Summary
We describe a 4.5 kilobase transposon. Tn4001, which mediates resistance to gentamicin, tobramycin and kanamycin in Staphylococcus aureus. Originally detected in plasmid pSK1, Tn4001 was shown to undergo rec-independent transposition to the chromosome from this plasmid and from an inserted derivative of the plasmid pII147. Heteroduplexes between plasmids with and without Tn4001 demonstrated a characteristic stem and loop structure with inverted repeats of approx. 1.3 kilobases.
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Communicated by W. Arber
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Lyon, B.R., May, J.W. & Skurray, R.A. Tn4001: A gentamicin and kanamycin resistance transposon in Staphylococcus aureus . Molec. Gen. Genet. 193, 554–556 (1984). https://doi.org/10.1007/BF00382099
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DOI: https://doi.org/10.1007/BF00382099