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External K+ increases Na+ conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells

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Abstract

We have observed a novel class of calcium-activated potassium channel which is activated by physiological levels of intracellular ATP. These KCa,ATP channels are found on smooth muscle cells isolated from the pulmonary artery. Since their activation by ATP is Mg2+ dependent and is poorly evoked by nonor slowly-hydrolyzed ATP analogues, we conclude that it involves phosphorylation. We suggest that in hypoxia a reduction of intracellular ATP may reduce KCa,ATP channel activity and thereby tend to depolarize the cells. This effect would increase Ca2+ entry through voltage-activated Ca2+ channels and contribute to vasoconstriction.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine Kyushu University, 812, Fukuoka, Japan

    A. Michael Frace, F. Maruoka & A. Noma

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  1. A. Michael Frace
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  2. F. Maruoka
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  3. A. Noma
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Frace, A.M., Maruoka, F. & Noma, A. External K+ increases Na+ conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells. Pflügers Arch 421, 94–96 (1992). https://doi.org/10.1007/BF00374739

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  • DOI: https://doi.org/10.1007/BF00374739

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