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Cytogenetics of Malignant Lymphomas

Studies utilising a giemsa-banding technique

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Summary

The chromosomes from the tumours of 10 cases of Malignant Lymphoma have been analysed in detail with the aid of recently developed chromosome banding techniques.

In each case cells with abnormal karyotypes were found which contained chromosme structural changes. Several of these changes were common to two or more of the tumours. The breakpoints in the altered chromosomes were almost invariably in the light-band or centromeric regions.

Zusammenfassung

Die Chromosomen der Tumoren von 10 Fällen mit malignem Melanom wurden im einzelnen mit Hilfe der kürzlich entwickelten Techniken zur Untersuchung der Chromosomen-Bandmuster analysiert.

In allen Fällen fanden sich Zellen mit abnormen Karyotypen, die strukturelle Chromosomenveränderungen enthielten. Mehreren dieser Veränderungen waren zwei oder mehr Tumoren gemeinsam. Die Bruchstellen der veränderten Chromosomen waren fast assuchließlich in den hellen Zwischenbanden oder in den Zentromer-Regionen gelegen.

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Authors and Affiliations

  1. Department of Cytogenetics and Immunology, Division of Medicine, Royal Marsden Hospital, London

    B. R. Reeves

  2. Institute of Cancer Research, London

    B. R. Reeves

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  1. B. R. Reeves
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Reeves, B.R. Cytogenetics of Malignant Lymphomas. Humangenetik 20, 231–250 (1973). https://doi.org/10.1007/BF00385735

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  • DOI: https://doi.org/10.1007/BF00385735

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