Summary
Unstable mutations were generated at the cut locus by the MR-h12 factor which induces male recombination. The unstable allele ct MR2, containing the MR-transposon in the cut locus is a very powerful mutator producing a number of different viable and lethal mutations both in the cut locus and outside it.
I describe several types of mutations: stable reversion to wild type, which were sometimes associated with the appearance of unstable mutations in other loci; of stable deficiencies at the cut locus (lethals); new unstable mutations at different loci with the ct MR2 allele conserved; new unstable cut alleles with a phenotype other than that of ct MR2. The possible mechanisms of these mutational events are discussed. The genetic system constructed in the present work affords an opportunity for molecular studies of the cut locus and the MR-transposon, as a sequence from the cut locus has recently been cloned (Tchurikov et al. 1981).
Similar content being viewed by others
References
Finnegan DJ, Rubin GM, Young MW, Hogness DS (1978) Repeated gene families in Drosophila melanogaster. Cold Spring Harbor Symp Quant Biol 42:1053–1063
Georgiev GP, Ilyin YuN, Ryskov AP, Tchurikov NA, Yenikolopov GN, Gvozdev VA, Ananiev EV (1977) Isolation of eukaryotic DNA fragments containing structural genes and the adjasent sequences. Science 195:394–396
Georgiev GP, Ilyin YuN, Ryskov AP, Kramerov DA (1981) Mobile dispersed genetic elements in eukaryotes and their possible relation to cancerogenesis. Genetika (Russ.) XYII:222–232
Golubovsky MD, Ivanov YuN, Green MM (1977) Genetic instability in Drosophila melanogaster: Putative multiple insertion mutants at the bristle locus. Proc Natl Acad Sci USA 74:2973–2975
Green MM (1967) The genetic of mutable gene at the w locus of Drosophila melanogaster. Genetics 56:467–477
Green MM (1977) Genetic instability in Drosophila melanogaster: De novo induction of putative insertion mutations. Proc Natl Acad Sci USA 74:3490–3493
Johnson TK, Judd BH (1979) Analysis of the cut locus of Drosophila melanogaster. Genetics 92:485–502
Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. In: Carnegie Institute of Washington Publication, No 627
Tchurikov NA, Naumova AK, Zelentsova ES, Georgiev GP (1981) Cloning and characterization of unique gene of D. melanogaster locat in the region of cut locus. Proc Acad Sci USSR 258:1459–1462
Thompson JN, Woodruff RC (1978) Mutator genes: pasemakers of evolution. Nature 274:317–321
Voss R, Falk R (1973) The nature of reverse mutations of Drosophila melanogaster. Mutat Res 20:221–234
Author information
Authors and Affiliations
Additional information
Communicated by Ch. Auerbach
Rights and permissions
About this article
Cite this article
Gerasimova, T.I. Genetic instability at the cut locus of Drosophila melanogaster induced by the MR-h12 chromosome. Mol Gen Genet 184, 544–547 (1981). https://doi.org/10.1007/BF00352537
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00352537