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Molecular biology of breast carcinoma

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Abstract

During the last several years basic research has resulted in the identification of many of the factors involved in signal transduction pathways, leading us to a greater understanding of the mechanisms of growth control in breast cancer cells. Many of these factors are the products of proto-oncogenes or suppressor genes. This review describes the role of some of these factors in breast cancer development, progression, and metastasis and discusses implications for future directions.

Résumé

Pendant ces dernières années, la recherche fondamentale a permis d'identifier les chemins qu'empruntent les signaux de transduction aidant ainsi à comprendre les mécanismes de contrôle de la croissance des cellules cancéreuses du sein. Beaucoup de ces facteurs sont des produits de proto-oncogènes on des gènes represseurs. Cette revue décrit le rôle de certains de ces facteurs dans le développement du cancer du sein, dans leur évolution et leur diffusion métastatique. Les implications de l'avenir sont discutées.

Resumen

En los últimos años la investigación básica ha permitido identificar muchos de los factores involucrados en las vías celulares y moleculares de transducción de señales, lo cual nos da una mejor comprensión de los mecanismos de control del crecimiento de las células del cáncer mamario. Muchos de los factores promotores son los productos de proto-oncogenes y de genes supresores. La presente revisión describe el papel de algunos de estos factores en el desarrollo del cáncer mamario, de su progresión y de la aparición de metástasis, y discute las implicaciones para futuras directrices de manejo.

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  1. Department of Biochemistry and Molecular Biology, Lombardi Cancer Research Center, Georgetown University medical Center, 3800 Reservoir Road, 20007, Washington, D.C., USA

    Dorraya El-Ashry Ph.D.

  2. Department of Medicine Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, 20007, Washington, D.C., USA

    Marc E. Lippman M.D.

  3. Department of Pharmacology, Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, 20007, Washington, D.C., USA

    Marc E. Lippman M.D.

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El-Ashry, D., Lippman, M.E. Molecular biology of breast carcinoma. World J. Surg. 18, 12–20 (1994). https://doi.org/10.1007/BF00348187

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