Skip to main content
SpringerLink
Log in

Genetic analysis of the wing vein pattern of Drosophila

  • Published:
Roux's archives of developmental biology Aims and scope Submit manuscript

Summary

Of the many mutations known to affect the wing vein pattern we have selected the most extreme in 29 genes for study. Their phenotype can be classified in two major classes: lack-of-veins and excess-of-veins, and in several internally coherent groups. The study of multiple mutant combinations, within groups and between groups, reveals several genetic operations at work in the generation of the vein pattern. The finding that some of these mutations also affect cell proliferation in characteristic ways has prompted a generative model of wing morphogenetic and pattern formation based on cell behaviour properties defined by the corresponding wild-type genes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Akam M (1987) The molecular basis for metameric pattern in Drosophila embryo. Development 101:1–22

    Google Scholar 

  • Anderson DT (1972) The development of hemimetabolous insects. In: Counce SJ, Waddington CH (eds) Developmental systems: insects, vol 1. Academic Press, London New York, pp 95–163

    Google Scholar 

  • Bryant P (1970) Cell lineage relationships in the imaginai wing disc of Drosophila melanogaster. Dev Biol 22:398–411

    Google Scholar 

  • Busson D, Limbourg-Bouchon B, Mariol MC, Preat T, Laumour-Isnard C (1988) Genetic analysis of viable and lethal fused mutants of Drosophila melanogaster. Roux's Arch Dev Biol 197:221–230

    Google Scholar 

  • Canal I (1988) Análisis genético del metamerismo en el sistema nervioso embrionario de Drosophila melanogaster. Ph.D. Dissertation. Universidad Autónoma de Madrid, Spain

    Google Scholar 

  • de la Concha A, Dietrich U, Weigel D, Campos-Ortega JA (1988) Functional interactions of neurogenic genes of Drosophila melanogaster. Genetics 118:499–508

    Google Scholar 

  • Craymer L (1980) Ach: Achaetous. Drosophila Information Service 55:197

    Google Scholar 

  • Fausto-Sterling A (1978) Pattern formation in the wing veins of the fused mutant (Drosophila melanogaster). Dev Biol 63:358–369

    Google Scholar 

  • Ferris GF (1965) External morphology of the adult. In: Demerec MW (ed) Biology of Drosophila. Hafner, London New York, pp 368–418

    Google Scholar 

  • García Alonso L, García-Bellido A (1986) Genetic analysis of Hairy-wing mutations. Roux's Arch Dev Biol 195:259–264

    Google Scholar 

  • García Alonso L, García-Bellido A (1988) Extramacrochaete, a trans-acting gene of the achaete-scute complex of Drosophila involved in cell communication. Roux's Arch Dev Biol 197:328–338

    Google Scholar 

  • García-Bellido A (1977) Inductive mechanisms in the process of the wing vein formation in Drosophila. Roux's Arch Dev Biol 182:93–106

    Google Scholar 

  • García-Bellido A (1981) From the gene to the pattern: chaeta differentiation. In: Lloyd CW, Rees DA (eds) Cellular controls in differentiation. Academic Press, New York, pp 281–304

    Google Scholar 

  • García-Bellido A, Merriam JR (1971a) Parameters of the wing imaginai disc development of Drosophila melanogaster. Dev Biol 24:61–87

    PubMed  Google Scholar 

  • García-Bellido A, Merriam JR (1971b) Genetic analysis of cell heredity in imaginal discs of Drosophila melanogaster. Proc Natl Acad Sci USA 68:2222–2226

    Google Scholar 

  • Garcá-Bellido A, Santamaría P (1972) Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster. Genetics 72:87–104

    Google Scholar 

  • Garcá-Bellido A, Santamaría P (1978) Developmental analysis of the achaete-scute system of Drosophila melanogaster. Genetics 88:469–486

    Google Scholar 

  • Ghysen A, Dambly-Chaudiere C (1988) From DNA to form: the achaete-scute complex. Genes Dev 2:495–501

    PubMed  Google Scholar 

  • Hadorn E (1948) Gene action in growth and differentiation of lethal mutant of Drosophila. Symp Soc Exp Biol 2:177–195

    Google Scholar 

  • Ingham PW (1988) The molecular genetics of embryonic pattern formation in Drosophila. Nature 335:25–34

    Google Scholar 

  • Irish VF, Gelbart WM (1987) The decapentaplegic gene is required for dorsal-ventral pattering of the Drosophila embryo. Genes Dev 1:868–879

    Google Scholar 

  • Jürgen G, Wieschaus E, Nüsslein-Volhard C, Kluding H (1984) Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the third chromosome. Roux's Arch Dev Biol 193:283–295

    Google Scholar 

  • Lewis EB (1951) Psedoallelism and gene evolution. Cold Spring Harbor Symp Quant Biol 16:159–174

    Google Scholar 

  • Lewis EB, Bacher F (1968) Method of feeding ethyl methanesulphonate (EMS) to Drosophila males. Drosophila Information Service 43:193

    Google Scholar 

  • Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Inst Wash Publ 627

  • Martinez-Arias A (1985) The development of fused-embryos of Drosophila melanogaster. J Embryol Exp Morphol 87:99–114

    Google Scholar 

  • Mayer U, Nüsslein-Volhard C (1988) A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev 2:1496–1511

    Google Scholar 

  • Nüsslein-Volhard C, Wieschaus E (1980) Segmentation in Drosophila: mutations affecting segment number and polarity. Nature 287:795–801

    Google Scholar 

  • Nüsslein-Volhard C, Wieschaus E, Kluding H (1984) Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch Dev Biol 193:267–282

    Google Scholar 

  • Orenic T, Chidsey J, Holmgren R (1987) Cell and cubitus interruptus Dominant: two segment polarity genes on the fourth chromosome in Drosophila. Dev Biol 124:50–56

    Google Scholar 

  • Portin P (1975) Allelic negative complementation at the Abruptex locus of Drosophila melanogaster. Genetics 116:433–445

    Google Scholar 

  • Preiss A, Hartley DA, Artavanis-Tsakonas S (1988) The molecular genetic of Enhancer of split, a gene required for embryonic neural development in Drosophila. EMBO J 7:3917–3927

    Google Scholar 

  • Puro J (1982a) Drosophila Information Service 58:205

    Google Scholar 

  • Puro J (1982b) Drosophila Information Service 58:206

    Google Scholar 

  • Ruiz-Gomez M, Modolell J (1987) Deletion analysis of the achaetescute locus of Drosophila melanogaster. Genes Dev 1:1238–1246

    Google Scholar 

  • Schubiger M, Palka I (1987) Changing spatial patterns of DNA replication in the developing wing of Drosophila. Dev Biol 123:145–153

    Google Scholar 

  • Segal D, Gelbart WM (1985) shortvein, a new component of the decapentaplegic gene complex in Drosophila melanogaster. Genetics 109:119–143

    Google Scholar 

  • Snodgrass RE (1936) The principles of insect morphology. McGrawn-Hill, New York

    Google Scholar 

  • Spencer FA, Hoffmann FM, Gelbart WM (1982) Decapentaplegic: a gene complex affecting morphogenesis in Drosophila melanogaster. Cell 28:451–461

    Google Scholar 

  • Stern C (1954) Two or three bristles. Am Sci 42:213–247

    Google Scholar 

  • Szidonya J, Reuter G (1988) Cytogenetic analysis of the echinoid (ed), dumpy (dp) and clot (cl) region in Drosophila melanogaster. Genet Res 51:197–208

    Google Scholar 

  • Vässin H, Campos-Ortega JA (1987) Genetic analysis of Delta, a neurogenic gene of Drosophila melanogaster. Genetics 116:433–445

    Google Scholar 

  • Vässin H, Vielmetter J, Campos-Ortega JA (1985) Genetic interactions in early neurogenesis of Drosophila melanogaster. J Neurogenet 2:291–308

    Google Scholar 

  • Waddington CH (1940) The genetic control of wing development in Drosophila. J Genet 41:75–139

    Google Scholar 

  • Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S (1985) Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43:567–581

    Google Scholar 

  • Wieschaus E, Nüsslein-Volhard C (1986) Looking at embryos. In: Roberts DB (ed) Drosophila, a practical approach. IRL Press, Oxford Washington, pp 199–228

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro de Biología Molecular, C.S.I.C., Universidad Autónoma de Madrid, E-28049, Madrid, Spain

    F. J. Diaz-Benjumea & A. García-Bellido

Authors
  1. F. J. Diaz-Benjumea
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. García-Bellido
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Diaz-Benjumea, F.J., García-Bellido, A. Genetic analysis of the wing vein pattern of Drosophila . Roux's Arch Dev Biol 198, 336–354 (1990). https://doi.org/10.1007/BF00383772

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00383772

Key words

Search

Navigation