Abstract
Genetic methods, especially segregation and linkage analysis and supplementary tests on identity by descent and phenotype distributions, help to clarify the etiology of multiple sclerosis (MS). They reveal two determinants, one tightly linked to DR2 haplotypes in the HLA system, the other unlinked, which interact to simulate loose linkage.
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Ho, H.Z., Tiwari, J.L., Haile, R.W. et al. HLA-linked and unlinked determinants of multiple sclerosis. Immunogenetics 15, 509–517 (1982). https://doi.org/10.1007/BF00345910
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DOI: https://doi.org/10.1007/BF00345910