References
Baldwin, C.T., Hoth, C.F., Amos, J.A., da-Silva, E.O., Milunsky, A. (1992). An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome. Nature 355, 637–638.
Chalepakis, G., Fritsch, R., Fickenscher, H., Deutsch, U., Goulding, M., Gruss, P. (1991). The molecular basis of the undulated/Pax-1 mutation. Cell 66, 873–884.
Epstein, D.J., Vekemans, M., Gros, P. (1991). Splotch (Sp 2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67, 767–774.
Gruss, P., Walther, C. (1992). Pax in development. Cell 69, 719–722.
Hayasaka, I., Nakatsuka, T., Fujii, T., Naruse, I., Oda, S. (1980). Polydactyly Nagoya, Pdn: a new mutant gene in the mouse. Exp. Anim. 29, 391–395.
Hill, R.E., Favor, J., Hogan, B.L.M., Ton, C.C.T., Saunders, G.F., Hanson, I.M., Prosser, J., Jordan, T., Hastie, N.D., van Heyningen, V. (1991). Mouse small eye results from mutations in a paired-like homeobox containing gene. Nature 354, 522–525.
Hoth, C.F., Milunsky, A., Lipsky, N., Sheffer, R., Clarren, S.K. (1993). Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I). Am. J. Hum. Genet. 52, 455–462.
Hui, C., Joyner, A.L. (1993). A mouse model of Greig-cephalopolysyndactyly syndrome: the extra-toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genet. 3, 241–246.
Johnson, D.R. (1967). Extra-toes: a new mutant gene causing multiple abnormalities in the mouse. J. Embryol. Exp. Morphol. 17, 543–581.
Little, M.H., Prosser, J., Condie, A., Smith, P.J., van Heyningen, V., Hastie, N. (1992). Zinc finger point mutations within the WT1 gene in Wilms tumor patients. Proc. Natl. Acad. Sci. USA 89, 4791–4795.
Lyon, M.F., Morris, T., Searle, A.G., Butler, J. (1967). Occurrences of linkage of the mutant ‘extra-toes’ in the mouse. Genet. Res. 9, 383–385.
Naruse, I., Kameyama, Y. (1982). Morphogenesis of genetic preaxial polydactyly, Polydactyly Nagoya, Pdn, in mice. Cong. Anom. 22, 137–144.
Naruse, I., Kato, K., Asano, T., Suzuki, F., Kameyama, Y. (1990). Developmental brain abnormalities accompanied with the retarded production of S-100β protein in genetic polydactyly mice. Dev. Brain Res. 51, 253–258.
Oda, S., Naruse, I., Hayasaka, I., Kameyama, Y. (1982). Linkage of Pdn (Polydactyly Nagoya) and bg (beige) on chromosome no. 13 in the mouse. Ann. Res. Inst. Environ. Med., Nagoya University 33, 284–285.
Pohl, T.M., Mattei, M.G., Rüther, U. (1990). Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). Development 110, 1153–1157.
Ruppert, J.M., Vogelstein, B., Arheden, K., Kinzler, K.W. (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell Biol. 10, 5408–5415.
Schimmang, T., Lemaistre, M., Vortkamp, A., Rüther, U. (1992). Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 116, 799–804.
Tassabehji, M., Read, A.P., Newton, V.E., Harris, R., Balling, R., Gruss, P., Strachan, T. (1992). Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 355, 635–637.
Van der Hoeven, F., Schimmang, T., Vortkamp, A., Rüther, U. (1993). Molecular linkage of the morphogenetic mutation add and the zinc finger gene Gli3. Mamm. Genome 4, 276–277.
Vortkamp, A., Gessler, M., Grzeschik, K.-H. (1991). GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352, 539–540.
Vortkamp, A., Franz, T., Gessler, M., Grzeschik, K.-H. (1992). Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra-toes (Xt). Mamm. Genome 3, 461–463.
Wagner, K., Kroisel, P.M., Rosenkranz, W. (1992). Localization of genes and anonymous DNA probes on the short arm of chromosome 7. Mamm. Genome 3, 39–41.
Winter, R.M., Huson, S.M. (1988). Greig cephalopolysyndactyly syndrome: a possible mouse homologue (Xt-extra toes). Am. J. Med. Genet. 31, 793–798.
Zarkower, D., Hodgkin, J. (1992). Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins. Cell 70, 237–249.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schimmang, T., Oda, SI. & Rüther, U. The mouse mutant Polydactyly Nagoya (Pdn) defines a novel allele of the zinc finger gene Gli3. Mammalian Genome 5, 384–386 (1994). https://doi.org/10.1007/BF00356560
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00356560