Abstract
K6, an influenza-specific cytotoxic T (Tc)-cell clone derived from C3H/He mice, was Dk-restricted. Further analysis showed that K6 also recognized Dd and Dq as allotargets. The clonal nature of the three recognition specificities was confirmed by cold-target cell inhibition. After extensive in vitro selection, K6 lost the ability to lyse Dd cells while retaining both other specificities. The role of the Lyt-2 molecule in antigen-specific self-H-2-restricted vs allospecific recognition was investigated by inhibition with the Lyt-2-specific monoclonal antibody 53-6.7. Both activities were proportionately inhibited, indicating that the Lyt-2 molecule is equally important for both recognition specificities of this Tc-cell clone.
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Wraith, D.C. Dk-restricted antiinfluenza cytotoxic t-cell clone loses one of its two alloreactivities. Immunogenetics 20, 131–139 (1984). https://doi.org/10.1007/BF00364485
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DOI: https://doi.org/10.1007/BF00364485