1979) Mortality patterns among miners and millers of non-asbestiform talc: preliminary report. In: Lemen R, Dement JM (eds) Dusts and disease. Pathotox Publishers, Park Forest South, IL, pp 379–388
Selikoff IJ, Hammond ED (1975) Multiple risk factors in environmental cancer. In: Fraumeni JF Jr (ed) Persons at high risk of cancer. Academic Press, New York, pp 467–483
Selikoff IJ, Hammond EC, Seidman H (1979) Mortality experience of insulation workers in the United States and Canada 1943–1976. Ann NY Acad Sci 330:91–116
Smith AH, Fisher DO, Pearce NE, Teague CA (1982) Do agricultural chemicals cause soft tissue sarcoma? Initial findings of a case-control study in New Zealand. Community Health Stud 6:114–119
Smith AH, Pearce NE, Fisher DO, Giles HJ, Teague CA, Howard JK (1984) Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. J Natl Cancer Inst 73:1111–1117
Sorsa M, Hemminki K, Vainio H (1985) Occupational exposure to anticancer drugs-potential and real hazards. Mutat Res 154:135–149
Spiegelhalder B, Preussmann R (1983) Occupational nitrosamine exposure. 1. Rubber and tyre industry. Carcinogenesis 4:1137–1152
Tomatis L (1977) The value of long-term testing for the implementation of primary prevention. In: Hiatt HH, Watson JD, Winsten JA (eds) Origins of human cancer, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 1339–1357
Vainio H, Saracci R (1986) Carcinogenicity of selected vinyl compounds, some aldehydes, haloethyl nitrosoureas and furocoumarins: an overview. In: Singer B, Bartsch H (eds) The role of cyclic nucleic acid adducts in carcinogenesis and mutagenesis. IARC scientific publications, vol 70. International Agency for Research on Cancer, Lyon, pp 15–29
Vainio H, Tomatis L (1986) Exposure to carcinogens: an overview of scientific and regulatory aspects. Appl Ind Hyg 1:42–48
Vainio H, Hemminki K, Wilbourn J (1985) Data on the carcinogenicity of chemicals in the IARC Monographs programme. Carcinogenesis 6:1653–1665
Viola PL, Bigotti A, Caputo A (1971) Oncogenic response of rat skin, lungs, and bones to vinyl chloride. Cancer Res 31:516–522
Wilbourn J, Haroun L, Heseltine E, Kaldor J, Montesano R, Partensky C, Vainio H (1987) Response of experimental animals to human carcinogens: an analysis of the IARC Monographs programme. Carcinogenesis (in press)
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The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author
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Vainio, H. Occupational cancer prevention. J Cancer Res Clin Oncol 113, 403–412 (1987). https://doi.org/10.1007/BF00390033
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DOI: https://doi.org/10.1007/BF00390033