Summary
Levels of soluble IL-2 receptors, IL-6, soluble CD23, soluble CD14 and ECP (eosinophilic cationic protein) were measured as markers of T-cell, B-cell, monocyte and eosinophilic leucocyte activation in 26 patients with atopic dermatitis (AD) on admission to (A) and at discharge from (D) the Department of Dermatology in Zurich. The serum levels of sIL-2R, IL-6, sCD23, sCD14 and ECP were significantly elevated in AD patients in comparison with the normal values of healthy donors. A significant decrease in sIL-2R (p=0.0093) and in sCD14 (p=0.0134) levels was demonstrated between A and D, correlating with the improvement in the skin intensity score (SIS). In addition, a significant correlation of the sCD14 levels and the SIS at A was demonstrated (p=0.0415). These results also incriminate monocytes in the pathogenesis of AD, indicating that, besides sIL-2R and ECP, SCD14 could also be a possible marker for the disease activity.
Similar content being viewed by others
References
Bazil V, Horejsi V, Bandys M, Kristofova H, Strominger J, Kostka L, Hilgert J (1986) Biochemical characterisation of a soluble form of the 53 kDa monocyte surface antigen. Eur J Immunol 16: 1583–1589
Bujanowski-Weber J, Knöller I, Pfeil T, Luther H, Altmeyer P, König W (1990) Correlation of sCD23 release and immunoglobulin (E, A, G, M) synthesis by peripheral blood lymphocytes of atopic patients. Int Arch Allergy Appl Immunol 92: 113–118
Colver GB, Symons JA, Duff GW (1989) Soluble interleukin 2 receptor in atopic eczema. BMJ 298: 1426–1428
Grossman RM, Krueger J, Yourish D, et al (1989) Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 86: 6367–6371
Hanifin JM (1984) Atopic dermatitis. J Allergy Clin Immunol 73: 211–226
Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Derm Venereol [Suppl] (Stockh) 92: 44–47
Haziot A, Chen S, Ferrero E, Low G, Silber R, Goyert M (1988) The monocyte differentiation antigen CD14 is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol 141: 547–522
Hirano T, Akira Sh, Taga T, Kishimoto T (1990) Biological and clinical aspects of interleukin 6. Immunol Today 11: 443–448
Jakob T, Hermann K, Ring J (1991) Eosinophil cationic protein in atopic eczema. Arch Dermatol Res 283: 5–6
Juhlin L, Venge P (1991) Eosinophilic cationic protein (ECP) in skin disorders. Acta Derm Venereol [Suppl] (Stockh) 71: 495–501
KÄgi MK, Joller-Jemelka H, Wüthrich B (1992) Correlation of eosinophils, eosinophil cationic protein and soluble interleukin-2 receptor with the clinical activity of atopic dermatitis. Dermatology 185: 88–92
Kapp A, Piskorski A, Schöpf E (1988) Elevated levels of interleukin 2 receptor in sera of patients with atopic dermatitis and psoriasis. Br J Dermatol 119: 707–710
Kapp A, Czech W, Krutmann J, Schöpf E (1991) Eosinophil cationic protein in sera of patients with atopic dermatitis. J Am Acad Dermatol 24: 555–558
Müller KM, Röcken M, Joel D, Bonnefoy JY, Saurat JH, Hauser C (1991) Mononuclear cell-bound CD23 is elevated in both atopic dermatitis and psoriasis. J Dermatol Sci 2: 125–133
Paganelli R, Fanales-Belasio E, Carmini D, Scala E, Meglio P, Businco L, Aiuti F (1991) Serum eosinophil cationic protein in patients with atopic dermatitis. Int Arch Allergy Appl Immunol 96: 175–178
Rajka G (1989) Essential aspects of atopic dermatitis. Springer, Berlin Heidelberg New York
Robb RJ (1984) Interleukin 2: the molecule and its function. Immunol Today 5: 203–209
Walker C, Wüthrich B, KÄgi MK, Ingold P, Braun P, Bruijnzeel-Koomen CAFM, Blaser K (1992) Atopic dermatitis: correlation of peripheral blood T cell activation and eosinophilia with serum factors and clinical severity. Clin Exp Allergy (in press)
Wüthrich B (1975) Zur Immunpathologie der Neurodermitis constitutionalis. Eine klinisch-immunologische Studie mit besonderer Berücksichtigung der Immunglobuline E und der spezifischen Reagine im zeitlichen Verlauf. Huber, Bern Stuttgart Wien
Wüthrich B (1978) Serum IgE in atopic dermatitis. Clin Allergy 8: 241–248
Wüthrich B (1989) Atopic dermatitis flare provoked by inhalant allergens. Dermatologica 178: 51–53
Wüthrich B, Storck H, Grob P, Schwarz-Speck M (1972) Zur Immunpathologie der Neurodermitis. Arch Dermatol Forsch 244: 327–332
Wüthrich B, Joller-Jemelka H, Grob P, SpÄth P, Hasler D, Braun P (1989) Influence of mountain climate on immune parameters in atopic dermatitis, psoriasis and controls. In: Pichler WJ, Stadler BM, Dahinden CA, et al (eds) Progress in allergy and clinical immunology. Hogrefe & Huber, Toronto Lewiston New York, pp 344–352
Wüthrich B, Joller-Jemelka HJ, Grob PJ (1989) Serum interleukin-2-receptor levels in atopic dermatitis. Dermatologica 179: 57
Wüthrich B, Joller-Jemelka H, Helfenstein U, Grob PJ (1990) Levels of soluble interleukin-2 receptors correlate with the severity of atopic dermatitis. Dermatologica 181: 92–97
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wüthrich, B., KÄgi, M.K. & Joller-Jemelka, H. Soluble CD14 but not interleukin-6 is a new marker for clinical activity in atopic dermatitis. Arch Dermatol Res 284, 339–342 (1992). https://doi.org/10.1007/BF00372036
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00372036