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Biomonitoring of industrial solvent exposures in workers' alveolar air

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Summary

Ten different solvents, viz., toluene, styrene, methylethyl ketone, acetone, dimethylformamide, cyclohexane, n-hexane, methylcyclopentane, 2-methylpentane, and 3-methylpentane were determined in environmental air and in the alveolar air of workers during the work shift.

As regards all ten solvents studied, alveolar concentration (Ca) and the difference between environmental concentration (CO and alveolar concentration (Ci - Ca), were correlated with environmental concentration.

According to the slopes of the regression lines, the ratio between alveolar and environmental concentration (Ca/Ci) and the alveolar retention ((Ci - Ca)/Ci) in the case of all ten solvents studied were complementary, i.e., their sum was equal to unity. The solvents with high solubility in blood, i.e., toluene, styrene, methylethyl ketone, acetone, and dimethylformamide showed a Ca/Ci ratio lower than 0.5 and the solvents with low solubility, i.e., cyclohexane, hexane, and their isomers showed a Ca/Ci ratio higher than 0.5. According to the findings which prove that the alveolar concentration of all solvents studied during the work shift is a function of variations in the environmental concentrations it seems reasonable to suggest the use of alveolar tests for monitoring environmental exposure to solvents during the work shift.

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References

  1. Astrand I, Erhner-Samuel H, Kilbom A, Ovrum P (1972) Toluene exposure. I. Concentration in alveolar air and blood at rest and during exercise. Work Environ Health 9:119–130

    Google Scholar 

  2. Astrand I, Kilbom A, Ovrum P, Wahlberg I, Vesterberg O (1974) Exposure to styrene. I. Concentration in alveolar air and blood at rest and during exercise and metabolism. Work Environ Health 11:69–85

    PubMed  Google Scholar 

  3. Astrand I (1975) Uptake of solvents in the blood and tissue of man. A review. Scand J Work Environ Health 1:199–218

    PubMed  Google Scholar 

  4. Astrand I, Ovrum P (1976) Exposure to trichloroethylene. I. Uptake and distribution in man. Scand J Work Environ Health 4:199–211

    Google Scholar 

  5. Astrand I, Ovrum P, Lindquist T, Hultengren M (1976) Exposure to buthyl alcohol. Uptake and distribution in man. Scand J Work Environ Health 3:165–175

    Google Scholar 

  6. Astrand I, Engstrom J, Ovrum P (1978) Exposure to xylene and ethylbenzene. I. Uptake distribution and elimination in man. Scand J Work Environ Health 4:185–194

    PubMed  Google Scholar 

  7. Brugnone F, Perbellini L, Grigolini L, Apostoli P (1978) Solvent exposure in a shoe upper factory. I. n-Hexane and acetone concentration in alveolar and environmental air and in blood. Int Arch Occup Environ Health 42:51–62

    PubMed  Google Scholar 

  8. Brugnone F, Perbellini L, Grigolini L, Apostoli P (1979) Solvent exposure in a shoe upper factory. II. Methylcyclopentane, 2-methylpentane, and 3-methylpentane concentration in alveolar and in environmental air and in blood. Int Arch Occup Environ Health 42:355–363

    PubMed  Google Scholar 

  9. Brugnone F, Perbellini L, Gaffuri E (1980) N-N-Dimethylformamide concentration in environmental and alveolar air in an artificial leather factory. Br J Ind Med 37:185–188

    PubMed  Google Scholar 

  10. Cander L, Forster RE (1959) Determination of pulmonary parenchymal tissue volume and pulmonary capillary blood flow in man. J Appl Physiol 14:541–551

    Google Scholar 

  11. Dalhaman T, Edfors ML, Rylanders R (1968) Retention of cigarette smoke components in human lungs. Arch Environ Health 76:746–748

    Google Scholar 

  12. DiVincenzo GD, Yanno FJ, Astill BD (1973) Exposure of man and dog to low concentration of acetone vapor. Am Ind Hyg Assoc J 34:329–336

    PubMed  Google Scholar 

  13. Eger EI (1974) Anesthetic uptake and action. Williams and Wilkins, Baltimore

    Google Scholar 

  14. Fernandez JG, Caperos JR (1977) Exposition au styrene. I. Etude de l'absorption et de l'excretion pulmonaires sur des sujets humains. Int Arch Occup Environ Health 40:1–12

    PubMed  Google Scholar 

  15. Humbert BE, Fernandez JG (1977) Exposition au l,1,1-trichloréthane. Contribution à l'étude de l'absorption, de l'excretion, et du métabolisme sur des sujets humains. Arch Mal Prof 38:415–425

    Google Scholar 

  16. Kimmerle G, Eben A (1975) Metabolism studies of N-N-dimethylformamide. II. Studies in persons. Int Arch Arbeitsmed 34:127–136

    PubMed  Google Scholar 

  17. Monster AC, Boersma G, Duba WC (1976) Pharmacokinetics of trichloroethylene in volunteers. Influence of workload and exposure concentration. Int Arch Occup Environ Health 38:87–102

    PubMed  Google Scholar 

  18. Monster AC, Boersma G, Steenweg H (1979a) Kinetics of 1,1,1-trichloroethane in volunteers. Influence of exposure concentration and work load. Int Arch Occup Environ Health 42:293–302

    PubMed  Google Scholar 

  19. Monster AC, Boersma G, Steenweg H (1979 b) Kinetics of tetrachloroethylene in volunteers. Influence of exposure concentration and work load. Int Arch Occup Environ Health 42:303–310

    Google Scholar 

  20. Morgan A, Black A, Belcher DR (1970) The excretion in breath of some aliphatic halogenated hydrocarbons following administration by inhalation. Ann Occup Hyg 13:219–233

    PubMed  Google Scholar 

  21. Morgan A, Black A, Belcher DR (1972) Studies on the absorption of halogenated hydrocarbons and their excretion in breath using 38 Cl tracer techniques. Ann Occup Hyg 15:273–282

    PubMed  Google Scholar 

  22. Nomiyama K, Nomiyama H (1974) Respiratory retention, uptake, and excretion of organic solvents in men. Int Arch Arbeitsmed 32:75–83

    PubMed  Google Scholar 

  23. Perbellini L, Brugnone F (1980) Lung uptake and metabolism of cyclohexane in shoe factory workers. Int Arch Occup Environ Health 45:261–269

    PubMed  Google Scholar 

  24. Riihimäki V, Pfaffli P, Savolainen K, Pekari K (1979) Kinetics of m-xylene in men. Scand J Work Environ Health 5:217–231

    Google Scholar 

  25. Rommelt H, Dirnagl K (1977) Pulmonale Resorption von sechs Kohlenwasserstoffen. Münch Med Wochenschr 119:367–368

    Google Scholar 

  26. Sato A, Nakajima T, Fujiwara Y, Hirosawa K (1974) Pharmacokinetics of benzene and toluene. Int Arch Arbeitsmed 33:169–182

    PubMed  Google Scholar 

  27. Sato A, Nakamjima T (1979 a) A structure-activity relationship of some chlorinated hydrocarbons. Arch Environ Health 34:69–75

    PubMed  Google Scholar 

  28. Sato A, Nakajima T (1979b) Partition coefficients of some aromatic hydrocarbons and ketones in water, blood, and oil. Br J Ind Med 36:231–234

    PubMed  Google Scholar 

  29. Sedevic V, Flek J (1976) The absorption, metabolism, and excretion of xylene in man. Int Arch Occup Environ Health 37:205–217

    PubMed  Google Scholar 

  30. Stewart RD, Hake CL, Wu A (1976) Use of breath analysis to monitor methylene chloride exposure. Scand J Work Environ Health 2:57–70

    PubMed  Google Scholar 

  31. Tada O, Nakaaki K, Fukabori S (1972) Experimental study on acetone and methylethyl ketone concentration in urine and expired air exposure to those vapor. Rodo Kagaky 48:305–310

    Google Scholar 

  32. Veulemans H, Masschelein R (1978) Experimental human exposure to toluene. I. Factors influencing the individual respiratory uptake and elimination. Int Arch Occup Environ Health 42:91–103

    PubMed  Google Scholar 

  33. Zielhuis R (1978) Biological monitoring. Guest lecture given at the 26th Nordic Symposium on Industrial Hygiene, Helsinki, October 1977. Scand J Work Environ Health 4:1–18

    Google Scholar 

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Authors and Affiliations

  1. Policlinico Borgo Roma, Institute of Occupational Medicine, University of Padua-Verona, I-37100, Verona, Italy

    F. Brugnone, L. Perbellini, E. Gaffuri & P. Apostoli

Authors
  1. F. Brugnone
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  2. L. Perbellini
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  3. E. Gaffuri
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  4. P. Apostoli
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Brugnone, F., Perbellini, L., Gaffuri, E. et al. Biomonitoring of industrial solvent exposures in workers' alveolar air. Int. Arch Occup Environ Heath 47, 245–261 (1980). https://doi.org/10.1007/BF00381682

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  • DOI: https://doi.org/10.1007/BF00381682

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