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Viral infections in severely immunocompromised cancer patients

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Abstract

Immunocompromised cancer patients are susceptible to infection by many viral pathogens. The most serious morbidity results from active infection by members of the herpes virus family. Reactivation of latent virus occurs as a sequela of cytotoxic therapy and deficiency of cell-mediated immunity, especially cytotoxic responses, the major host protective defense. Herpes simplex virus and varicella zoster virus infections are problematic in patients with all types of cancer; cytomegalovirus infections cause life-threatening morbidity in bone marrow transplant patients. Several antiviral agents are highly active against these pathogens and different strategies of using them have resulted in reduced morbidity and mortality. Ultimately, the resolution of these infections is dependent on the control of the malignancy and the ability of the patient to mount an adequate immune response.

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  1. Bone Marrow Transplant Program, Emory University School of Medicine, The Emory South Clinic, Room 2727, 1327 Clifton Road, N. E., 30322, Atlanta, GA, USA

    Steven M. Devine & John R. Wingard

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Devine, S.M., Wingard, J.R. Viral infections in severely immunocompromised cancer patients. Support Care Cancer 2, 355–368 (1994). https://doi.org/10.1007/BF00344048

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