Differenzierung der Wirkungen von CO₂-Druck und Wasserstoffionenkonzentration im Blut auf die Atmung beim Menschen

Summary

Data published in the preceding paper on effects of augmented arterial CO₂ tensions on lung ventilation before and after inducing acidosis by NH₄Cl or CaCl₂ or acetazolamide (diamox) were used to differentiate the partial effects of p _H changes at constant CO₂ tension and of CO₂ tension changes at constant p _H in arterial blood on lung ventilation.

The total increase of lung ventilation caused by elevation of CO₂ tension was found to be 3.2 l min⁻¹ Torr⁻¹. The partial p _H effect was 1.4 l min⁻¹ Torr⁻¹ or 43% per cent of the total effect and the partial CO₂ effect was 1.8 l min⁻¹ Torr⁻¹ or 57 per cent of the total effect. This is in agreement with the prediction of Gray and the experimental results of Lambertsen and Semple.