Summary
In 21 male dogs a 4- to 10-cm sections of the urethra was replaced by an autologous vein graft. After an observation period of 21–380 days (mean 118), the results of radiological, endoscopic, macroscopic and histological examination were evaluated for 19 animals; 2 of the animals died perioperatively. Micturition was normal in 18 of 19 animals until they were killed. One animal died on the 30th day due to a high-grade meatal stenosis with a subsequent episode of urine retention and ascending urinary infection. Gross examination of the graft in this animal, however, revealed a good result. The local surrounding tissue was found to be ideal in 11 animals, and 5 showed satisfactory results. Three times we observed a pronounced stenosis, so that in these cases results were judged to be unsatisfactory. Postmortem examinations showed the neo-urethra to be a tube made up of connective tissue completely lined by urothelium. In our opinion the results of these animal experiments could at least be equalled in clinical application.
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Hübner, W., Rurka, I., Porpaczy, P. et al. Autologous everted vein graft for repairing long-section urethral defects. Urol Res 19, 131–134 (1991). https://doi.org/10.1007/BF00368191
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DOI: https://doi.org/10.1007/BF00368191