Summary
Cytogenetic and cytokinetic changes were examined using the differential staining method for sister chromatids in cultured lymphocytes from 16 female workers who had been occupationally exposed to up to 40 ppm of benzene for 1–20 years. While no increases in the number of structural and numerical chromosome aberrations nor any changes in cell-cycle kinetics were observed, a slight decrease in the frequency of sister-chromatid exchanges was detected. This apparently reverse finding of decreased sister-chromatid exchanges may be a manifestation of the subtler effect of the environmental chemical on the DNA replication mechanism. Possible dose-effect relationship in benzene-induced chromosome aberrations was discussed.
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Watanabe, T., Endo, A., Kato, Y. et al. Cytogenetics and cytokinetics of cultured lymphocytes from benzene-exposed workers. Int. Arch Occup Environ Heath 46, 31–41 (1980). https://doi.org/10.1007/BF00377457
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DOI: https://doi.org/10.1007/BF00377457