Summary
Lung specimens from 39 nickel refinery workers autopsied during the period from 1978 to 1984 were analyzed for nickel. Fifteen of the workers were employed in the Roasting and Smelting Department, where exposure to nickel was predominantly in the form of nickel-copper oxides, Ni3S2 and metallic dust. The remaining 24 men worked in the Electrolysis Department. Exposure in this group was considered to be mostly to the water-soluble compounds, NiSO4 and NiCl2, but also to a lesser degree to water-insoluble nickel compounds such as nickel-copper oxides and sulphides. The arithmetic mean ± SD for nickel concentration in lung tissues expressed in μgg−1 dry wt for the 39 workers was 150 ± 280. In the workers employed in the Roasting and Smelting Department, the average nickel concentration was 330 ± 380; for those who worked in the Electrolysis Department it was 34 ± 48. Lung tissue from 16 autopsied persons not connected with the refinery had an average nickel concentration of 0.76 ± 0.39. Statistical analysis based on log-normal distributions of the measured nickel concentrations allowed three major conclusions to be formulated: (1) nickel refinery workers exhibit elevated nickel levels in lung tissues at autopsy; (2) workers of the Electrolysis Department and the Roasting Smelting Department constitute distinct groups with respect to the accumulation of nickel in lung tissue; (3) workers who were diagnosed to have lung cancer had the same lung nickel concentrations at autopsy as those who died of other causes.
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References
Abraham JL, Barton RT, Høgetveit AC, Andersen I, Smith G (1980) Microanalysis of inorganic particles in situ in the lungs of Norwegian nickel refinery workers. In: Brown SS, Sunderman FW Jr (eds) Nickel toxicology. Academic Press, New York, pp 155–158
Andersen I, Høgetveit AC, Barton RT, Glad WR (1980) Rates of solubilization of nickel compounds in aqueous solutions and biological fluids. In: Nickel toxicology. Academic Press, New York, pp 77–80
Boysen M, Solberg LA, Andersen I, Høgeveit AC, Torjussen W (1982) Nasal histology and nickel concentrations in plasma and urine after improvements in the work environment at a refinery in Norway. Scand J Work Environ Health 8:283–289
Doll R (1984) Nickel exposure: a human health hazard. In: Sunderman FW, Jr (ed-in-chief) Nickel in the human environment, IARC Scientific Publications, No. 53. Oxford University Press, Oxford, pp 3–21
Kaldor J, Peto J, Easton D, Doll R, Herman C, Morgan L (1986) Models for respiratory cancer in nickel refinery workers. JNCI 77:841–848
Kjuus H, Skjaerven R, Langård S, Lien JT, Aamodt T (1986a) A case-referent study of lung cancer, occupational exposures and smoking. I. Comparison of title-based and exposure-based occupational information. Scand J Work Environ Health 12:193–202
Kjuus H, Langard S, Skjaerven R (1986b) A case-referent study of lung cancer, occupational exposures and smoking. III. Etiologic fraction of occupational exposures. Scand J Work Environ Health 12:210–215
Kollmeier H, Witting C, Seemann J, Wittig P, Rothe R (1985) Increased chromium and nickel content in lung tissue. J Cancer Res Clin Oncol 110:173–176
Kreyberg L (1978) Lung cancer in workers in a nickel refinery. Br J Ind Med 35:109–116
Løken Aa C (1950) Lungecarcinom hos nikkelarbeidere. Tidsskr Nor Laegeforen 70:376–380
Magnus K, Andersen Aa, Høgetveit AC (1982) Cancer of respiratory organs among workers at a nickel refinery in Norway. Int J Cancer 30:681–685
Mastromatteo E (1986) Nickel. Am Ind Hyg Assoc J 47:589–601
Nieboer E, Tom RT, Sanford WE (1988) Nickel metabolism in man and animals. In: Sigel H (ed) Nickel and its role in biology, Vol 23, Metal ions in biological systems. Marcel Dekker, New York, pp 359–402
Pedersen E, Høgetveit AC, Andersen Aa (1973) Cancer of respiratory organs among workers at a nickel refinery in Norway. Int J Cancer 12:32–41
Raithel HJ, Ebner G, Schaller KH, Schellmann B, Valentin H (1987) Problems establishing norm values for nickel and chromium concentrations in human pulmonary tissue. Am J Ind Med 12:55–70
Raithel HJ, Schaller KH, Reith A, Svenes KB, Valentin H (1988) Investigation on the quantitative determination of nickel and chromium in human lung tissue. Int Arch Occup Environ Health 60:55–66
Rezuke WN, Knight JA, Sunderman FW Jr (1987) Reference values for nickel concentrations in human tissues and bile. Am J Ind Med 11:419–426
Roberts RS, Julian JA, Muir DCF, Shannon HS (1984) Cancer mortality associated with the high-temperature oxidation of nickel subsulfide. In: Sunderman FW JR (ed-in-chief) Nickel in the human environment, IARC Scientific Publications No. 53. Oxford University Press, Oxford, pp 23–35
Roberts RS, Julian JA, Muir DCF, Shannon HS (1988) The JOHC-INCO mortality study. A study of mortality in workers engaged in the mining, smelting and refining of nickel. II: Mortality from cancer of the respiratoy tract and kidney. Special Report, McMaster University, 27 pp
Sunderman FW Jr (1984) Carcinogenicity of nickel compounds in animals. In: Sunderman FW Jr (ed-in-chief) Nickel in the human environment, IARC Scientific Publications, No. 53. Oxford University Press, Oxford, pp 127–142
Sunderman FW Jr, Hopfer SM, Knight JA, McCully KS, Cecutti AG, Thornhill PG, Conway K, Miller C, Patierno SR, Costa M (1987) Physicochemical characteristics and biological effects of nickel oxides. Carcinogenesis 8:305–313
Thomas DC, Whittemore AS (1988) Methods for testing interactions with applications to occupational exposures, smoking, and lung cancer. Am J Ind Med 13:131–147
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Andersen, I., Svenes, K.B. Determination of nickel in lung specimens of thirty-nine autopsied nickel workers. Int. Arch Occup Environ Heath 61, 289–295 (1989). https://doi.org/10.1007/BF00381428
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DOI: https://doi.org/10.1007/BF00381428