Abstract
An X-ray fluorescence (XRF) technique using plane polarized X-rays for excitation was used for in vivo measurements of cadmium in the kidney cortex among non-occupationally exposed members of the general population in southern Sweden. The measured concentrations of cadmium in the kidney cortex of smokers (median 28 μg/g, n = 10) were significantly higher (P = 0.0036) as compared to those in non-smokers (median 8 μg/g, n = 10), and so were the cadmium concentrations in blood and urine. The results show that smoking considerably increases the cadmium concentration in the kidney cortex and that smoking is a major source of cadmium exposure in the general population of Sweden. Except in the presence of very deeply situated kidneys, where the minimum detectable concentration is high, non-invasive in vivo XRF analysis of kidney cadmium should be a useful tool for evaluating the effects of long-term low-level exposure to cadmium and the risk of kidney damage.
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References
Ahlgren L, Mattsson S (1981) Cadmium in man measured in vivo by X-ray fluorescence analysis. Phys Med Biol 26:19–26
Bensryd I, Rylander L, Högstedt B, Aprea P, Bratt I, Fåhraéus C, Holmén A, Karlsson A, Nilsson A, Svensson B-L, Schütz A, Thomassen Y, Skerfving S (1994) Effect of acid precipitation on retention and excretion of elements in man. Sci Total Environ 145:81–102
Buchet JP, Lauwerys R, Roels H, et al. (1990) Renal effects of cadmium body burden of the general population. Lancet 336:699–702
Christoffersson JO (1986) In vivo elemental analysis in occupational medicine using X-ray fluorescence. Thesis, Lund University, Lund, Sweden
Christoffersson JO, Mattsson S (1983) Polarised X-rays in XRF-analysis for improved in vivo detectability of cadmium in man. Phys Med Biol 28:1135–1144
Christoffersson JO, Welinder H, Späng G, Mattsson S, Skerfving S (1987) Cadmium concentration in the kidney cortex of occupationally exposed workers measured in vivo using X-ray fluorescence analysis. Environ Res 42:489–499
Elinder C-G (1985a) Cadmium: uses, occurence, and intake. In: Friberg L, Elinder C-G, Kjellström T, Nordberg GF (eds) Cadmium and health: a toxicological and epidemiological appraisal, vol. 1. CRC Press, Boca Raton, Fl., pp 23–63
Elinder C-G (1985b) Normal values for cadmium in human tissues, blood, and urine in different countries. In: Friberg L, Elinder C-G, Kjellström T, Nordberg GF (eds) Cadmium and health: a toxicological and epidemiological appraisal, vol. 1. CRC Press, Boca Raton, Fl., pp 81–102
Elinder C-G, Kjellström T, Friberg L, Lind B, Linnman L (1976) Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Arch Environ Health 31:292–302
Elinder C-G, Kjellström T, Linnman L, Pershagen G (1978) Urinary excretion of cadmium and zinc among persons from Sweden. Environ Res 15:473–484
Elinder C-G, Friberg L, Lind B, Jawaid M (1983) Lead and cadmium levels in blood samples from the general population of Sweden. Environ Res 30:233–253
Ellis KJ, Vartsky D, Zanzi I, Cohn SH, Yasumura S (1979) Cadmium: in vivo measurement in smokers and nonsmokers. Science 205:323–325
Ellis KJ, Yasumura S, Vartsky D, Cohn SH (1983) Evaluation of biological indicators of body burden of cadmium in humans. Fundam Appl Toxicol 3:169–174
Franklin DM, Guthrie CJG, Chettle DR, Scott MC, Mason HJ, Davison AG, Newman Taylor AJ (1990) In vivo neutron activation analysis of organ cadmium burdens: referent levels in liver and kidney and the impact of smoking. Biol Trace Elem Res 26-27:401–406
ICRP, International Commission on Radiological Protection (1991) 1990 Recommendations of the International Commission on Radiological Protection, ICRP Publication 60, vol. 21, No. 1–3. Pergamon Press, Oxford
Järup L, Rogenfelt A, Elinder C-G, Nogawa K, Kjellström T (1983) Biological half-time of cadmium in the blood of workers after cessation of exposure. Scand J Work Environ Health 9:327–331
Kjellström T (1986) Renal effects. In: Friberg L, Elinder C-G, Kjellström T, Nordberg GF (eds) Cadmium and health: a toxicological and epidemiological appraisal, vol. 2. CRC Press, Boca Raton, Fl., pp 21–109
Kjellström T, Elinder C-G, Friberg L (1984) Conceptual problems in establishing the critical concentration of cadmium in human kidney cortex. Environ Res 33:284–295
Mattsson S, Scott MC (1990) In vivo elemental analysis using X-ray fluorescence: techniques and applications. In: Moro R, Cesareo R (eds) XRF and PIXE applications in life science. World Scientific, Singapore, pp 193–206
Morgan WD, Ryde SJS, Jones SJ, Wyatt RM, Hainsworth IR, Cobbold SS, Evans CJ, Braithwaite RA (1990) In vivo measurements of cadmium and lead in occupationally-exposed workers and an urban population. Biol Trace Elem Res 26-27:407–414
Nilsson U, Ahlgren L, Christoffersson J-O, Mattsson S (1990) Further improvements of XRF analysis of cadmium in vivo. In: Yasumura S, Harrison JE, McNeill KG, Woodhead AD, Dilmanian FA (eds) In vivo body composition studies. Plenum Press, New York, pp 297–301
Nordberg G (1993) Cadmium. In: Beije B, Lundberg P (eds) Criteria documents from the Nordic Expert Group 1992. Arbete och Hälsa 1993: 1, pp 85–124
Nordberg GF, Kjellström T, Nordberg M (1985) Kinetics and metabolism. In: Friberg L, Elinder C-G, Kjellström T, Nordberg GF (eds) Cadmium and health: a toxicological and epidemiological appraisal, vol. 1. CRC Press, Boca Raton, Fl., pp 103–178
Roels HA, Lauwerys RR, Buchet J-P, Bernard A, Chettle DR, Harvey TC, Al-Haddad IK (1981) In vivo measurement of liver and kidney cadmium in workers exposed to this metal: its significance with respect to cadmium in blood and urine. Environ Res 26:217–240
Stoeppler M, Brandt K (1980) Contributions to automated trace analysis. Part V. Determination of cadmium in whole blood and urine by electrothermal atomic absorption spectrophotometry. Z Anal Chem 300:372–380
Svartengren M, Elinder CG, Friberg L, Lind B (1986) Distribution and concentration of cadmium in human kidney. Environ Res 39:1–7
Svensson B-G, Björnham Å, Schütz A, Lettewall U, Nilsson A, Skerfving S (1987) Acidic deposition and human exposure to toxic metals. Sci Total Environ 67:101–115
Welinder H, Skerfving S, Henriksen O (1977) Cadmium metabolism in man. Br J Ind Med 34:221–228
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Nilsson, U., Schütz, A., Skerfving, S. et al. Cadmium in kidneys in Swedes measured in vivo using X-ray fluorescence analysis. Int. Arch Occup Environ Heath 67, 405–411 (1995). https://doi.org/10.1007/BF00381053
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DOI: https://doi.org/10.1007/BF00381053