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Polymorphism of genes involved in anti-tubular basement membrane disease in rats

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Abstract

Inbred strains of rats differ widely in their susceptibility to interstitial nephritis induced by rabbit renal tubular basement membrane (TBM) preparations. We now report that susceptibility is determined in part by an RTI-linked gene for effector cell responsiveness producing interstitial lesions. Furthermore we also obtained evidence that the gene determining expression of the target TBM antigen is linked to the gene for albinism on the first linkage group. When non-susceptible rats lacking the TBM antigen but having the gene for cellular responsiveness were mated with non-susceptible rats which had the TBM antigen but lacked the gene for cellular responsiveness, the F1 hybrids were susceptible to the induction of interstitial nephritis. Although strains varied widely in the amount of anti-TBM antibody (αTBM-Ab) they produced, this variation does not appear to be controlled by RTI-linked genes, nor does the isotype or amount of antibody appear to be related to the susceptibility to infiltrating cellular lesions.

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Authors and Affiliations

  1. Renal Electrolyte Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania

    Eric G. Neilson, Eileen McCafferty & Bruce Zakheim

  2. Department of Human Genetics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania

    David L. Gasser

  3. Allergy-Immunology Section, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania

    S. Michael Phillips

Authors
  1. Eric G. Neilson
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  2. David L. Gasser
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  3. Eileen McCafferty
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  4. Bruce Zakheim
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  5. S. Michael Phillips
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Neilson, E.G., Gasser, D.L., McCafferty, E. et al. Polymorphism of genes involved in anti-tubular basement membrane disease in rats. Immunogenetics 17, 55–65 (1983). https://doi.org/10.1007/BF00364289

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  • DOI: https://doi.org/10.1007/BF00364289

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