Summary
A respiratory health questionnaire was administred to the workers producing man-made mineral fibers in three glasswool and two rockwool plants in France, in order to detect adverse effects resulting from fiber exposure. The mean ages of the 2024 male participants ranged from 32 to 41 years. The standardized questionnaire was filled in by the industrial physicians: occupational history, smoking habits, respiratory symptoms (cough, phlegm, dyspnea, asthma), irritative complaints of the upper airways (nasal fossae and sinuses, pharynx and larynx) were all recorded. Multiple unconditional logistic regression was used to test for a relationship between possible explanatory variables and these symptoms. The prevalence of respiratory symptoms (cough, phlegm, dyspnea) was strongly correlated with age and increased markedly among current smokers. Having adjusted for these confounding factors, significantly elevated Odds Ratios (ORs) for cough and phlegm were observed among the workers of one plant (51% of the whole study population) who had been exposed to fibers for a long time. In the same plant, the ORs for complaints of nasal fossae and sinuses increased significantly with the duration of fiber exposure, and one elevated OR was observed for pharyngeal and laryngeal symptoms. These findings were not consistent with the results observed in the four other plants (49% of the study population), since ORs for all these symptoms were either low or not significantly increased according to the duration of fiber exposure. This lack of similarity among plants could be explained either by differences in interviewers, age, seniority and tobacco consumption, or by secular changes in the industrial processes involved. The positive results observed contrast with a negative lung function study previously carried out in the same plant. Furthermore, the literature provides only one study reporting similar positive findings concerning pharyngeal and laryngeal complaints.
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References
Bayliss DL, Dement JM, Wagoner JK, Blejer HP (1976) Mortality patterns among fibrous glass production workers. Ann NY Acad Sci 271:324–335
Bertazzi PA (1976) Fibre di vetro: Esposizione e rischio per l'uomo. Med Lav 67:535–550
Bjure J, Soderholm B, Widimsky J (1964) Cardiopulmonary function studies in workers dealing with asbestos and glasswool. Thorax 19:22–27
Breslow NE, Day NE (1980) Statistical methods in cancer research. The analysis of case-control studies IARC Publication No 32, Vol 1
Cavelier C, Pham QT, Mur JM, Mereau P, Jannot P (1978) Etude clinique et fonctionnelle respiratoire chez les ouvriers noyauteurs de fonderie utilisant le procédé Ashland. Arch Mal Prof 39:607–615
Cavelier C, Robin H, Mur JM, Boulenguez C, Mereau P, Delebecq JF, Behaguel J (1979) Métallurgie de l'antimoine et fonction respiratoire. Résultats d'une enquête menée dans une entreprise de fabrication des oxydes d'étain et d'antimoine. Arch Mal Prof 40:795–803
Chiappino G, Scotti PG, Anselmino A (1981) Broncopneumopatie professionali da fibre vetrose. Osservazioni cliniche. Med Lav 72:96–101
Ciaccia A/di, Pusinanti F, Beltrami A, Fasano E (1978) Pneumoconiosi da fibre di lana di roccia. Riv Pat Clin Tuberc Pneumol 49:305–333
Grimm HG (1983) Befunde and bronchopulmonalen System bei Beschäftigten in der industriellen Herstellung und Weiterverarbeitung künstlicher mineralischer Fasern. Zbl Bakt Hyg I Abt Orig B 177:188–236
Grimm HG (1985) Querschnittsuntersuchung zur Frage gesundheitlicher Beeinträchtigungen des bronchopulmonalen Systems durch den Umgang mit künstlichen Mineralfasern. Proc Sixth Int Symp on Inhaled Particles. Cambridge 2–6 September
Hill JW, Whitehead WS, Cameron JD, Hedgecock GA (1973) Glass fibres: absence of pulmonary hazard in production workers. Br J Ind Med 30:174–179
Hill JW, Rossiter CE, Foden DW (1984) A pilot respiratory morbidity study of workers in a MMMF plant in the United Kingdom. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol 1:413–426
Kauffer E, Vigneron JC (1987) Étude épidémiologique dans l'industrie productrice de Fibres Minérales Artificielles. lère partie: Mesure des niveaux d'empussièrement. Arch Mal Prof 48:1–6
Kotin P (1984) Historical review of fibrogenicity and carcinogenicity of MMMF in experimental animals. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol 11:199–208
Lellouch J (1976) Le risque: définitions et procédés de calcul. Rev Epid Sant Publ 24:201–210
Maggioni A, Meregalli G, Sala C, Riva M (1980) Patologia respiratoira e cutanea negli addetti alla produzione di fibre di vetro (filato). Med Lav 71:216–227
Malmberg P, Hedenström H, Kolmodin-Hedman B, Krantz S (1984) Pulmonary function in workers of a mineral rock fibre plant. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol 1:427–435
McConnel EE, Wagner JC, Skidmore JW, Moore JA (1984) A comparative study of the fibrogenic and carcinogenic effects of UICC Canadian chrysotile B asbestos and glass microfibre (JM 100). In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol 11:234–250
Milby TH, Wolf CR (1969) Respiratory tract irritation from fibrous glass inhalation. J Occup Med 11:409–410
Molinini R, Pesola M (1979) Fibrosi polmonare diffusa in soggetto esposto all'inalazione di lana di vetro. Riv Med Lav Ing Ind 3:117–126
Moulin JJ, Pham QT, Mur JM, Meyer-Bisch C, Massin N, Wild P, Teculescu D, Perreaux JP, Hunzinger E, Kauffer E, Delepine P, Caillard JF (1985) Respiratory health of man-made mineral fibres production workers : results of an epidemiological survey in France. Proc Sixth Int Symp on Inhaled Particles, Cambridgde, 2–6 September. Ann Occup Hyg (in press)
Moulin JJ, Mur JM, Kauffer E, Meyer-Bisch C, Massin N (1986) Les risques professionnels dans l'industrie productrice de fibres minérales artificielles: analyse bibliographique des études épidémiologiques. Cahiers de Notes Documentaires de l'INRS, Paris, No. 123:131–144
Moulin JJ, Pham QT, Mur JM, Meyer-Bisch C, Caillard JF, Massin N, Wild P, Teculescu D, Delepine P, Perreaux JP, Hunzinger E (1987) Étude épidémiologique dans l'industrie productrice de Fibres Minerales Artificielles. 2ème partie: Symptômes respiratoires et function pulmonaire. Arch Mal Prof 48:7–16
Poirier R, Feliciano JM, Fondarai J, Kleisbauer JP, Laval P (1976) Etude epidemiologique de la bronchite chronique chez les ouvriers de la construction navale. Le poumon et le Coeur 23:241–246
Pott F, Schlipkôter HW, Ziem U, Spurny K, Huth F (1984) New results from implantation experiments with mineral fibres. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol 11:286–302
Rossiter CE (1984) The MRC and NIEHS studies: a further analysis. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol II:251–252
Saracci R, Simonato L (1982) Man-made vitreous fibers and workers' health. An overview of the epidemiologic evidence. Scand J Work Environ Health 8:234–242
Saracci R (1985) Man-made mineral fibers and health. Answered and unanswered questions. Scand J Work Environ Health 11:215–222
Skuric Z, Stahuljak-Beritic D (1984) Occupational exposure and ventilatory function changes in rock wool workers. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol I:436–437
Smidt U, Worth G, Bielert D (1977) Lung function and clinical findings in cross sectional and longitudinal studies in coal workers from the Ruhr area. Int Arch Occup Environ Health. 40:45–70
Smith DM, Ortiz LW, Archuleta RF (1984) Long-term exposure of Syrian hamsters and Osborne-Mendel rats to aerosolized 0.45 μm mean diameter fibrous glass. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen, Vol 1:253–272
Stanton MF, Wrench C (1972) Mechanisms of mesothelioma induction with asbestos and fibrous glass. J Natl Cancer Inst 48:797–821
Stanton MF, Layard M, Tegeris A, Miller E, May M, Kent E (1977) Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst 58:587–603
Wagner JC, Berry GB, Hill RJ, Munday DE, Skidmore JW (1984) Effects of inhalation and intrapleural inoculation in rats. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 22–22 April 1982. World Health Organization, Copenhagen, Vol II:209–233
Weill H, Hughes JM, Hammad YY, Glindmeyer HW, Sharon G, Jones RN (1983) Respiratory health in workers exposed to man-made vitreous fibers. Am Rev Respir Dis 128:104–112
Wright GW (1984) Respiratory morbidity of MMMF production workers — a review of previous studies. In: Biological Effects of Man-Made Mineral Fibres. Proc WHO/IARC Conference, Copenhagen 20–22 April 1982. World Health Organization, Copenhagen Vol 1:381–386
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Moulin, J.J., Wild, P., Mur, J.M. et al. Respiratory health assessment by questionnaire of 2024 workers involved in man-made mineral fiber production. Int. Arch Occup Environ Heath 61, 171–178 (1988). https://doi.org/10.1007/BF00381015
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DOI: https://doi.org/10.1007/BF00381015