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Determination and prediction of tissue-gas partition coefficients

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Summary

The head space method for determination of tissue-gas partition coefficients was modified to make it suitable for determination of tissue-gas partition coefficients of water soluble solvents. The method was used to determine tissue-gas partition coefficients of acetone, 2-butanone, methanol, ethanol, 1-propanol, 2-propanol and isobutanol for six representative tissues (muscle, kidney, lung, white and gray matter of brain, and adipose tissue). Blood-gas partition coefficients and distribution between plasma and erythrocytes were also determined. Relation between tissue-blood and fat-blood partition coefficients of 35 hydrophilic and hydrophobic substances of different chemical structure is described by linear correlation equations which can be used for prediction of tissue-gas partition coefficients of any chemical for which blood-gas and fat-gas partition coefficients are known. The correlation equations are based on all currently available data.

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Authors and Affiliations

  1. Department of Anesthesiology, University of Miami School of Medicine, Miami, Florida, USA

    Vera Fiserova-Bergerova & Maria L. Diaz

Authors
  1. Vera Fiserova-Bergerova
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  2. Maria L. Diaz
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This study was supported by NIH grant ES01029-09

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Fiserova-Bergerova, V., Diaz, M.L. Determination and prediction of tissue-gas partition coefficients. Int. Arch Occup Environ Heath 58, 75–87 (1986). https://doi.org/10.1007/BF00378543

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  • DOI: https://doi.org/10.1007/BF00378543

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