Skip to main content
SpringerLink
Log in

Disruption of spermatogenesis in Fasciola hepatica by some anthelmintics

  • Published:
Zeitschrift für Parasitenkunde Aims and scope Submit manuscript

Summary

Eight-weeks old F. hepatica were recovered from rabbits and rats that had been treated with known fasciolicides and anthelmintics between 4 and 40 h previously. Examination of the surviving flukes showed that spermatogenesis was significantly disrupted by most of the fasciolicides but by none of the other anthelmintics. It is suggested that disruption of spermatogenesis is particularly associated with compounds showing activity against mature F. hepatica.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Baukema, J., Dill, W. A., Glazko, A. J.: The metabolism and physiological disposition of Tremerad in sheep. American Chemical Society. 154th meeting, abstracts of papers, Sec. P, No. 46 (1967)

  • Boray, J. C., Roseby, F. B.: The effect of the route of administration on the efficiency of Clioxanide against immature Fasciola hepatica in sheep. Aust. vet. J. 45, 363–365 (1969)

    PubMed  Google Scholar 

  • Clegg, J. A.: PhD thesis, University of London (1957)

  • Corbett, J. R., Goose, J.: A possible biochemical mode of action of the fasciolicides nitroxynil, hexachlorophene and oxyclozanide. Pesticide Sci. 2, 119–121 (1971)

    Google Scholar 

  • Dawes, B.: Experimental fascioliasis: some effects on Fasciola hepatica of treatment of rat hosts with bithionol (‘Actamer’). Helminthologia (Bratisl.) 7, 297–306 (1966)

    Google Scholar 

  • Dawes, B.: Further evidence on the effect of bithionol (‘Actamer’) on Fasciola hepatica. Wiad. Parazyt. 14, 575–577 (1968)

    Google Scholar 

  • Grant, M. S., Jaggers, S. E.: Studies on emetine as an ‘acute’ fasciolicide. Res. Vet. Sci. 10, 197–202 (1969)

    PubMed  Google Scholar 

  • Harfenist, M.: Diamphenethide—a new fasciolicide active against immature parasites. Pesticide Sci. 4, 871–882 (1973)

    Google Scholar 

  • Miert, A. S. J. P. A. M., Groeneveld, H. W.: Anthelmintics used for the treatment of fascioliasis as uncouplers of oxidative phosphorylation in warm blooded animals. Europ. J. Pharmacol. 8, 385–388 (1969)

    Google Scholar 

  • Stammers, B. M.: The effects of rafoxanide and nitroxynil on the survival, growth and morphology of Fasciola hepatica in rabbits. Z. Parasitenk. 46, 153–161 (1975)

    Google Scholar 

  • Tewari, H. C.: Comparative efficiency of hexachloroethane and clioxanide against Fasciola hepatica in the rat. Aust. vet. J. 44, 401–402 (1968)

    PubMed  Google Scholar 

  • Yorke, R. E., Turton, J. A.: Effects of fasciolicidal and anti-cestode agents on the respiration of isolated Hymenolepsis diminuta mitochondria. Z. Parasitenk. 45, 1–10 (1974)

    Google Scholar 

Download references

Author information

Author notes

  1. B. M. Stammers

    Present address: Technicon Instruments Co., Ltd., Basingstoke, Hampshire, England

Authors and Affiliations

  1. Veterinary Research Division, May & Baker Ltd, Ongar

    B. M. Stammers

Authors
  1. B. M. Stammers
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work forms part of a thesis approved by the University of London for the degree of Doctor of Philosophy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stammers, B.M. Disruption of spermatogenesis in Fasciola hepatica by some anthelmintics. Z. F. Parasitenkunde 47, 145–150 (1975). https://doi.org/10.1007/BF00382637

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00382637

Search

Navigation