Summary
Regional cerebral blood flow (CBF), blood volume (CBV) and oxygen metabolic rate (CMRO2) were evaluated and compared among normals, patients with recent reversible ischaemic attacks (RIAs) and patients with chronic minor infarction using positron emission tomography. Average CBF together with CMRO2 significantly decreased in the infarction group in the middle cerebral artery territory of the affected hemisphere while the mean values for RIAs were intermediate between the other two groups. CBV also reduced, however it was more preserved compared to flow as seen in decreased CBF/CBV values. Significant interhemispheric difference was found in CBF/CBV ratio, but it did not clearly correlate with OEF changes. Higher OEF was noted only in the restricted brain regions of RIAs where CBF showed large hemispheric asymmetry. However, in other regions, the coupled decline of blood flow and metabolism was found which suggests tissue damage or neuronal cell loss in the brain with previous RIA symptoms.
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References
Loeb C (1985) Les attaques ischemiques transitoires. Une revision est-elle necessaire? Neurol (Paris) 141:694–697
Millikan CH, McDowell FH (1978) Treatment of transient ischemic attacks. Progress in cerebrovascular disease. Stroke 9: 299–308
Toole JF, Yuson CP, Janeway R, Johnston F, Davis C, Cordell AR, Howard G (1978) Transient ischemic attacks: a prospective study of 255 patients. Neurology 28:746–753
Muuronen A, Kaste M (1982) Outcome of 314 patients with transient ischemic attack. Stroke 13:24–31
Brambilla GL, Prencipe M, Mariani F, Tomasello F, Candelise L, Argentino C, Bono G, De Zanche L, Inzitari D, Nardini M, Fieschi C (1983) Italian multicenter study on reversible cerebral ischemic attacks: 1 — Population characteristics and methodology including clinical rehabilitation. Stroke 14: 424–431
Warlow C (1982) Transient ischemic attacks. In: Mattews WB, Glasen GH (eds) Clinical Neurology, 3rd edn. Churchill Livingstone, Edinburgh, pp 191–214
Gibbs JM, Wise RJS, Leenders KL, Jones T (1984) Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet 1:310–314
Powers WJ, Grubb RLJ, Raichle ME (1984) Physiological responses to focal cerebral ischemia in humans. Ann Neurol 16:546–552
Powers WJ, Grubb RLJ, Darriet D, Raichle ME (1985) Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 5:600–608
Powers WJ, Raichle ME, Grubb RLJ (1985) Positron emission tomography to assess cerebral perfusion. Lancet 1: 102–103
Gibbs JM, Wise RJS, Leenders KL, Herold S, Frackowiak RSJ, Jones T (1985) Cerebral haemodynamics in occlusive carotid-artery disease. Lancet 1:933–934
Itoh M, Matsuzawa T, Yosioka S, Fukuda H, Endo S, Yamada K, Abe Y, Kubota K, Sato T, Ido T, Ikku Y (1981) Performance evaluations of a positron computed tomography; ECAT II. CYRIC Annual Report 2:237–239
Watanuki S, Ido T, Itoh M, Matsuzawa T (1984) Movement monitor for patients on positron emission tomography. CYRIC Annual Report 5:231–235
Grubb RLJ, Richle ME, Higgins CS, Eichling JO (1978) Measurement of regional cerebral blood volume by emission tomography. Ann Neurol 4:323–328
Phelps ME, Huang SC, Hoffman EJ, Kuhl DE (1979) Validation of tomographic measurement of cerebral blood volume with C-11 labelled carboxy-haemoglobin. J Nucl Med 20: 328–334
Frackowiak RSJ, Lenzi GL, Jones T, Heathers JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: Theory, procedure, and normal values. J Comput Assist Tomogr 4:727–736
Lammertsmma AA, Jones T (1983) Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab 3: 416–424
Meyer JS, Rogers RL, Mortel KF (1984) Progressive cerebral ischemia antedates cerebrovascular symptoms by two years. Ann Neurol 16:314–320
Frackowiak RSJ (1985) Pathophysiology of human cerebral ischemia: Studies with positron tomography and 15Oxygen. In: Sokoloff L (ed) Brain imaging and brain function. Raven, New York, pp 139–161
Knapp WH, Kummer R, Kuebler W (1986) Imaging of cerebral blood flow to volume distribution using SPECT. J Nucl Med 27:465–470
Kuhl DE, Phelps ME, Kowell AP, Metter EJ, Selin C, Winter J (1980) Effects of stroke on local cerebral metabolism and perfusion: mapping by emission computed tomography of 18FDG and 13NH3. Ann Neurol 8:47–60
Powers WJ, Raichle ME (1985) Positron emission tomography and its application to the study of cerebrovascular disease in man. Stroke 16:361–376
Mohr JP (1982) Lacunes. Stroke 13:3–11
Lassen NA (1982) Incomplete cerebral infarction — focal incomplete ischemic tissue necrosis not leading to embolization. Stroke 13:522–523
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Itoh, M., Hatazawa, J., Pozzilli, C. et al. Haemodynamics and oxygen metabolism in patients after reversible ischaemic attack or minor ischaemic stroke assessed with positron emission tomography. Neuroradiology 29, 416–421 (1987). https://doi.org/10.1007/BF00341736
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DOI: https://doi.org/10.1007/BF00341736