Skip to main content
Log in

Decreased number of α-motoneurons in the cervical intumescence of calves with Arthrogryposis Multiplex Congenita of both thoracic limbs

  • Research Article
  • Published:
Veterinary Research Communications Aims and scope Submit manuscript

Abstract

The number of α-motoneurons in the spinal cord segments C6 to Th2 of five calves with Arthrogryposis Multiplex Congenita (AMC) and of five normal calves was compared. A statistically highly significant reduction in the number of α-motoneurons in segment C6 was observed in the affected calves. Two hypotheses to explain the effect of these findings were proposed. Firstly, it was thought that AMC may result from paresis of some muscles of the girdle, shoulder and elbow. Secondly, it was postulated that the decrease in the number of α-motoneurons in C6 may have induced a radial nerve dysfunction resulting in AMC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Adams, R. W., 1975. Diseases of muscle. 3rd Edit. (Harper & Row, Hagerstow, Maryland), 230–315

    Google Scholar 

  • Badoux, D. M., 1975. General biostatics and biomechanics. In: Sisson and Grossman's. The anatomy of the domestic animals. 5th Edit. (W. B. Saunders Cy., Philadelphia), 48–83

    Google Scholar 

  • Betz, W. J., Caldwell, J. H. & Ribchester, R. R., 1980. The effects of partial denervation at birth on the development of muscle fibres and motor units in rat lumbrical muscle. Journal of Physiology, 303, 265–279

    Google Scholar 

  • Blood, D. C., Henderson, J. A. & Radostits, O. M., 1979. Veterinary medicine. 5th edit. (Tindall, London), 326–343

    Google Scholar 

  • Bonica, J. J., 1953. The management of pain. (Lea & Febiger, London), 318

    Google Scholar 

  • Brainerd, L. A., Burrows, W., Greenhill, J. P. & Hewitt, R. M., 1963. Dorland's illustrated medical dictionary. 23rd edit. (W. B. Saunders Cy, Philadelphia, London), 92.

    Google Scholar 

  • Brodal, A., 1981. Neurological anatomy in relation to clincial medicine. 3th edit. (Oxford University Press, New York, Oxford), 148–179

    Google Scholar 

  • Brown, L. M., Robson, M. J. & Sharrard, M. J. V., 1980. The patho-physiology of Arthrogryposis Multiplex Congenita Neurologica. Journal of Bone & Joint Surgery, 62-B, 291–296

    Google Scholar 

  • Brown, M. C., Jansen, J. K. S. & Van Essen, D., 1976. Polyneural innervation of skeletal muscle in new-born rats and its elimination during maturation. Journal of Physiology, 261, 387–422

    Google Scholar 

  • Chusid, J. G., 1982. Correlative neuroanatomy and functional neurology. 18th edit. (Lange Medical Publications, Los Altos, California), 175–196

    Google Scholar 

  • De Lahunta, A., 1977. Veterinary neuroanatomy and clinical neurology, 2nd edit. (W. B. Saunders Cy, Philadelphia), 57–88

    Google Scholar 

  • Drachman, D. B. & Banker, B. Q., 1961. Arthrogryposis Multiplex Congenita. Archives of Neurology, 5, 77–93

    Google Scholar 

  • Ellenberger, W. & Baum, H., 1974. Handbuch der vergleichende Anatomie der Haustiere. 18th Edit. (Springer Verlag, Berlin), 893–978

    Google Scholar 

  • Getty, R., 1975. Sisson and Grossman's. The anatomy of the domestic animals. 5th edit. (W. B. Saunders Cy, Philadelphia), 739–1151.

    Google Scholar 

  • Gillmour, J. R., 1946. Amyoplasia Congenita. Journal of Pathology, 58, 675–685

    Google Scholar 

  • Glücksmann, A., 1951. Cell deaths in normal vertebrate ontogeny. Biological Reviews, 26, 59–86

    Google Scholar 

  • Glücksmann, A., 1965. Cell death in normal development. Archives de Biology (Liège), 76, 419–437

    Google Scholar 

  • Goller, H., 1966. Kerngebiete des Rinderrückenmarkes. Zentralblatt für Veterinärmedizin. Reihe A, 10, 57–66

    Google Scholar 

  • Hughes, A. F., 1961. Cell degeneration in the larval ventral horn of Xenopus laevis (Daudin). Journal of Embryology & Experimental Morphology, 9, 269–284

    Google Scholar 

  • Innes, J. R. M. & Saunders, L. Z., 1962. Comparative neuropathology. (Academic Press, New York, London), 161–164

    Google Scholar 

  • Isaacs, H., Handelsmann, J. E., Badenhorst, M. & Pickering, A., 1977. The muscles in club foot—A histological, histo-chemical and electron microscopic study. Journal of Bone & Joint Surgery, 59-B, 465–472

    Google Scholar 

  • Jacobson, M., 1968. Developmental neurobiology, 2nd edit. (Plenum Press, New York, London), 281.

    Google Scholar 

  • Jones, T. C. & and Hunt, R. D., 1983, Veterinary pathology. 5th Edit. (Lea & Febiger, Philadelphia), 1135–1207.

    Google Scholar 

  • Jubb, K. V. F. & Kennedy, P. C., 1970. Pathology of domestic animals. 2nd Edit., Vol. 2 (Academic Press, New York, San Francisco, London), 456–458.

    Google Scholar 

  • Leipold, H. W., Cates, W. F., Radostits, O. M. & Howell, W. E., 1969. Spinal dysraphism, arthrogryposis and cleft palate in newborn Charolais calves. Canadian Veterinary Journal, 10, 268–273

    Google Scholar 

  • Lillie, R. D., 1965. Histopathologic technic and practical histochemistry, 3rd edit. (McGraw-Hill Book Cy, New York, Toronto, Sydney, London), 481

    Google Scholar 

  • Mayhew, I. G., 1984. Neuromuscular Arthrogryposis Multiplex Congenita in a thoroughbred foal. Veterinary Pathology, 21, 187–192

    Google Scholar 

  • Moore, D. C., 1973. Regional block. 4th edit. (Charles C. Thomas, Springfield, Illinois), 258

    Google Scholar 

  • Nickel, R., Schummer, A. & Seiferle, E., 1975. Lehrbuch der Anatomie der Haustiere. 3rd Edit., Band I, 460–483, Band IV, 199–221 (Paul Parey Verlag, Berlin).

    Google Scholar 

  • Prestige, M. C., 1967a. The control of cell number in the lumbar spinal ganglia during development of Xenopus laevis tadpoles. Journal of Embryology & Experimental Morphology 17, 453–471

    Google Scholar 

  • Prestige, M. C., 1967b. The control of cell number in the lumbar ventral horns of the development of Xenopus laevis tadpoles. Journal of Embryology & Experimental Morphology, 18, 359–387

    Google Scholar 

  • Price, D. S., 1933. A case of Amyoplasia Congenita, with pathological report. Archives of Disease in Childhood, 8, 343–354

    Google Scholar 

  • Redfern, P. A., 1970. Neuromuscular transmission in newborn rats. Journal of Physiology, 209, 701–709

    Google Scholar 

  • Rootman, D. S., Tatton, W. G. & Hay, M., 1981. Postnatal histogenetic death of rat forelimb motoneurons. Journal of Comparative Neurology, 199, 17–27

    Google Scholar 

  • Swatland, H. J., 1974. Developmental disorders of skeletal muscle in cattle, pigs and sheep. Veterinary Bulletin, 44, 179–203

    Google Scholar 

  • Van Huffel, X., Van Den Hende, C. & De Moor, A., 1986a. Aerobic and anaerobic metabolism of the Muscular Extensor Carpi Radialis and the Muscular Flexor Digitorum Superficials in calves with Arthrogryposis Multiplex Congenita (AMC) of both forelimbs. Journal of Veterinary Medicine A, 33, 551–55

    Google Scholar 

  • Van Huffel, X., Weyns, A., Van Nassauw, L. & De Moor, A., 1986b. Possible role of radial nerve dysfunction in the pathogenesis of Arthrogryposis Multiplex Congenita (AMC) of both forelimbs in calves. (preliminary results). 14th World Congress on Disease of Cattle. Dublin, Ireland. Aug. 26–29, 99–103

  • Warwick, R. & Williams, P. L., 1973. Gray's Anatomy. 35th Edit, (Longman), 1038–1039

  • Whittem, J. H., 1957. Congenital abnormalities in calves: arthrogryposis and hydranencephaly. Journal of Pathology & Bacteriology, 73, 375–387

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This work was supported by the IWONL, Brussels, Belgium.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Van Huffel, X., Weyns, A., Van Nassauw, L. et al. Decreased number of α-motoneurons in the cervical intumescence of calves with Arthrogryposis Multiplex Congenita of both thoracic limbs. Veterinary Research Communications 12, 237–243 (1988). https://doi.org/10.1007/BF00362806

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00362806

Keywords

Navigation