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Characterization and mapping of the human SOX4 gene

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Abstract

The SOX genes comprise a large family related by homology to the HMG-box region of the testis-determining gene SRY. We have cloned and sequenced the human SOX4 gene. The open reading frame encodes a 474 amino acid protein, which includes an HMG-box. The non-box sequence is particularly rich in serine residues and has several polyglycine and polyalanine stretches. With somatic cell hybrids, human SOX4 has been mapped to Chromosome (Chr) 6p distal to the MHC region. There is no evidence for clustering of other members of the SOX1,-2, and-3 or SOX4 gene families around the SOX4 locus.

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Authors and Affiliations

  1. Department of Genetics, University of Cambridge, Downing Street, CB2 3EH, Cambridge, UK

    Christine J. Farr & Peter N. Goodfellow

  2. Department of Anatomy, St. George's Medical School, Crammer Terrace, SW17 ORE, London, UK

    David J. Easty

  3. Division of Medical and Molecular Genetics, UMDS, Guy's Hospital, London Bridge, SE1 9RT, London, UK

    Jiannis Ragoussis

  4. Laboratory of Eukaryotic Molecular Genetics, MRC National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK

    Jerome Collignon & Robin Lovell-Badge

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  1. Christine J. Farr
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  2. David J. Easty
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  3. Jiannis Ragoussis
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  4. Jerome Collignon
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  5. Robin Lovell-Badge
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  6. Peter N. Goodfellow
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Farr, C.J., Easty, D.J., Ragoussis, J. et al. Characterization and mapping of the human SOX4 gene. Mammalian Genome 4, 577–584 (1993). https://doi.org/10.1007/BF00361388

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  • DOI: https://doi.org/10.1007/BF00361388

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