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An electron microscope study on the termination of the perforant path fibres in the hippocampus and the fascia dentata

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Summary

Morphology and distribution of the perforant path fibres in the hippocampus and the fascia dentata of the rat have been studied in the electron microscope. Investigations were carried out on normal tissue as well as on tissue degenerating after entorhinal damage. The perforant path fibres were relatively thin and the terminals small. Two terminal fields were found to be of quantitative importance, one in the middle third of stratum moleculare of the fascia dentata, the other in stratum lacunosum moleculare of regio inferior of the hippocampus. Some of the observations have been expressed in numerical terms.

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References

  • Alksne, J. F., T. W. Blackstad, F. Walberg, and L. E. White jr.: Electron microscopy of axon degeneration: A valuable tool in experimental neuroanatomy. Ergebn. Anat. Entwickl.- Gesch. 39, 3–31 (1966).

    CAS  Google Scholar 

  • Andersen, P.: Localization of microelectrode sites by silver impregnation. Acta physiol. scand. 35, 305–311 (1956).

    Article  CAS  PubMed  Google Scholar 

  • T. W. Blackstad, and T. Lömo: Location and identification of excitatory synapses on hippocampal pyramidal cells. Exp. Brain Res. 1, 236–248 (1966).

    Article  CAS  PubMed  Google Scholar 

  • —, and C. J. Eccles: Locating and identifying postsynaptic inhibitory synapses by the correlation of physiological and histological data. Symp. Biol. Hung. 5, 219–242 (1965).

    Google Scholar 

  • B. Holmqvist, and P. E. Voorhoeve, a) Entorhinal activation of dentata granule cells. Acta physiol. scand. 66, 448–460 (1966).

    Article  CAS  PubMed  Google Scholar 

  • —, b) Excitatory synapses on hippocampal apical dendrites activated by entorhinal stimulation. Acta physiol. scand. 66, 461–472 (1966).

    Article  CAS  PubMed  Google Scholar 

  • Blackstad, T. W.: On the termination of some afferents to the hippocampus and fascia dentata. Acta anat. (Basel) 35, 202–214 (1958).

    Article  CAS  Google Scholar 

  • Cajal, S. Ramon Y: Studien über die Hirnrinde des Menschen. 4. Heft: Die Riechrinde beim Menschen und Säugetier. Leipzig: Johann Ambrosius Barth 1903.

    Google Scholar 

  • Caulfield, J. B.: Effects of varying the vehicle for Os2O4 in tissue fixation. J. biophys. biochem. Cytol. 3, 827–830 (1957).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gray, E. G.: Axosomatic and axodendritic synapses of the cerebral cortex. An electron microscope study. J. Anat. (Lond.) 93, 420–433 (1959).

    CAS  Google Scholar 

  • Holt, S. J., and R. M. Hicks: Studies on formalin fixation for electron microscopy and cytochemical staining purposes. J. biophys. biochem. Cytol. 11, 31–45 (1961).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lorento de Nó, R.: Studies on the structure of the cerebral cortex. II. Continuation of the study of the Ammonic system. J. Psychol. Neurol. (Lpz.) 46, 113–177 (1934).

    Google Scholar 

  • Nafstad, P. H. J., and T. W. Blackstad: Relative volume of mitochondria in different parts of cortical neurons. Z. Zellforsch. 73, 234–245 (1966).

    Article  CAS  PubMed  Google Scholar 

  • Nauta, W. J. H.: Über die sogenannte terminale Degeneration im Zentralnervensystem und ihre Darstellung durch Silberimprägnation. Schweiz. Arch. Neurol. Psychiat. 66, 353–376 (1950).

    CAS  Google Scholar 

  • Pearson, E. S., and H. O. Hartley: Biometrica tables for statisticans, vol. I. Cambridge: University Press 1962.

    Google Scholar 

  • Raisman, G., W. M. Cowan, and T. P. S. Powell: The extrinsic afferent, commissural and association fibres of the hippocampus. Brain 88, 963–996 (1965).

    Article  Google Scholar 

  • Reynolds, E. S.: The use of lead citrate at high pH as an electronopaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This study was supported in part by Grant NB 02215 from the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service.

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Nafstad, P.H.J. An electron microscope study on the termination of the perforant path fibres in the hippocampus and the fascia dentata. Zeitschrift für Zellforschung 76, 532–542 (1967). https://doi.org/10.1007/BF00339754

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