Summary
Clinical data of 116 patients with chronic lymphocytic leukaemia (CLL) and of 114 patients with lymphoplasmacytic/lymphoplasmacytoid lymphoma (synonym: LP immunocytoma, IC) as diagnosed according to the Kiel classification were compared. This interim evaluation of a prospective multicenter study of the Kiel Lymphoma Study Group characterizes IC the less favorable lymphoma entity as evidenced by a more rapid lymph node enlargement, by a higher incidence of constitutional symptoms and of marked anaemia, and by a higher percentage of patients requiring early treatment. In addition, in IC autoimmune haemolytic anaemia was detected in 11.2% of investigated patients as compared to none of the patients with CLL, and monoclonal gammopathy was disclosed in 34.2% of investigated patients as compared to only three patients with CLL who could be, however, unrecognized cases of IC. Actuarial survival data after a follow-up period of 40 months are in favor of an overall better prognosis of patients with CLL than of patients with IC.
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Bagley CM Jr, DeVita VT Jr, Berard CW, Canellos GP (1972) Advanced lymphosarcoma: Intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone. Ann Intern Med 76: 227–234
Bartels H, Burger A, Common H, Donhuijsen-Ant R, Graubner M, Grupp HJ, Huhn D, Leopold H, Nowicki L, Nürnberger R, Rühl U, Waldner R (Kieler Lymphomgruppe) (1979) Klinik und Prognose des centroblastisch-centrocytischen Lymphoms und des centroblastischen Lymphoms. In: Stacher A, Höcker P (Hrsg) Lymphknotentumoren, Pathophysiologie, Klinik und Therapie. Urban u. Schwarzenberg, München Wien Baltimore, S 211–217
Brittinger G (für die Kieler Lymphomgruppe) (1978) Prospektive multizentrische Studie der Kieler Lymphomgruppe über die klinische Bedeutung der Kiel-Klassifikation der malignen Non-Hodgkin-Lymphome. Blut 36: 111–116
Brittinger G, Schmalhorst U, Bartels H, Fülle HH, Gerhartz H, Gremmel G, Grisar T, Grupp HJ, Gunzer U, Huhn D, Koeppen K-M, Kubanek B, Leopold H, Löffler H, Löhr GW, Nowicki L, Rühl U, Scmidt M, Stacher A, Theml H, Lennert K (Kiel Lymphoma Study Group) (1981) Principles and present status of a prospective multicenter study on the clinical relevance of the Kiel classification. Blut 43: 155–166
Brittinger G, Bartels H, Burger A, Dühmke E, Fülle HH, Gunzer U, Heinz R, Huhn D, Löhr GW, Musshoff K, Nowicki L, Pfoch M, Pralle H, Schmalhorst U (Kieler Lymphomgruppe) (1979) Grundlagen und bisherige Ergebnisse der prospektiven Studie der Kieler Lymphomgruppe über Non-Hodgkin-Lymphome. In: Stacher A, Höcker P (Hrsg) Lymphknotentumoren, Pathophysiologie, Klinik und Therapie. Urban u. Schwarzenberg, München Wien Baltimore, S 193–200
Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (1971) Report of the committee on Hodgkin's disease staging classification. Cancer Res 31: 1860–1861
Chenais F, Virella G, Young CD, Liu P, Whittle TS Jr (1977) Atypical B cell dyscrasia with Bence-Jones proteinuria and intracellular retention of γ-chains. Acta Haematol 58: 166–172
Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29: 252–260
Hobbs JR (1971) Immunocytoma o'mice an'men. Br Med J II: 67–72
Jamshidi K, Swaim WR (1971) Bone marrow biopsy with unaltered architecture: A new biopsy device. J Lab Clin Med 77: 335–342
Karnofsky DA, Burchenal JH (1948) The evaluation of chemotherapeutic agents against neoplastic disease. Cancer Res 8: 388–389
Knospe WH, Loeb V, Huguley CM (1974) Bi-weekly chlorambucil treatment of chronic lymphocytic leukemia. Cancer 33: 555–561
Krauss S, Sokal JE (1966) Paraproteinemia in the lymphomas. Am J Med 40: 400–413
Krüger GRF, Grisar T, Lennert K, Schwarze E-W, Brittinger G (Kiel Lymphoma Study Group) (1981) Histopathological correlation of the Kiel with the original Rappaport classification of malignant non-Hodgkin lymphomas. Blut 43: 167–181
Lennert K (1978) Malignant lymphomas other than Hodgkin's disease. Handbuch der speziellen pathologischen Anatomie und Histologie. 1. Band, Teil 3 B. Springer, Berlin Heidelberg New York, pp 209–251
Lennert K, Stein H, Kaiserling E (1975) Cytological and functional criteria for the classification of malignant lymphomas. Br J Cancer 31 [Suppl II]: 29–43
Meusers P, Bremer K, Bartels H, Brunswicker F, Burger A, Common H, Heinz R, Leopold H, Löffler H, Nowicki L, Vogt W, Waldner R (Kieler Lymphomgruppe) (1979) Klinik und Prognose des immunoblastischen Lymphoms. In: Stacher A, Höcker P (Hrsg) Lymphknotentumoren, Pathophysiologie, Klinik und Therapie. Urban u. Schwarzenberg, München Wien Baltimore, S 224–228
Pangalis GA, Nathwani BN, Rappaport H (1977) Malignant lymphoma, well differentiated lymphocytic. Its relationship with chronic lymphocytic leukemia and macroglobulinemia Waldenström. Cancer 39: 999–1010
Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (1975) Clinical staging of chronic lymphocytic leukemia. Blood 46: 219–234
Resegotti L, Palestro G, Coda R, Dolci C, Poggio E, Leonardo E (1977) Waldenström-like immunocytic lymphoma with IgG serum M component. Acta Haematol 58: 38–44
Schwarze E-W, Radaszkiewicz T, Pülhorn G, Goos M, Lennert K (1976) Maligne und benigne Lymphome des Auges, der Lid- und Orbitalregion. Virchows Arch [Pathol Anat] 370: 85–96
Stacher A, Bartels H, Bremer K, Brunswicker F, Common H, Fülle HH, Gunzer U, Leopold H, Nowicki L, Oerter D, Pralle H, Theml H, Waldner R (Kieler Lymphomgruppe) (1979) Klinik und Prognose der lymphoplasmozytoiden malignen Lymphome (Immunozytome). In: Stacher A, Höcker P (Hrsg) Lymphknotentumoren, Pathophysiologie, Klinik und Therapie. Urban u. Schwarzenberg, München Wien Baltimore, S 218–223
Stacher A, Waldner R, Theml H (Kieler Lymphomgruppe) (1976) Klinik der malignen Non-Hodgkin-Lymphome entsprechend der Kieler Klassifikation: Lymphoplasmozytoides Lymphom und chronisch lymphatische Leukämie. In: Löffler H (Hrsg) Maligne Lymphome und monoklonale Gammopathien. Hämatologie und Bluttransfusion, Vol. 18. Lehmann, München, S 199–209
Theml H, Burger A, Keiditsch E, Enne W, Eggert K, Dietzfelbinger H, Gräff L, Zsida L (1977) Klinische Beobachtungen zur Charakterisierung des splenomegalen Immunozytoms. Med Klin 72: 1019–1032
Theml H (1978) Die chronische lymphatische Leukämie. In: Begemann H (Hrsg) Leukämien. Springer, Berlin Heidelberg New York (Handbuch der inneren Medizin, 2. Band, 6. Teil, S 519–619)
Theml H, Pralle H, Bartels H, Common H, Gunzer U, Huhn D, Leopold H, Meusers P, Nowicki L, Scholle H, Waldner R, Weissenfels I (Kieler Lymphomgruppe) (1979) Offene Fragen zur Differentialdiagnose, Klinik und Therapie der chronischen lymphatischen Leukämie. In: Stacher A, Höcker P (Hrsg) Lymphknotentumoren, Pathophysiologie, Klinik und Therapie. Urban u. Schwarzenberg, München Wien Baltimore, S 201–206
Tursz T, Brouet J-C, Flandrin G, Danon F, Clauvel J-P, Seligmann M (1977) Clinical and pathologic features of Waldenström's macroglobulinemia in seven patients with serum monoclonal IgG or IgA. Am J Med 63: 499–502
Virella G, Monteiro JMN, Lopes-Virella MF, Soares AD, Fudenberg HH (1977) Asynchronous development of two monoclonal proteins (IgMλ and γ1 chains) in a patient with abdominal lymphoma. Cancer 39: 2247–2253
Ward AM, Shortland JR, Darke CS (1971) Lymphosarcoma of the lung with monoclonal (IgM) gammopathy. A clinicopathologic, histochemical, immunologic, and ultrastructural study. Cancer 27: 1009–1028
Wood TA, Frenkel EP (1967) An unusual case of macroglobulinemia. Arch Intern Med 119: 631–637
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Heinz, R., Stacher, A., Pralle, H. et al. Lymphoplasmacytic/lymphoplasmacytoid lymphoma: A clinical entity distinct from chronic lymphocytic leukaemia?. Blut 43, 183–192 (1981). https://doi.org/10.1007/BF00363888
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DOI: https://doi.org/10.1007/BF00363888