Skip to main content
Log in

Cell degeneration and mitosis in the buccopharyngeal and branchial membranes in the mouse embryo

  • Published:
Anatomy and Embryology Aims and scope Submit manuscript

Summary

The frequencies of cell degeneration and mitosis were investigated in the rupturing buccopharyngeal membrane (BPM) and in the persistent first branchial membrane (BM). In the BPM, cell degeneration starts many hours before rupture is visible, but mitotic figures are absent. In the BM this situation is reversed: mitotic figures are regularly observed, but a degenerating cell only occasionally. It is concluded that the ratio between the numbers of degenerating and dividing cells regulates the fate of both the BPM and the BM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ernst M (1926) Ueber Untergang von Zellen während der normalen Entwicklung bei Wirbeltieren. Zeitschr Anat Entwickl-Gesch 79:228–262

    Google Scholar 

  • Ferguson MWJ (1981) Developmental mechanisms in normal and abnormal palate formation with particular reference to the aetiology, pathogenesis and prevention of cleft palate. Brit J Orthod 8:115–137

    Google Scholar 

  • Gaare JD, Langman J (1980) Fusion of nasal swellings in the mouse embryo. Anat Embryol 195:85–99

    Google Scholar 

  • Geelen JAG, Langman J (1977) Closure of the neural tube in the cephalic region of the mouse embryo. Anat Rec 189:625–640

    Google Scholar 

  • Glücksmann A (1930) Ueber die Bedeutung von Zellvorgängen für die Formbildung epithelialer Organe (Linse, Augenblase, Neuralrohr usw). Z Anat Entwickl-Gesch 93:35–93

    Google Scholar 

  • Glücksmann A (1951) Cell deaths in normal vertebrate ontogeny. Biol Rev 26:59–86

    Google Scholar 

  • Goedbloed JF, Smits-van Prooije AE A quantitative analysis of the temporal pattern of somite formation in mouse and rat. A simple and accurate method for age determination. (submitted)

  • Greene RM, Pratt RM (1977) Inhibition by diazo-oxo-norleucine (DON) of rat palatal glycoprotein synthesis and epithelial cell ahesion in vitro. Exp Cell Res 105:27–37

    Google Scholar 

  • Greene RM, Pratt RM (1978) Inhibition of epithelial cell death in the secondary palate in vitro by alteration of lysosome function. J Histochem Cytochem 26:1109–1114

    Google Scholar 

  • Karnovsky MJ (1965) A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J Cell Biol 27:137A

    Google Scholar 

  • Mangold U, Offenbächer T, Kaufmann P (in press) Zur Morphogenese der Kiemenbogenmembranen der Ratte. Anat Anz

  • Poelmann RE (1980) Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early postimplantation mouse embryos. J Embryol Exp Morphol 55:33–51

    Google Scholar 

  • Poelmann RE, Vermey-Keers C (1976) Cell degeneration in the mouse embryo: a prerequisite for normal development. In: Müller-Bérat N et al. (eds) Progress in differentiation Research North-Holland Publishing Co, pp 93–102

  • Pratt RM, Greene RM (1976) Inhibition of palatal epithelial cell death by altered protein synthesis. Dev Biol 54:135–145

    Google Scholar 

  • Saunders JW (1966) Death in embryonic systems. Science NY 154:604–612

    Google Scholar 

  • Schook P (1980) A spatial analysis of localization of cell division and cell death in relationship with the morphogenesis of the chick optic cup. Acta Morphol Neerl-Scand 18:213–229

    Google Scholar 

  • Theiler K (1969) Die Anlage des Vorderdarmes bei der Hausmaus und die Furchenbildungen am Eicylinder. Z Anat Entwickl-Gesch 128:40–46

    Google Scholar 

  • Vermeij-Keers C (1972) Degeneration in the epithelial plate of Hochstetter in the mouse: a light and electron microscopic study. Acta Morphol Neerl-Scand 9:386–387

    Google Scholar 

  • Vermeij-Keers C, Mazzola RF, van der Meulen JC, Stricker M (1983) Cerebro-craniofacial and craniofacial malformations. J Cleft Palate 20:128–145

    Google Scholar 

  • Waterman RE (1977) Ultrastructure of oral (buccopharyngeal) membrane formation and rupture in the hamster. Dev Biol 58:219–229

    Google Scholar 

  • Waterman RE, Kao R (1982) Formation of the mouth opening in the zebrafish embryo. SEM III 1249–1257

    Google Scholar 

  • Waterman RE, Schoenwolf GC (1980) The ultrastructure of oral (buccopharyngeal) membrane formation and rupture in the chick embryo. Anat Rec 197:441–470

    Google Scholar 

  • Wyllie AH (1981) Cell death, a new classification separating apoptosis from necrosis. In: Bowen JD, Lockshin RA (eds) Cell death in biology and pathology Chapmann and Hall London, pp 9–29

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Poelmann, R.E., Dubois, S.V., Hermsen, C. et al. Cell degeneration and mitosis in the buccopharyngeal and branchial membranes in the mouse embryo. Anat Embryol 171, 187–192 (1985). https://doi.org/10.1007/BF00341413

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00341413

Key words

Navigation