Abstract
Frequencies of equine leukocyte antigen distribution were determined by complement-mediated cytotoxicity testing among populations of Thoroughbred and Standardbred horses, including animals affected with equine sarcoid and laminitis. A highly significant association is described between the presence or history of sarcoid lesions in Thoroughbreds and the expression of the major histocompatibility complex (MHC)-encoded antigens, W3 and B1. No association was found between antigenic expression frequencies and laminitis in either breed. These findings suggest that a strong relationship exists between the equine MHC and a predisposition to sarcoid.
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Meredith, D., Elser, A.H., Wolf, B. et al. Equine leukocyte antigens: Relationships with sarcoid tumors and laminitis in two pure breeds. Immunogenetics 23, 221–225 (1986). https://doi.org/10.1007/BF00373016
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DOI: https://doi.org/10.1007/BF00373016